KEGG   Homo sapiens (human): 5594Help
Entry
5594              CDS       T01001                                 

Gene name
MAPK1, ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK
Definition
(RefSeq) mitogen-activated protein kinase 1
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04114  Oocyte meiosis
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04350  TGF-beta signaling pathway
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa04540  Gap junction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04930  Type II diabetes mellitus
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04934  Cushing syndrome
hsa04960  Aldosterone-regulated sodium reabsorption
hsa05010  Alzheimer disease
hsa05020  Prion diseases
hsa05034  Alcoholism
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05140  Leishmaniasis
hsa05142  Chagas disease (American trypanosomiasis)
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
Module
hsa_M00687  MAPK (ERK1/2) signaling
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00013  Mutation-activated BRAF to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to RAS-ERK signaling pathway
N00078  Mutation-activated HRAS to RAS-ERK signaling pathway
N00152  CXCR-GNB/G-ERK signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00267  HBV HBx to host-cell-protein activation
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00318  EGFR-ERK-ACTH signaling pathway
N00319  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
Drug target
Ulixertinib: D11038
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    5594 (MAPK1)
   04015 Rap1 signaling pathway
    5594 (MAPK1)
   04010 MAPK signaling pathway
    5594 (MAPK1)
   04012 ErbB signaling pathway
    5594 (MAPK1)
   04350 TGF-beta signaling pathway
    5594 (MAPK1)
   04370 VEGF signaling pathway
    5594 (MAPK1)
   04371 Apelin signaling pathway
    5594 (MAPK1)
   04668 TNF signaling pathway
    5594 (MAPK1)
   04066 HIF-1 signaling pathway
    5594 (MAPK1)
   04068 FoxO signaling pathway
    5594 (MAPK1)
   04072 Phospholipase D signaling pathway
    5594 (MAPK1)
   04071 Sphingolipid signaling pathway
    5594 (MAPK1)
   04024 cAMP signaling pathway
    5594 (MAPK1)
   04022 cGMP - PKG signaling pathway
    5594 (MAPK1)
   04151 PI3K-Akt signaling pathway
    5594 (MAPK1)
   04150 mTOR signaling pathway
    5594 (MAPK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5594 (MAPK1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    5594 (MAPK1)
   04210 Apoptosis
    5594 (MAPK1)
   04218 Cellular senescence
    5594 (MAPK1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5594 (MAPK1)
   04520 Adherens junction
    5594 (MAPK1)
   04540 Gap junction
    5594 (MAPK1)
   04550 Signaling pathways regulating pluripotency of stem cells
    5594 (MAPK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5594 (MAPK1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5594 (MAPK1)
   04620 Toll-like receptor signaling pathway
    5594 (MAPK1)
   04621 NOD-like receptor signaling pathway
    5594 (MAPK1)
   04625 C-type lectin receptor signaling pathway
    5594 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    5594 (MAPK1)
   04660 T cell receptor signaling pathway
    5594 (MAPK1)
   04658 Th1 and Th2 cell differentiation
    5594 (MAPK1)
   04659 Th17 cell differentiation
    5594 (MAPK1)
   04657 IL-17 signaling pathway
    5594 (MAPK1)
   04662 B cell receptor signaling pathway
    5594 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    5594 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    5594 (MAPK1)
   04062 Chemokine signaling pathway
    5594 (MAPK1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5594 (MAPK1)
   04912 GnRH signaling pathway
    5594 (MAPK1)
   04915 Estrogen signaling pathway
    5594 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    5594 (MAPK1)
