KEGG   Homo sapiens (human): 5429Help
Entry
5429              CDS       T01001                                 

Gene name
POLH, RAD30, RAD30A, XP-V, XPV
Definition
(RefSeq) DNA polymerase eta
  KO
K03509  DNA polymerase eta [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa03460  Fanconi anemia pathway
Disease
H00403  Disorders of nucleotide excision repair
H01428  Xeroderma pigmentosum
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    5429 (POLH)
 09160 Human Diseases
  09176 Drug resistance: Antineoplastic
   01524 Platinum drug resistance
    5429 (POLH)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5429 (POLH)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic Type
  TLS (translesion DNA synthesis) factors
   Y-family DNA polymerases
    5429 (POLH)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: IMS zf_UBZ IMS_C IMS_HHH PRP21_like_P
Motif
Other DBs
NCBI-GeneID: 5429
NCBI-ProteinID: NP_006493
OMIM: 603968
HGNC: 9181
Ensembl: ENSG00000170734
Vega: OTTHUMG00000014743
Pharos: Q9Y253(Tbio)
UniProt: Q9Y253 A0A024RD62
Structure
PDB: 

Position
6p21.1
AA seq 713 aa AA seqDB search
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVT
RSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVD
LTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQI
DNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSH
GSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYA
MCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDND
RVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLT
MLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSL
ESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPFQTSQSTGTEPFFKQKSLLLK
QKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPVCEGVSKLEESSKATPAEMDLAHN
SQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEHMDYHFALELQ
KSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPRPEGMQTLESFFKPLTH
NT seq 2142 nt NT seq  +upstreamnt  +downstreamnt
atggctactggacaggatcgagtggttgctctcgtggacatggactgtttttttgttcaa
gtggagcagcggcaaaatcctcatttgaggaataaaccttgtgcagttgtacagtacaaa
tcatggaagggtggtggaataattgcagtgagttatgaagctcgtgcatttggagtcact
agaagtatgtgggcagatgatgctaagaagttatgtccagatcttctactggcacaagtt
cgtgagtcccgtgggaaagctaacctcaccaagtaccgggaagccagtgttgaagtgatg
gagataatgtctcgttttgctgtgattgaacgtgccagcattgatgaggcttacgtagat
ctgaccagtgctgtacaagagagactacaaaagctacaaggtcagcctatctcggcagac
ttgttgccaagcacttacattgaagggttgccccaaggccctacaacggcagaagagact
gttcagaaagaggggatgcgaaaacaaggcttatttcaatggctcgattctcttcagatt
gataacctcacctctccagacctgcagctcaccgtgggagcagtgattgtggaggaaatg
agagcagccatagagagggagactggttttcagtgttcagctggaatttcacacaataag
gtcctggcaaaactggcctgtggactaaacaagcccaaccgccaaaccctggtttcacat
gggtcagtcccacagctcttcagccaaatgcccattcgcaaaatccgtagtcttggagga
aagctaggggcctctgtcattgagatcctagggatagaatacatgggtgaactgacccag
ttcactgaatcccagctccagagtcattttggggagaagaatgggtcttggctatatgcc
atgtgccgagggattgaacatgatccagttaaacccaggcaactacccaaaaccattggc
tgtagtaagaacttcccaggaaaaacagctcttgctactcgggaacaggtacaatggtgg
ctgttgcaattagcccaggaactagaggagagactgactaaagaccgaaatgataatgac
agggtagccacccagctggttgtgagcattcgtgtacaaggagacaaacgcctcagcagc
ctgcgccgctgctgtgcccttacccgctatgatgctcacaagatgagccatgatgcattt
actgtcatcaagaactgtaatacttctggaatccagacagaatggtctcctcctctcaca
atgcttttcctctgtgctacaaaattttctgcctctgccccttcatcttctacagacatc
accagcttcttgagcagtgacccaagttctctgccaaaggtgccagttaccagctcagaa
gctaagacccagggaagtggcccagcggtgacagccactaagaaagcaaccacgtctctg
gaatcattcttccaaaaagctgcagaaaggcagaaagttaaagaagcttcgctttcatct
cttactgctcccactcaggctcccatgagcaattcaccatccaagccctcattacctttt
caaaccagtcaaagtacaggaactgagcccttctttaagcagaaaagtctgcttctaaag
cagaaacagcttaataattcttcagtttcttccccccaacaaaacccatggtccaactgt
aaagcattaccaaactctttaccaacagagtatccagggtgtgtccctgtttgtgaaggg
gtgtcgaagctagaagaatcctctaaagcaactcctgcagagatggatttggcccacaac
agccaaagcatgcacgcctcttcagcttccaaatctgtgctggaggtgactcagaaagca
accccaaatccaagtcttctagctgctgaggaccaagtgccctgtgagaagtgtggctcc
ctggtaccggtatgggatatgccagaacacatggactatcattttgcattggagttgcag
aaatcctttttgcagccccactcttcaaacccccaggttgtttctgccgtatctcatcaa
ggcaaaagaaatcccaagagccctttggcctgcactaataaacgccccaggcctgagggc
atgcaaacattggaatcattttttaagccattaacacattag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (31)   
   RefSeq(nuc) (7)   
   GenBank (12)   
   EMBL (12)   
Protein domain (5)   
   Pfam (5)   
All databases (74)   

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