KEGG   Homo sapiens (human): 55869
Entry
55869             CDS       T01001                                 
Symbol
HDAC8, CDA07, CDLS5, HD8, HDACL1, KDAC8, MRXS6, RPD3, WTS
Name
(RefSeq) histone deacetylase 8
  KO
K11405  histone deacetylase 8 [EC:3.5.1.98]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04613  Neutrophil extracellular trap formation
hsa05034  Alcoholism
hsa05203  Viral carcinogenesis
Network
nt06512  Chromosome cohesion and segregation
  Element
N01483  Cohesin acetylation
Disease
H00631  Cornelia de Lange syndrome
Drug target
Abexinostat (DG01402): D10060 D10084
Belinostat: D08870<US>
Bocodepsin (DG03260): D12551 D12552
Entinostat: D09338
Fimepinostat: D11319
Givinostat (DG03284): D12742 D12743<US>
Mocetinostat (DG01404): D09357 D09641
Nanatinostat: D11442
Panobinostat (DG01403): D10019 D10319
Quisinostat (DG01407): D10321 D10322
Remetinostat: D10977
Resminostat: D13021
Romidepsin: D06637<JP/US>
Vorinostat: D06320<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    55869 (HDAC8)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    55869 (HDAC8)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    55869 (HDAC8)
  09165 Substance dependence
   05034 Alcoholism
    55869 (HDAC8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    55869 (HDAC8)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.98  histone deacetylase
     55869 (HDAC8)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    Class I HDACs
     55869 (HDAC8)
SSDB
Motif
Pfam: Hist_deacetyl BFN_dom
Other DBs
NCBI-GeneID: 55869
NCBI-ProteinID: NP_060956
OMIM: 300269
HGNC: 13315
Ensembl: ENSG00000147099
UniProt: Q9BY41
Structure
Position
X:complement(72329516..72572843)
AA seq 377 aa
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
NT seq 1134 nt   +upstreamnt  +downstreamnt
atggaggagccggaggaaccggcggacagtgggcagtcgctggtcccggtttatatctat
agtcccgagtatgtcagtatgtgtgactccctggccaagatccccaaacgggccagtatg
gtgcattctttgattgaagcatatgcactgcataagcagatgaggatagttaagcctaaa
gtggcctccatggaggagatggccaccttccacactgatgcttatctgcagcatctccag
aaggtcagccaagagggcgatgatgatcatccggactccatagaatatgggctaggttat
gactgcccagccactgaagggatatttgactatgcagcagctataggaggggctacgatc
acagctgcccaatgcctgattgacggaatgtgcaaagtagcaattaactggtctggaggg
tggcatcatgcaaagaaagatgaagcatctggtttttgttatctcaatgatgctgtcctg
ggaatattacgattgcgacggaaatttgagcgtattctctacgtggatttggatctgcac
catggagatggtgtagaagacgcattcagtttcacctccaaagtcatgaccgtgtccctg
cacaaattctccccaggatttttcccaggaacaggtgacgtgtctgatgttggcctaggg
aagggacggtactacagtgtaaatgtgcccattcaggatggcatacaagatgaaaaatat
taccagatctgtgaaagtgtactaaaggaagtataccaagcctttaatcccaaagcagtg
gtcttacagctgggagctgacacaatagctggggatcccatgtgctcctttaacatgact
ccagtgggaattggcaagtgtcttaagtacatccttcaatggcagttggcaacactcatt
ttgggaggaggaggctataaccttgccaacacggctcgatgctggacatacttgaccggg
gtcatcctagggaaaacactatcctctgagatcccagatcatgagtttttcacagcatat
ggtcctgattatgtgctggaaatcacgccaagctgccggccagaccgcaatgagccccac
cgaatccaacaaatcctcaactacatcaaagggaatctgaagcatgtggtctag

  All links  
Disease (2)   
   OMIM (2)   
Gene (14)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (30)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (28)   
DNA sequence (73)   
   RefSeq(nuc) (35)   
   GenBank (19)   
   EMBL (19)   
3D Structure (53)   
   PDB (53)   
Protein domain (2)   
   Pfam (2)   
All databases (174)   

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