KEGG   Homo sapiens (human): 5588
Entry
5588              CDS       T01001                                 

Gene name
PRKCQ, PRKCT, nPKC-theta
Definition
(RefSeq) protein kinase C theta
  KO
K18052  novel protein kinase C theta type [EC:2.7.11.13]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04140  Autophagy - animal
hsa04270  Vascular smooth muscle contraction
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04920  Adipocytokine signaling pathway
hsa04931  Insulin resistance
hsa05131  Shigellosis
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00408  Type 1 diabetes mellitus
Drug target
Sotrastaurin (DG01406): D09671 D09718
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    5588 (PRKCQ)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5588 (PRKCQ)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    5588 (PRKCQ)
   04658 Th1 and Th2 cell differentiation
    5588 (PRKCQ)
   04659 Th17 cell differentiation
    5588 (PRKCQ)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    5588 (PRKCQ)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    5588 (PRKCQ)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5588 (PRKCQ)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5588 (PRKCQ)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    5588 (PRKCQ)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    5588 (PRKCQ)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5588 (PRKCQ)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     5588 (PRKCQ)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   5588 (PRKCQ)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr C1_1 Pkinase_C ABC1 zf-RING_9 Kinase-like Zf_RING C1_2 zf-RING-like Pkinase_fungal APH Haspin_kinase
Other DBs
NCBI-GeneID: 5588
NCBI-ProteinID: NP_001310194
OMIM: 600448
HGNC: 9410
Ensembl: ENSG00000065675
Vega: OTTHUMG00000017623
Pharos: Q04759(Tchem)
UniProt: Q04759
Structure
PDB: 

Position
10p15.1
AA seq 706 aa
MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
NT seq 2121 nt   +upstreamnt  +downstreamnt
atgtcgccatttcttcggattggcttgtccaactttgactgcgggtcctgccagtcttgt
cagggcgaggctgttaacccttactgtgctgtgctcgtcaaagagtatgtcgaatcagag
aacgggcagatgtatatccagaaaaagcctaccatgtacccaccctgggacagcactttt
gatgcccatatcaacaagggaagagtcatgcagatcattgtgaaaggcaaaaacgtggac
ctcatctctgaaaccaccgtggagctctactcgctggctgagaggtgcaggaagaacaac
gggaagacagaaatatggttagagctgaaacctcaaggccgaatgctaatgaatgcaaga
tactttctggaaatgagtgacacaaaggacatgaatgaatttgagacggaaggcttcttt
gctttgcatcagcgccggggtgccatcaagcaggcaaaggtccaccacgtcaagtgccac
gagttcactgccaccttcttcccacagcccacattttgctctgtctgccacgagtttgtc
tggggcctgaacaaacagggctaccagtgccgacaatgcaatgcagcaattcacaagaag
tgtattgataaagttatagcaaagtgcacaggatcagctatcaatagccgagaaaccatg
ttccacaaggagagattcaaaattgacatgccacacagatttaaagtctacaattacaag
agcccgaccttctgtgaacactgtgggaccctgctgtggggactggcacggcaaggactc
aagtgtgatgcatgtggcatgaatgtgcatcatagatgccagacaaaggtggccaacctt
tgtggcataaaccagaagctaatggctgaagcgctggccatgattgagagcactcaacag
gctcgctgcttaagagatactgaacagatcttcagagaaggtccggttgaaattggtctc
ccatgctccatcaaaaatgaagcaaggccgccatgtttaccgacaccgggaaaaagagag
cctcagggcatttcctgggagtctccgttggatgaggtggataaaatgtgccatcttcca
gaacctgaactgaacaaagaaagaccatctctgcagattaaactaaaaattgaggatttt
atcttgcacaaaatgttggggaaaggaagttttggcaaggtcttcctggcagaattcaag
aaaaccaatcaatttttcgcaataaaggccttaaagaaagatgtggtcttgatggacgat
gatgttgagtgcacgatggtagagaagagagttctttccttggcctgggagcatccgttt
ctgacgcacatgttttgtacattccagaccaaggaaaacctcttttttgtgatggagtac
ctcaacggaggggacttaatgtaccacatccaaagctgccacaagttcgacctttccaga
gcgacgttttatgctgctgaaatcattcttggtctgcagttccttcattccaaaggaata
gtctacagggacctgaagctagataacatcctgttagacaaagatggacatatcaagatc
gcggattttggaatgtgcaaggagaacatgttaggagatgccaagacgaataccttctgt
gggacacctgactacatcgccccagagatcttgctgggtcagaaatacaaccactctgtg
gactggtggtccttcggggttctcctttatgaaatgctgattggtcagtcgcctttccac
gggcaggatgaggaggagctcttccactccatccgcatggacaatcccttttacccacgg
tggctggagaaggaagcaaaggaccttctggtgaagctcttcgtgcgagaacctgagaag
aggctgggcgtgaggggagacatccgccagcaccctttgtttcgggagatcaactgggag
gaacttgaacggaaggagattgacccaccgttccggccgaaagtgaaatcaccatttgac
tgcagcaatttcgacaaagaattcttaaacgagaagccccggctgtcatttgccgacaga
gcactgatcaacagcatggaccagaatatgttcaggaacttttccttcatgaaccccggg
atggagcggctgatatcctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (11)   
   KEGG PATHWAY (11)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (41)   
   RefSeq(nuc) (11)   
   GenBank (15)   
   EMBL (15)   
Protein domain (13)   
   Pfam (13)   
All databases (105)   

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