KEGG   Homo sapiens (human): 55294
Entry
55294             CDS       T01001                                 
Symbol
FBXW7, AGO, CDC4, DEDHIL, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
Name
(RefSeq) F-box and WD repeat domain containing 7
  KO
K10260  F-box and WD-40 domain protein 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
Disease
H02685  Developmental delay with neuropsychiatric disorders
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    55294 (FBXW7)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    55294 (FBXW7)
   04121 Ubiquitin system [BR:hsa04121]
    55294 (FBXW7)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    55294 (FBXW7)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Target recognizing subunit (F-box)
     55294 (FBXW7)
SSDB
Motif
Pfam: WD40 F-box-like ANAPC4_WD40 Nup160 NBCH_WD40 F-box PQQ_2 Ge1_WD40 WD40_like eIF2A CDtoxinA PALB2_WD40
Other DBs
NCBI-GeneID: 55294
NCBI-ProteinID: NP_361014
OMIM: 606278
HGNC: 16712
Ensembl: ENSG00000109670
UniProt: Q969H0
Structure
Position
4:complement(152320544..152536092)
AA seq 707 aa
MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVV
GVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQ
ESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRS
FSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKM
FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD
LLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHR
IDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH
TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRD
ATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGH
TNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNAD
STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL
VTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK
NT seq 2124 nt   +upstreamnt  +downstreamnt
atgaatcaggaactgctctctgtgggcagcaaaagacgacgaactggaggctctctgaga
ggtaacccttcctcaagccaggtagatgaagaacagatgaatcgtgtggtagaggaggaa
cagcaacagcaactcagacaacaagaggaggagcacactgcaaggaatggtgaagttgtt
ggagtagaacctagacctggaggccaaaatgattcccagcaaggacagttggaagaaaac
aataatagatttatttcggtagatgaggactcctcaggaaaccaagaagaacaagaggaa
gatgaagaacatgctggtgaacaagatgaggaggatgaggaggaggaggagatggaccag
gagagtgacgattttgatcagtctgatgatagtagcagagaagatgaacatacacatact
aacagtgtcacgaactccagtagtattgtggacctgcccgttcaccaactctcctcccca
ttctatacaaaaacaacaaaaatgaaaagaaagttggaccatggttctgaggtccgctct
ttttctttgggaaagaaaccatgcaaagtctcagaatatacaagtaccactgggcttgta
ccatgttcagcaacaccaacaacttttggggacctcagagcagccaatggccaagggcaa
caacgacgccgaattacatctgtccagccacctacaggcctccaggaatggctaaaaatg
tttcagagctggagtggaccagagaaattgcttgctttagatgaactcattgatagttgt
gaaccaacacaagtaaaacatatgatgcaagtgatagaaccccagtttcaacgagacttc
atttcattgctccctaaagagttggcactctatgtgctttcattcctggaacccaaagac
ctgctacaagcagctcagacatgtcgctactggagaattttggctgaagacaaccttctc
tggagagagaaatgcaaagaagaggggattgatgaaccattgcacatcaagagaagaaaa
gtaataaaaccaggtttcatacacagtccatggaaaagtgcatacatcagacagcacaga
attgatactaactggaggcgaggagaactcaaatctcctaaggtgctgaaaggacatgat
gatcatgtgatcacatgcttacagttttgtggtaaccgaatagttagtggttctgatgac
aacactttaaaagtttggtcagcagtcacaggcaaatgtctgagaacattagtgggacat
acaggtggagtatggtcatcacaaatgagagacaacatcatcattagtggatctacagat
cggacactcaaagtgtggaatgcagagactggagaatgtatacacaccttatatgggcat
acttccactgtgcgttgtatgcatcttcatgaaaaaagagttgttagcggttctcgagat
gccactcttagggtttgggatattgagacaggccagtgtttacatgttttgatgggtcat
gttgcagcagtccgctgtgttcaatatgatggcaggagggttgttagtggagcatatgat
tttatggtaaaggtgtgggatccagagactgaaacctgtctacacacgttgcaggggcat
actaatagagtctattcattacagtttgatggtatccatgtggtgagtggatctcttgat
acatcaatccgtgtttgggatgtggagacagggaattgcattcacacgttaacagggcac
cagtcgttaacaagtggaatggaactcaaagacaatattcttgtctctgggaatgcagat
tctacagttaaaatctgggatatcaaaacaggacagtgtttacaaacattgcaaggtccc
aacaagcatcagagtgctgtgacctgtttacagttcaacaagaactttgtaattaccagc
tcagatgatggaactgtaaaactatgggacttgaaaacgggtgaatttattcgaaaccta
gtcacattggagagtggggggagtgggggagttgtgtggcggatcagagcctcaaacaca
aagctggtgtgtgcagttgggagtcggaatgggactgaagaaaccaagctgctggtgctg
gactttgatgtggacatgaagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (31)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (29)   
DNA sequence (101)   
   RefSeq(nuc) (29)   
   GenBank (36)   
   EMBL (36)   
3D Structure (7)   
   PDB (7)   
Protein domain (12)   
   Pfam (12)   
All databases (175)   

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