   04917 Prolactin signaling pathway
    5594 (MAPK1)
   04921 Oxytocin signaling pathway
    5594 (MAPK1)
   04926 Relaxin signaling pathway
    5594 (MAPK1)
   04919 Thyroid hormone signaling pathway
    5594 (MAPK1)
   04928 Parathyroid hormone synthesis, secretion and action
    5594 (MAPK1)
   04916 Melanogenesis
    5594 (MAPK1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5594 (MAPK1)
   04270 Vascular smooth muscle contraction
    5594 (MAPK1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5594 (MAPK1)
  09156 Nervous system
   04724 Glutamatergic synapse
    5594 (MAPK1)
   04725 Cholinergic synapse
    5594 (MAPK1)
   04726 Serotonergic synapse
    5594 (MAPK1)
   04720 Long-term potentiation
    5594 (MAPK1)
   04730 Long-term depression
    5594 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    5594 (MAPK1)
   04722 Neurotrophin signaling pathway
    5594 (MAPK1)
  09158 Development
   04360 Axon guidance
    5594 (MAPK1)
   04380 Osteoclast differentiation
    5594 (MAPK1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    5594 (MAPK1)
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    5594 (MAPK1)
   05230 Central carbon metabolism in cancer
    5594 (MAPK1)
   05231 Choline metabolism in cancer
    5594 (MAPK1)
   05206 MicroRNAs in cancer
    5594 (MAPK1)
   05205 Proteoglycans in cancer
    5594 (MAPK1)
   05203 Viral carcinogenesis
    5594 (MAPK1)
   05210 Colorectal cancer
    5594 (MAPK1)
   05212 Pancreatic cancer
    5594 (MAPK1)
   05225 Hepatocellular carcinoma
    5594 (MAPK1)
   05226 Gastric cancer
    5594 (MAPK1)
   05214 Glioma
    5594 (MAPK1)
   05216 Thyroid cancer
    5594 (MAPK1)
   05221 Acute myeloid leukemia
    5594 (MAPK1)
   05220 Chronic myeloid leukemia
    5594 (MAPK1)
   05218 Melanoma
    5594 (MAPK1)
   05211 Renal cell carcinoma
    5594 (MAPK1)
   05219 Bladder cancer
    5594 (MAPK1)
   05215 Prostate cancer
    5594 (MAPK1)
   05213 Endometrial cancer
    5594 (MAPK1)
   05224 Breast cancer
    5594 (MAPK1)
   05223 Non-small cell lung cancer
    5594 (MAPK1)
  09163 Neurodegenerative diseases
   05010 Alzheimer disease
    5594 (MAPK1)
   05020 Prion diseases
    5594 (MAPK1)
  09164 Substance dependence
   05034 Alcoholism
    5594 (MAPK1)
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    5594 (MAPK1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5594 (MAPK1)
   04934 Cushing syndrome
    5594 (MAPK1)
  09167 Infectious diseases
   05132 Salmonella infection
    5594 (MAPK1)
   05131 Shigellosis
    5594 (MAPK1)
   05133 Pertussis
    5594 (MAPK1)
   05152 Tuberculosis
    5594 (MAPK1)
   05164 Influenza A
    5594 (MAPK1)
   05161 Hepatitis B
    5594 (MAPK1)
   05160 Hepatitis C
    5594 (MAPK1)
   05163 Human cytomegalovirus infection
    5594 (MAPK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5594 (MAPK1)
   05165 Human papillomavirus infection
    5594 (MAPK1)
   05145 Toxoplasmosis
    5594 (MAPK1)
   05140 Leishmaniasis
    5594 (MAPK1)
   05142 Chagas disease (American trypanosomiasis)
    5594 (MAPK1)
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    5594 (MAPK1)
   01524 Platinum drug resistance
    5594 (MAPK1)
   01522 Endocrine resistance
    5594 (MAPK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5594 (MAPK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    5594 (MAPK1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5594 (MAPK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     5594 (MAPK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   5594 (MAPK1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     5594 (MAPK1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   5594 (MAPK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr APH Haspin_kinase FTA2 Choline_kinase Kinase-like Kdo
Motif
Other DBs
NCBI-GeneID: 5594
NCBI-ProteinID: NP_002736
OMIM: 176948
HGNC: 6871
