KEGG   Homo sapiens (human): 5586
Entry
5586              CDS       T01001                                 

Gene name
PKN2, PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7
Definition
(RefSeq) protein kinase N2
  KO
K23691  serine/threonine-protein kinase N2 [EC:2.7.11.13]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa05135  Yersinia infection
Network
nt06139  NLR signaling (viruses and bacteria)
  Element
N00866  Yersinia YopM to Pyrin Inflammasome signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    5586 (PKN2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    5586 (PKN2)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    5586 (PKN2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5586 (PKN2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     5586 (PKN2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  PKN family
   5586 (PKN2)
SSDB
Motif
Pfam: Pkinase HR1 PK_Tyr_Ser-Thr Pkinase_C Kinase-like Uds1 C2
Other DBs
NCBI-GeneID: 5586
NCBI-ProteinID: NP_006247
OMIM: 602549
HGNC: 9406
Ensembl: ENSG00000065243
Vega: OTTHUMG00000010074
Pharos: Q16513(Tchem)
UniProt: Q16513
Structure
PDB: 
4CRS

Position
1p22.2
AA seq 984 aa
MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL
KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR
TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL
QDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM
KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA
ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS
PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK
FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV
PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG
QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC
AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL
VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY
RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW
WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL
GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP
REPRILSEEEQEMFRDFDYIADWC
NT seq 2955 nt   +upstreamnt  +downstreamnt
atggcgtccaaccccgaacggggggagattctgctcacggaactgcagggggattcccga
agtcttccgttttctgagaatgtgagtgctgttcaaaaattagacttttcagatacaatg
gtgcagcagaaattggatgatatcaaggatcgaattaagagagaaataaggaaagaactg
aaaatcaaagaaggagctgaaaatctgaggaaagtcacaacagataaaaaaagtttggct
tatgtagacaacattttgaaaaaatcaaataaaaaattagaagaactacatcacaagctg
caggaattaaatgcacatattgttgtatcagatccagaagatattacagattgcccaagg
actccagatactccaaataatgaccctcgttgttctactagcaacaatagattgaaggcc
ttacaaaaacaattggatatagaacttaaagtaaaacaaggtgcagagaatatgatacag
atgtattcaaatggatcttcaaaggatcggaaactccatggtacagctcagcaactgctc
caggacagcaagacaaaaatagaagtcatacgaatgcagattcttcaggcagtccagact
aatgaattggcttttgataatgcaaaacctgtgataagtcctcttgaacttcggatggaa
gaattaaggcatcattttaggatagagtttgcagtagcagaaggtgcaaagaatgtaatg
aaattacttggctcaggaaaagtaacagacagaaaagcactttcagaagctcaagcaaga
tttaatgaatcaagtcagaagttggaccttttaaagtattcattagagcaaagattaaac
gaagtccccaagaatcatcccaaaagcaggattattattgaagaactttcacttgttgct
gcatcaccaacactaagtccacgtcaaagtatgatatctacgcaaaatcaatatagtaca
ctatccaaaccagcagcactaacaggtactttggaagttcgtcttatgggctgccaagat
atcctagagaatgtccctggacggtcaaaagcaacatcagttgcactgcctggttggagt
ccaagtgaaaccagatcatctttcatgagcagaacgagtaaaagtaaaagcggaagtagt
cgaaatcttctaaaaaccgatgacttgtccaatgatgtctgtgctgttttgaagctcgat
aatactgtggttggccaaactagctggaaacccatttccaatcagtcatgggaccagaag
tttacactggaactggacaggtcacgtgaactggaaatttcagtttattggcgtgattgg
cggtctctgtgtgctgtaaaatttctgaggttagaagattttttagacaaccaacggcat
ggcatgtgtctctatttggaaccacagggtactttatttgcagaggttaccttttttaat
ccagttattgaaagaagaccaaaacttcaaagacaaaagaaaattttttcaaagcaacaa
ggcaaaacatttctcagagctcctcaaatgaatattaatattgccacttggggaaggcta
gtaagaagagctattcctacagtaaatcattctggcaccttcagccctcaagctcctgtg
cctactacagtgccagtggttgatgtacgcatccctcaactagcacctccagctagtgat
tctacagtaaccaaattggactttgatcttgagcctgaacctcctccagccccaccacga
gcttcttctcttggagaaatagatgaatcttctgaattaagagttttggatataccagga
caggattcagagactgtttttgatattcagaatgacagaaatagtatacttccaaaatct
caatctgaatacaagcctgatactcctcagtcaggcctagaatatagtggtattcaagaa
cttgaggacagaagatctcagcaaaggtttcagtttaatctacaagatttcaggtgttgt
gctgtcttgggaagaggacattttggaaaggtgcttttagctgaatataaaaacacaaat
gagatgtttgctataaaagccttaaagaaaggagatattgtggctcgagatgaagtagac
agcctgatgtgtgaaaaaagaatttttgaaactgtgaatagtgtaaggcatccctttttg
gtgaacctttttgcatgtttccaaaccaaagagcatgtttgctttgtaatggaatatgct
gccggtggggacctaatgatgcacattcatactgatgtcttttctgaaccaagagctgta
ttttatgctgcttgtgtagttcttgggttgcagtatttacatgaacacaaaattgtttat
agagatttgaaattggataacttattgctagatacagagggctttgtgaaaattgctgat
tttggtctttgcaaagaaggaatgggatatggagatagaacaagcacattttgtggcact
cctgaatttcttgccccagaagtattaacagaaacttcttatacaagggctgtagattgg
tggggccttggcgtgcttatatatgaaatgcttgttggtgagtctccctttcctggtgat
gatgaagaggaagtttttgacagtattgtaaatgatgaagtaaggtatccaaggttctta
tctacagaagccatttctataatgagaaggctgttaagaagaaatcctgaacggcgcctt
ggggctagcgagaaagatgcagaggatgtaaaaaagcacccatttttccggctaattgat
tggagcgctctgatggacaaaaaagtaaagccaccatttatacctaccataagaggacga
gaagatgttagtaattttgatgatgaatttacctcagaagcacctattctgactccacct
cgagaaccaaggatactttcggaagaggagcaggaaatgttcagagattttgactacatt
gctgattggtgttaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (1)   
   KEGG NETWORK (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (35)   
   RefSeq(nuc) (7)   
   GenBank (14)   
   EMBL (14)   
Protein domain (7)   
   Pfam (7)   
All databases (82)   

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