KEGG   Homo sapiens (human): 5429
Entry
5429              CDS       T01001                                 
Symbol
POLH, RAD30, RAD30A, XP-V, XPV
Name
(RefSeq) DNA polymerase eta
  KO
K03509  DNA polymerase eta [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa03460  Fanconi anemia pathway
Network
nt06502  Nucleotide excision repair
nt06506  Double-strand break repair
  Element
N01431  Core NER reaction
N01452  Homologous recombination
Disease
H00403  Disorders of nucleotide excision repair
H01428  Xeroderma pigmentosum
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    5429 (POLH)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    5429 (POLH)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5429 (POLH)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5429 (POLH)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  TLS (translesion DNA synthesis) factors
   Y-family DNA polymerases
    5429 (POLH)
SSDB
Motif
Pfam: IMS POLH-Rev1_HhH zf_UBZ IMS_HHH_1 IMS_C IMS_HHH
Other DBs
NCBI-GeneID: 5429
NCBI-ProteinID: NP_006493
OMIM: 603968
HGNC: 9181
Ensembl: ENSG00000170734
UniProt: Q9Y253
Structure
Position
6:43576185..43620523
AA seq 713 aa
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVT
RSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVD
LTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQI
DNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSH
GSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYA
MCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDND
RVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLT
MLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSL
ESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPFQTSQSTGTEPFFKQKSLLLK
QKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPVCEGVSKLEESSKATPAEMDLAHN
SQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEHMDYHFALELQ
KSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPRPEGMQTLESFFKPLTH
NT seq 2142 nt   +upstreamnt  +downstreamnt
atggctactggacaggatcgagtggttgctctcgtggacatggactgtttttttgttcaa
gtggagcagcggcaaaatcctcatttgaggaataaaccttgtgcagttgtacagtacaaa
tcatggaagggtggtggaataattgcagtgagttatgaagctcgtgcatttggagtcact
agaagtatgtgggcagatgatgctaagaagttatgtccagatcttctactggcacaagtt
cgtgagtcccgtgggaaagctaacctcaccaagtaccgggaagccagtgttgaagtgatg
gagataatgtctcgttttgctgtgattgaacgtgccagcattgatgaggcttacgtagat
ctgaccagtgctgtacaagagagactacaaaagctacaaggtcagcctatctcggcagac
ttgttgccaagcacttacattgaagggttgccccaaggccctacaacggcagaagagact
gttcagaaagaggggatgcgaaaacaaggcttatttcaatggctcgattctcttcagatt
gataacctcacctctccagacctgcagctcaccgtgggagcagtgattgtggaggaaatg
agagcagccatagagagggagactggttttcagtgttcagctggaatttcacacaataag
gtcctggcaaaactggcctgtggactaaacaagcccaaccgccaaaccctggtttcacat
gggtcagtcccacagctcttcagccaaatgcccattcgcaaaatccgtagtcttggagga
aagctaggggcctctgtcattgagatcctagggatagaatacatgggtgaactgacccag
ttcactgaatcccagctccagagtcattttggggagaagaatgggtcttggctatatgcc
atgtgccgagggattgaacatgatccagttaaacccaggcaactacccaaaaccattggc
tgtagtaagaacttcccaggaaaaacagctcttgctactcgggaacaggtacaatggtgg
ctgttgcaattagcccaggaactagaggagagactgactaaagaccgaaatgataatgac
agggtagccacccagctggttgtgagcattcgtgtacaaggagacaaacgcctcagcagc
ctgcgccgctgctgtgcccttacccgctatgatgctcacaagatgagccatgatgcattt
actgtcatcaagaactgtaatacttctggaatccagacagaatggtctcctcctctcaca
atgcttttcctctgtgctacaaaattttctgcctctgccccttcatcttctacagacatc
accagcttcttgagcagtgacccaagttctctgccaaaggtgccagttaccagctcagaa
gctaagacccagggaagtggcccagcggtgacagccactaagaaagcaaccacgtctctg
gaatcattcttccaaaaagctgcagaaaggcagaaagttaaagaagcttcgctttcatct
cttactgctcccactcaggctcccatgagcaattcaccatccaagccctcattacctttt
caaaccagtcaaagtacaggaactgagcccttctttaagcagaaaagtctgcttctaaag
cagaaacagcttaataattcttcagtttcttccccccaacaaaacccatggtccaactgt
aaagcattaccaaactctttaccaacagagtatccagggtgtgtccctgtttgtgaaggg
gtgtcgaagctagaagaatcctctaaagcaactcctgcagagatggatttggcccacaac
agccaaagcatgcacgcctcttcagcttccaaatctgtgctggaggtgactcagaaagca
accccaaatccaagtcttctagctgctgaggaccaagtgccctgtgagaagtgtggctcc
ctggtaccggtatgggatatgccagaacacatggactatcattttgcattggagttgcag
aaatcctttttgcagccccactcttcaaacccccaggttgtttctgccgtatctcatcaa
ggcaaaagaaatcccaagagccctttggcctgcactaataaacgccccaggcctgagggc
atgcaaacattggaatcattttttaagccattaacacattag

  All links  
Disease (2)   
   OMIM (2)   
Gene (13)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (31)   
   RefSeq(nuc) (5)   
   GenBank (13)   
   EMBL (13)   
3D Structure (241)   
   PDB (241)   
Protein domain (6)   
   Pfam (6)   
All databases (300)   

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