KEGG   Homo sapiens (human): 55775
Entry
55775             CDS       T01001                                 

Gene name
TDP1
Definition
(RefSeq) tyrosyl-DNA phosphodiesterase 1
  KO
K10862  tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
Organism
hsa  Homo sapiens (human)
Disease
H01891  Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    55775 (TDP1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.-  
     55775 (TDP1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Other BER factors
     55775 (TDP1)
SSDB
Motif
Pfam: Tyr-DNA_phospho RMMBL
Other DBs
NCBI-GeneID: 55775
NCBI-ProteinID: NP_001008744
OMIM: 607198
HGNC: 18884
Ensembl: ENSG00000042088
Vega: OTTHUMG00000171016
Pharos: Q9NUW8(Tchem)
UniProt: Q9NUW8 A0A024R6L5 B3KN41
Structure
PDB: 

Position
14q32.11
AA seq 608 aa
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
NT seq 1827 nt   +upstreamnt  +downstreamnt
atgtctcaggaaggcgattatgggaggtggaccatatctagtagtgatgaaagtgaggaa
gaaaagccaaaaccagacaagccatctacctcttctcttctctgtgccaggcaaggagca
gcaaatgagcccaggtacacctgttccgaggcccagaaagctgcacacaagaggaaaata
tcacctgtgaaattcagcaatacagattcagttttacctcccaaaaggcagaaaagcggt
tcccaggaggacctcggctggtgtctgtccagcagtgatgatgagctgcaaccagaaatg
ccgcagaagcaggctgagaaagtggtgatcaaaaaggagaaagacatctctgctcccaat
gacggcactgcccaaagaactgaaaatcatggcgctcccgcctgccacaggctcaaagag
gaggaagacgagtatgagacatcaggggagggccaggacatttgggacatgctggataaa
gggaaccccttccagttttacctcactagagtctctggagttaagccaaagtataactct
ggagccctccacatcaaggatattttatctcctttatttgggacgcttgtttcttcagct
cagtttaactactgctttgacgtggactggctcgtaaaacagtatccaccagagttcagg
aagaagccaatcctgcttgtgcatggtgataagcgagaggctaaggctcacctccatgcc
caggccaagccttacgagaacatctctctctgccaggcaaagttggatattgcgtttgga
acacaccacacgaaaatgatgctgctgctctatgaagaaggcctccgggttgtcatacac
acctccaacctcatccatgctgactggcaccagaaaactcaaggaatatggttgagcccc
ttatacccacgaattgctgatggaacccacaaatctggagagtcgccaacacattttaaa
gctgatctcatcagttacttgatggcttataatgccccttctctcaaggagtggatagat
gtcattcacaagcacgatctctctgaaacaaatgtttatcttattggttcaaccccagga
cgctttcaaggaagtcaaaaagataattggggacattttagacttaagaagcttctgaaa
gaccatgcctcatccatgcctaacgcagagtcctggcctgtcgtaggtcagttttcaagc
gttggctccttgggagccgatgaatcaaagtggttatgttctgagtttaaagagagcatg
ctgacactggggaaggaaagcaagactccaggaaaaagctctgttcctctttacttgatc
tatccttctgtggaaaatgtgcggaccagtttagaaggatatcctgctgggggctctctt
ccctatagcatccagacagctgaaaaacagaattggctgcattcctattttcacaaatgg
tcagctgagacttctggccgcagcaatgccatgccacatattaagacatatatgaggcct
tctccagacttcagtaaaattgcttggttccttgtcacaagcgcaaatctgtccaaggct
gcctggggagcattggagaagaatggcacccagctgatgatccgctcctacgagctcggg
gtccttttcctcccttcagcatttggtctagacagtttcaaagtgaaacagaagttcttc
gctggcagccaggagccaatggccacctttcctgtgccatatgatttgcctccagaactg
tatggaagtaaagatcggccatggatatggaacattccttatgtcaaagcaccggatacg
catgggaacatgtgggtgccctcctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (24)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (48)   
   RefSeq(nuc) (22)   
   GenBank (13)   
   EMBL (13)   
Protein domain (2)   
   Pfam (2)   
All databases (103)   

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