Ensembl: ENSG00000100030
Vega: OTTHUMG00000030508
Pharos: P28482(Tchem)
UniProt: P28482 Q1HBJ4 Q499G7
Structure
PDB: 

Position
22q11.22
AA seq 360 aa AA seqDB search
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1083 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgac
gtggggccgcgctacaccaacctctcgtacatcggcgagggcgcctacggcatggtgtgc
tctgcttatgataatgtcaacaaagttcgagtagctatcaagaaaatcagcccctttgag
caccagacctactgccagagaaccctgagggagataaaaatcttactgcgcttcagacat
gagaacatcattggaatcaatgacattattcgagcaccaaccatcgagcaaatgaaagat
gtatatatagtacaggacctcatggaaacagatctttacaagctcttgaagacacaacac
ctcagcaatgaccatatctgctattttctctaccagatcctcagagggttaaaatatatc
cattcagctaacgttctgcaccgtgacctcaagccttccaacctgctgctcaacaccacc
tgtgatctcaagatctgtgactttggcctggcccgtgttgcagatccagaccatgatcac
acagggttcctgacagaatatgtggccacacgttggtacagggctccagaaattatgttg
aattccaagggctacaccaagtccattgatatttggtctgtaggctgcattctggcagaa
atgctttctaacaggcccatctttccagggaagcattatcttgaccagctgaaccacatt
ttgggtattcttggatccccatcacaagaagacctgaattgtataataaatttaaaagct
aggaactatttgctttctcttccacacaaaaataaggtgccatggaacaggctgttccca
aatgctgactccaaagctctggacttattggacaaaatgttgacattcaacccacacaag
aggattgaagtagaacaggctctggcccacccatatctggagcagtattacgacccgagt
gacgagcccatcgccgaagcaccattcaagttcgacatggaattggatgacttgcctaag
gaaaagctcaaagaactaatttttgaagagactgctagattccagccaggatacagatct
taa

KEGG   Homo sapiens (human): 5595Help
Entry
5595              CDS       T01001                                 

Gene name
MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK
Definition
(RefSeq) mitogen-activated protein kinase 3
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04114  Oocyte meiosis
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04350  TGF-beta signaling pathway
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa04540  Gap junction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04930  Type II diabetes mellitus
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04934  Cushing syndrome
hsa04960  Aldosterone-regulated sodium reabsorption
hsa05010  Alzheimer disease
hsa05020  Prion diseases
hsa05034  Alcoholism
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05140  Leishmaniasis
hsa05142  Chagas disease (American trypanosomiasis)
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
Module
hsa_M00687  MAPK (ERK1/2) signaling
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00013  Mutation-activated BRAF to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to RAS-ERK signaling pathway
N00078  Mutation-activated HRAS to RAS-ERK signaling pathway
N00152  CXCR-GNB/G-ERK signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00267  HBV HBx to host-cell-protein activation
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00318  EGFR-ERK-ACTH signaling pathway
N00319  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
Drug target
Ulixertinib: D11038
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    5595 (MAPK3)
   04015 Rap1 signaling pathway
    5595 (MAPK3)
   04010 MAPK signaling pathway
    5595 (MAPK3)
   04012 ErbB signaling pathway
    5595 (MAPK3)
   04350 TGF-beta signaling pathway
    5595 (MAPK3)
   04370 VEGF signaling pathway
    5595 (MAPK3)
   04371 Apelin signaling pathway
    5595 (MAPK3)
   04668 TNF signaling pathway
    5595 (MAPK3)
   04066 HIF-1 signaling pathway
    5595 (MAPK3)
   04068 FoxO signaling pathway
    5595 (MAPK3)
   04072 Phospholipase D signaling pathway
    5595 (MAPK3)
   04071 Sphingolipid signaling pathway
    5595 (MAPK3)
   04024 cAMP signaling pathway
    5595 (MAPK3)
   04022 cGMP - PKG signaling pathway
    5595 (MAPK3)
   04151 PI3K-Akt signaling pathway
    5595 (MAPK3)
   04150 mTOR signaling pathway
    5595 (MAPK3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5595 (MAPK3)
  09143 Cell growth and death
   04114 Oocyte meiosis
    5595 (MAPK3)
   04210 Apoptosis
    5595 (MAPK3)
   04218 Cellular senescence
