KEGG   Homo sapiens (human): 55775
Entry
55775             CDS       T01001                                 
Symbol
TDP1
Name
(RefSeq) tyrosyl-DNA phosphodiesterase 1
  KO
K10862  tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
Network
nt06504  Base excision repair
  Element
N01435  Base excision and strand cleavage by NEIL glycosylase
Disease
H01891  Autosomal recessive spinocerebellar ataxias
H02573  Autosomal recessive spinocerebellar ataxias with axonal neuropathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    55775 (TDP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    55775 (TDP1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Other BER factors
     55775 (TDP1)
SSDB
Motif
Pfam: Tyr-DNA_phospho RMMBL
Other DBs
NCBI-GeneID: 55775
NCBI-ProteinID: NP_001008744
OMIM: 607198
HGNC: 18884
Ensembl: ENSG00000042088
UniProt: Q9NUW8 B3KN41
Structure
Position
14:89954968..90044764
AA seq 608 aa
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
NT seq 1827 nt   +upstreamnt  +downstreamnt
atgtctcaggaaggcgattatgggaggtggaccatatctagtagtgatgaaagtgaggaa
gaaaagccaaaaccagacaagccatctacctcttctcttctctgtgccaggcaaggagca
gcaaatgagcccaggtacacctgttccgaggcccagaaagctgcacacaagaggaaaata
tcacctgtgaaattcagcaatacagattcagttttacctcccaaaaggcagaaaagcggt
tcccaggaggacctcggctggtgtctgtccagcagtgatgatgagctgcaaccagaaatg
ccgcagaagcaggctgagaaagtggtgatcaaaaaggagaaagacatctctgctcccaat
gacggcactgcccaaagaactgaaaatcatggcgctcccgcctgccacaggctcaaagag
gaggaagacgagtatgagacatcaggggagggccaggacatttgggacatgctggataaa
gggaaccccttccagttttacctcactagagtctctggagttaagccaaagtataactct
ggagccctccacatcaaggatattttatctcctttatttgggacgcttgtttcttcagct
cagtttaactactgctttgacgtggactggctcgtaaaacagtatccaccagagttcagg
aagaagccaatcctgcttgtgcatggtgataagcgagaggctaaggctcacctccatgcc
caggccaagccttacgagaacatctctctctgccaggcaaagttggatattgcgtttgga
acacaccacacgaaaatgatgctgctgctctatgaagaaggcctccgggttgtcatacac
acctccaacctcatccatgctgactggcaccagaaaactcaaggaatatggttgagcccc
ttatacccacgaattgctgatggaacccacaaatctggagagtcgccaacacattttaaa
gctgatctcatcagttacttgatggcttataatgccccttctctcaaggagtggatagat
gtcattcacaagcacgatctctctgaaacaaatgtttatcttattggttcaaccccagga
cgctttcaaggaagtcaaaaagataattggggacattttagacttaagaagcttctgaaa
gaccatgcctcatccatgcctaacgcagagtcctggcctgtcgtaggtcagttttcaagc
gttggctccttgggagccgatgaatcaaagtggttatgttctgagtttaaagagagcatg
ctgacactggggaaggaaagcaagactccaggaaaaagctctgttcctctttacttgatc
tatccttctgtggaaaatgtgcggaccagtttagaaggatatcctgctgggggctctctt
ccctatagcatccagacagctgaaaaacagaattggctgcattcctattttcacaaatgg
tcagctgagacttctggccgcagcaatgccatgccacatattaagacatatatgaggcct
tctccagacttcagtaaaattgcttggttccttgtcacaagcgcaaatctgtccaaggct
gcctggggagcattggagaagaatggcacccagctgatgatccgctcctacgagctcggg
gtccttttcctcccttcagcatttggtctagacagtttcaaagtgaaacagaagttcttc
gctggcagccaggagccaatggccacctttcctgtgccatatgatttgcctccagaactg
tatggaagtaaagatcggccatggatatggaacattccttatgtcaaagcaccggatacg
catgggaacatgtgggtgccctcctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (19)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (32)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (29)   
DNA sequence (60)   
   RefSeq(nuc) (34)   
   GenBank (13)   
   EMBL (13)   
3D Structure (48)   
   PDB (48)   
Protein domain (2)   
   Pfam (2)   
All databases (163)   

Download RDF
DBGET integrated database retrieval system