KEGG   Homo sapiens (human): 55626Help
Entry
55626             CDS       T01001                                 

Gene name
AMBRA1, DCAF3, WDR94
Definition
(RefSeq) autophagy and beclin 1 regulator 1
  KO
K17985  activating molecule in BECN1-regulated autophagy protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
Network
nt06128  Autophagy (viruses)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06228  Autophagy
  Element
N00155  Autophagy-vesicle nucleation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    55626 (AMBRA1)
   04137 Mitophagy - animal
    55626 (AMBRA1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    55626 (AMBRA1)
   05017 Spinocerebellar ataxia
    55626 (AMBRA1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    55626 (AMBRA1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    55626 (AMBRA1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    55626 (AMBRA1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    55626 (AMBRA1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: ANAPC4_WD40 WD40 Spt20 eIF2A Acyl_CoA_thio
Motif
Other DBs
NCBI-GeneID: 55626
NCBI-ProteinID: NP_001254711
OMIM: 611359
HGNC: 25990
Ensembl: ENSG00000110497
Vega: OTTHUMG00000166500
Pharos: Q9C0C7(Tbio)
UniProt: Q9C0C7
Position
11p11.2
AA seq 1301 aa AA seqDB search
MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
HNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGP
TRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSLLSV
LRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEY
DRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLNRCRA
CHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTPSSS
RLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLR
RRSLALSPRLEYSGAILAHCKLRLPGSCHSPASASQVAGTTGAHHHARLIFAFLVEMEFH
HVSQAGLELLTSGDLPTSASQSAGITGVSHRAWPRLLESSLISLSRYDGAGSREHPIYPD
PARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFE
DFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNR
VLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDI
SADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVM
VGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWL
PEPGLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWR
TDRDMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEG
SEYGASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTE
PGAAHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIP
VSLPSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
NT seq 3906 nt NT seq  +upstreamnt  +downstreamnt
atgaaggttgtcccagaaaagaatgctgtccggatactctgggggcgagaacggggtgct
cgggccatgggagctcagcggcttctgcaggagctggtagaagataaaacccggtggatg
aaatgggagggcaagagagtagaactgccggatagtccacgctctaccttcttattggcc
ttcagcccagacaggactctcttagcctccacccatgtgaaccataatatctatattacg
gaggtgaagactggcaagtgtgttcattccctgattggacaccgccgtactccatggtgt
gtcacttttcatcccaccatctcaggccttattgcttctggctgcctagatggggaggtt
aggatttgggatttacacggtggcagtgaaagctggttcacagatagcaacaatgccatt
gcctccctggctttccaccctacggctcagctcctgctgattgccactgccaatgagatc
cacttctgggactggagtcgacgggaaccctttgctgtggtgaagacagctagtgagatg
gaacgggtccgtctggtgagatttgatccacttggacactacttactcacagcaattgtt
aacccctctaatcaacagggtgatgacgaaccagagatccccatagatggaacagaatta
tcccactaccgtcagcgtgccctcctgcaatcacagccagttcgccggacgcctctcctc
cacaatttcctgcacatgctgtcctcccgctcttctggcatccagaccgagcccttccat
