KEGG   Homo sapiens (human): 5550
Entry
5550              CDS       T01001                                 
Symbol
PREP, PE, PEP
Name
(RefSeq) prolyl endopeptidase
  KO
K01322  prolyl oligopeptidase [EC:3.4.21.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    5550 (PREP)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5550 (PREP)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.26  prolyl oligopeptidase
     5550 (PREP)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S9: prolyl oligopeptidase family
   5550 (PREP)
SSDB
Motif
Pfam: Peptidase_S9_N Peptidase_S9 Esterase Hydrolase_4
Other DBs
NCBI-GeneID: 5550
NCBI-ProteinID: NP_002717
OMIM: 600400
HGNC: 9358
Ensembl: ENSG00000085377
Pharos: P48147(Tchem)
UniProt: P48147 B2RAH7
Structure
Position
6:complement(105273218..105403082)
AA seq 710 aa
MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
NT seq 2133 nt   +upstreamnt  +downstreamnt
atgctgtcccttcagtaccccgacgtgtaccgcgacgagaccgccgtacaggattatcat
ggtcataaaatttgtgacccttacgcctggcttgaagaccccgacagtgaacagactaag
gcctttgtggaggcccagaataagattactgtgccatttcttgagcagtgtcccatcaga
ggtttatacaaagagagaatgactgaactatatgattatcccaagtatagttgccacttc
aagaaaggaaaacggtatttttatttttacaatacaggtttgcagaaccagcgagtatta
tatgtacaggattccttagagggtgaggccagagtgttcctggaccccaacatactgtct
gacgatggcacagtggcactccgaggttatgcgttcagcgaagatggtgaatattttgcc
tatggtctgagtgccagtggctcagactgggtgacaatcaagttcatgaaagttgatggt
gccaaagagcttccagatgtgcttgaaagagtcaagttcagctgtatggcctggacccat
gatgggaagggaatgttctacaactcataccctcaacaggatggaaaaagtgatggcaca
gagacatctaccaatctccaccaaaagctctactaccatgtcttgggaaccgatcagtca
gaagatattttgtgtgctgagtttcctgatgaacctaaatggatgggtggagctgagtta
tctgatgatggccgctatgtcttgttatcaataagggaaggatgtgatccagtaaaccga
ctctggtactgtgacctacagcaggaatccagtggcatcgcgggaatcctgaagtgggta
aaactgattgacaactttgaaggggaatatgactacgtgaccaatgaggggacggtgttc
acattcaagacgaatcgccagtctcccaactatcgcgtgatcaacattgacttcagggat
cctgaagagtctaagtggaaagtacttgttcctgagcatgagaaagatgtcttagaatgg
atagcttgtgtcaggtccaacttcttggtcttatgctacctccatgacgtcaagaacatt
ctgcagctccatgacctgactactggtgctctccttaagaccttcccgctcgatgtcggc
agcattgtagggtacagcggtcagaagaaggacactgaaatcttctatcagtttacttcc
tttttatctccaggtatcatttatcactgtgatcttaccaaagaggagctggagccaaga
gttttccgagaggtgaccgtaaaaggaattgatgcttctgattaccagacagtccagatt
ttctaccctagcaaggatggtacgaagattccaatgttcattgtgcataaaaaaggcata
aaattggatggctctcatccagctttcttatatggctatggcggcttcaacatatccatc
acacccaactacagtgtttccaggcttatttttgtgagacacatgggtggtatcctggca
gtggccaacatcagaggaggtggcgaatatggagagacgtggcataaaggtggtatcttg
gccaacaaacaaaactgctttgatgactttcagtgtgctgctgagtatctgatcaaggaa
ggttacacatctcccaagaggctgactattaatggaggttcaaatggaggcctcttagtg
gctgcttgtgcaaatcagagacctgacctctttggttgtgttattgcccaagttggagta
atggacatgctgaagtttcataaatataccatcggccatgcttggaccactgattatggg
tgctcggacagcaaacaacactttgaatggcttgtcaaatactctccattgcataatgtg
aagttaccagaagcagatgacatccagtacccgtccatgctgctcctcactgctgaccat
gatgaccgcgtggtcccgcttcactccctgaagttcattgccacccttcagtacatcgtg
ggccgcagcaggaagcaaagcaaccccctgcttatccacgtggacaccaaggcgggccac
ggggcggggaagcccacagccaaagtgatagaggaagtctcagacatgtttgcgttcatc
gcgcggtgcctgaacgtcgactggattccataa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (23)   
   RefSeq(nuc) (3)   
   GenBank (10)   
   EMBL (10)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   Pfam (4)   
All databases (58)   

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