| Entry |
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| Symbol |
PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A
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| Name |
(RefSeq) protein phosphatase 1 catalytic subunit alpha
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| KO |
| K06269 | serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] |
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| Organism |
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05168 | Herpes simplex virus 1 infection |
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| Network |
nt06168 Herpes simplex virus 1 (HSV-1) nt06515 Regulation of kinetochore-microtubule interactions nt06526 MAPK signaling |
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| Element |
| N00572 | HSV ICP34.5 to PKR-eIF2alpha signaling pathway |
| N01531 | CENPE interaction with NDC80 complex |
| N01536 | Dephosphorylation of kinetochore |
| N01598 | Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
09122 Translation
03015 mRNA surveillance pathway
5499 (PPP1CA)
09130 Environmental Information Processing
09132 Signal transduction
04390 Hippo signaling pathway
5499 (PPP1CA)
04024 cAMP signaling pathway
5499 (PPP1CA)
04022 cGMP-PKG signaling pathway
5499 (PPP1CA)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
5499 (PPP1CA)
09152 Endocrine system
04921 Oxytocin signaling pathway
5499 (PPP1CA)
09156 Nervous system
04728 Dopaminergic synapse
5499 (PPP1CA)
04720 Long-term potentiation
5499 (PPP1CA)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
5499 (PPP1CA)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
5499 (PPP1CA)
09165 Substance dependence
05031 Amphetamine addiction
5499 (PPP1CA)
05034 Alcoholism
5499 (PPP1CA)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
5499 (PPP1CA)
09167 Endocrine and metabolic disease
04931 Insulin resistance
5499 (PPP1CA)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:hsa01009]
5499 (PPP1CA)
09182 Protein families: genetic information processing
03021 Transcription machinery [BR:hsa03021]
5499 (PPP1CA)
03019 Messenger RNA biogenesis [BR:hsa03019]
5499 (PPP1CA)
03041 Spliceosome [BR:hsa03041]
5499 (PPP1CA)
Enzymes [BR:hsa01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.16 protein-serine/threonine phosphatase
5499 (PPP1CA)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
Catalytic subunits
5499 (PPP1CA)
Transcription machinery [BR:hsa03021]
Eukaryotic type
RNA polymerase II system
Other transcription-related factors
Transcription termination factor
5499 (PPP1CA)
Messenger RNA biogenesis [BR:hsa03019]
Eukaryotic type
mRNA processing factors
3' end processing
Cleavage and polyadenylation specificity factor (CPSF) complex
5499 (PPP1CA)
Spliceosome [BR:hsa03041]
Other splicing related proteins
Spliceosome associated proteins (SAPs)
Other SAPs
5499 (PPP1CA)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
11:complement(67398183..67401858)
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| AA seq |
330 aa
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK |
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| NT seq |
993 nt +upstreamnt +downstreamnt
atgtccgacagcgagaagctcaacctggactcgatcatcgggcgcctgctggaagtgcag
ggctcgcggcctggcaagaatgtacagctgacagagaacgagatccgcggtctgtgcctg
aaatcccgggagatttttctgagccagcccattcttctggagctggaggcacccctcaag
atctgcggtgacatacacggccagtactacgaccttctgcgactatttgagtatggcggt
ttccctcccgagagcaactacctctttctgggggactatgtggacaggggcaagcagtcc
ttggagaccatctgcctgctgctggcctataagatcaagtaccccgagaacttcttcctg
ctccgtgggaaccacgagtgtgccagcatcaaccgcatctatggtttctacgatgagtgc
aagagacgctacaacatcaaactgtggaaaaccttcactgactgcttcaactgcctgccc
atcgcggccatagtggacgaaaagatcttctgctgccacggaggcctgtccccggacctg
cagtctatggagcagattcggcggatcatgcggcccacagatgtgcctgaccagggcctg
ctgtgtgacctgctgtggtctgaccctgacaaggacgtgcagggctggggcgagaacgac
cgtggcgtctcttttacctttggagccgaggtggtggccaagttcctccacaagcacgac
ttggacctcatctgccgagcacaccaggtggtagaagacggctacgagttctttgccaag
cggcagctggtgacacttttctcagctcccaactactgtggcgagtttgacaatgctggc
gccatgatgagtgtggacgagaccctcatgtgctctttccagatcctcaagcccgccgac
aagaacaaggggaagtacgggcagttcagtggcctgaaccctggaggccgacccatcacc
ccaccccgcaattccgccaaagccaagaaatag |
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