cccccggagcaggcctcgtcaacgcagcaggaccagggcctcctgaaccggccgtctgcc
ttcagtacagtccagagcagcactgccggcaacacgctccgcaacctcagtctgggtcct
acccgccgctctttgggagggcctctgtctagccacccttctaggtatcaccgagaaata
gctcctgggttgacaggatctgagtggacccggacagtactcagtctgaactcccgctct
gaggcggaatccatgcccccgcccagaaccagtgcctcttcggtgagtttgctgtctgtg
ctgagacagcaggaaggtggctctcaggcatctgtgtacacttcagccacagaagggagg
ggttttccggcatcagggttggcaactgagtcagatggagggaatggctccagccaaaac
aactcgggcagcattcgccatgagcttcagtgtgacctgagacgcttctttctggagtat
gaccggcttcaggagctggatcagagcctgagtggggaagctccccagacccaacaggcc
caggaaatgctcaacaataacattgaatctgagaggccaggcccttcccaccagcccacc
ccacacagcagtgagaacaactccaacctgtcccgtggccacctgaatcgctgtcgtgct
tgccacaatctcctgaccttcaacaacgataccctgcgctgggaaagaaccacacctaac
tactcctctggcgaggctagttcctcttggcaggtccccagctcctttgagagtgtgcca
tcaagtggcagccagttgccacctctcgagcggactgagggccaaacgcccagctccagc
aggctggagttgagcagctctgctagtccgcaggaggagaggactgtgggggtggccttt
aaccaggagacaggccactgggaaagaatttacacccagtccagcagatctggaactgtg
tcacaggaggccttacatcaggatatgcctgaggagagctctgaggaggattcactcagg
agacggagtcttgctctgtcacctaggctggagtacagcggcgctatcttggctcactgc
aagctccgcctcccaggttcatgccattctcctgcctcagcttcccaagtagctgggact
acgggagcccaccaccacgcccggctaatttttgcatttttagtagagatggagtttcac
catgttagccaggctggtctcgaactcctgacctcaggtgatctgcccacctcggcctcc
caaagtgctgggattacaggcgtgagccaccgcgcctggccgaggctgctggaatcttcc
ctcatttcattatcccgttatgatggagcaggatccagagagcacccaatttacccagac
ccagcgagattatctcctgctgcatactacgcccagaggatgatccagtatctctcacgg
agagacagtattcgccagcgctccatgcgctaccaacagaaccgtctccgttcttccacc
tcctcctcttcctcagacaaccagggtccatcagtagagggaaccgacttggaatttgag
gactttgaggacaatggtgacagatccaggcaccgagctccacgcaatgcccggatgtct
gcaccttcgcttggacgctttgtcccaaggcgtttcttgctgcctgagtacttgccttat
gctgggatttttcatgaacgtggacagcctggcttggctactcactcttctgttaacagg
gtcctggcaggggcagtgatcggtgatggacagtctgctgtggccagtaacattgccaat
actacctaccggctccagtggtgggacttcactaagtttgacctccctgaaatcagtaat
gcttccgtgaatgtgctggtgcagaactgcaagatctacaatgatgccagctgtgacatt
tctgcagatggccagctcctggcagctttcatccccagcagccagaggggctttcctgat
gaaggcatcctggcagtgtactccctggccccccataacctgggcgaaatgctctacacc
aagcgatttggtcccaatgccatttcggtgagcctgtccccaatgggcagatatgtaatg
gtgggcttggcctcacgaaggatcctgctgcacccctccacagagcacatggtggcccag
gtcttcaggctgcaacaggcccatggtggagagacctccatgaggagagttttcaacgtc
ctttatcccatgcctgccgaccagcggagacatgtcagtatcaactctgcccgttggctg
cctgagccagggcttggcttggcctatggtactaacaaaggagacctggtgatctgccga
ccagaggccttaaactctggtgttgagtactactgggaccagctgaacgagacggtcttc
actgtccattccaacagcaggagcagcgagcggcctggaaccagcagagccacatggagg
acagacagagacatggggctgatgaatgccattgggcttcagccccggaaccctgccacc
tcagtgacatctcagggcacccagactctggcccttcagctgcagaatgccgaaacacag
actgagagggaggtgccggagccagggacagccgcctcaggtcctggtgaaggtgagggt
tcagagtatggtgccagtggagaagatgcgctcagcaggatccagaggctgatggcggag
ggcggcatgacagccgtggtgcagcgggagcagagcaccaccatggcctccatgggcggc
ttcggcaacaacatcatcgtcagccaccgcattcaccgcagctctcagacgggcactgaa
cctggtgccgcccacacctcctcaccccagccctccacctctcggggactgctcccagag
gccgggcaactggcagagcgaggcctaagcccccggacagcttcctgggaccagcctggt
acccctgggcgggagccaacccagccaaccctgccctcttcctcccctgtccccattcct
gtttcccttcccagcgctgagggaccaaccctccactgcgagttgaccaataacaaccac
cttctggatggtggcagcagcaggggggacgctgcaggccctaggggagaaccacggaac
aggtag

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