    5595 (MAPK3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5595 (MAPK3)
   04520 Adherens junction
    5595 (MAPK3)
   04540 Gap junction
    5595 (MAPK3)
   04550 Signaling pathways regulating pluripotency of stem cells
    5595 (MAPK3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5595 (MAPK3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5595 (MAPK3)
   04620 Toll-like receptor signaling pathway
    5595 (MAPK3)
   04621 NOD-like receptor signaling pathway
    5595 (MAPK3)
   04625 C-type lectin receptor signaling pathway
    5595 (MAPK3)
   04650 Natural killer cell mediated cytotoxicity
    5595 (MAPK3)
   04660 T cell receptor signaling pathway
    5595 (MAPK3)
   04658 Th1 and Th2 cell differentiation
    5595 (MAPK3)
   04659 Th17 cell differentiation
    5595 (MAPK3)
   04657 IL-17 signaling pathway
    5595 (MAPK3)
   04662 B cell receptor signaling pathway
    5595 (MAPK3)
   04664 Fc epsilon RI signaling pathway
    5595 (MAPK3)
   04666 Fc gamma R-mediated phagocytosis
    5595 (MAPK3)
   04062 Chemokine signaling pathway
    5595 (MAPK3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5595 (MAPK3)
   04912 GnRH signaling pathway
    5595 (MAPK3)
   04915 Estrogen signaling pathway
    5595 (MAPK3)
   04914 Progesterone-mediated oocyte maturation
    5595 (MAPK3)
   04917 Prolactin signaling pathway
    5595 (MAPK3)
   04921 Oxytocin signaling pathway
    5595 (MAPK3)
   04926 Relaxin signaling pathway
    5595 (MAPK3)
   04919 Thyroid hormone signaling pathway
    5595 (MAPK3)
   04928 Parathyroid hormone synthesis, secretion and action
    5595 (MAPK3)
   04916 Melanogenesis
    5595 (MAPK3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5595 (MAPK3)
   04270 Vascular smooth muscle contraction
    5595 (MAPK3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5595 (MAPK3)
  09156 Nervous system
   04724 Glutamatergic synapse
    5595 (MAPK3)
   04725 Cholinergic synapse
    5595 (MAPK3)
   04726 Serotonergic synapse
    5595 (MAPK3)
   04720 Long-term potentiation
    5595 (MAPK3)
   04730 Long-term depression
    5595 (MAPK3)
   04723 Retrograde endocannabinoid signaling
    5595 (MAPK3)
   04722 Neurotrophin signaling pathway
    5595 (MAPK3)
  09158 Development
   04360 Axon guidance
    5595 (MAPK3)
   04380 Osteoclast differentiation
    5595 (MAPK3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    5595 (MAPK3)
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    5595 (MAPK3)
   05230 Central carbon metabolism in cancer
    5595 (MAPK3)
   05231 Choline metabolism in cancer
    5595 (MAPK3)
   05205 Proteoglycans in cancer
    5595 (MAPK3)
   05203 Viral carcinogenesis
    5595 (MAPK3)
   05210 Colorectal cancer
    5595 (MAPK3)
   05212 Pancreatic cancer
    5595 (MAPK3)
   05225 Hepatocellular carcinoma
    5595 (MAPK3)
   05226 Gastric cancer
    5595 (MAPK3)
   05214 Glioma
    5595 (MAPK3)
   05216 Thyroid cancer
    5595 (MAPK3)
   05221 Acute myeloid leukemia
    5595 (MAPK3)
   05220 Chronic myeloid leukemia
    5595 (MAPK3)
   05218 Melanoma
    5595 (MAPK3)
   05211 Renal cell carcinoma
    5595 (MAPK3)
   05219 Bladder cancer
    5595 (MAPK3)
   05215 Prostate cancer
    5595 (MAPK3)
   05213 Endometrial cancer
    5595 (MAPK3)
   05224 Breast cancer
    5595 (MAPK3)
   05223 Non-small cell lung cancer
    5595 (MAPK3)
  09163 Neurodegenerative diseases
   05010 Alzheimer disease
    5595 (MAPK3)
   05020 Prion diseases
    5595 (MAPK3)
  09164 Substance dependence
   05034 Alcoholism
    5595 (MAPK3)
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    5595 (MAPK3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5595 (MAPK3)
   04934 Cushing syndrome
    5595 (MAPK3)
  09167 Infectious diseases
   05132 Salmonella infection
    5595 (MAPK3)
   05131 Shigellosis
    5595 (MAPK3)
   05133 Pertussis
    5595 (MAPK3)
   05152 Tuberculosis
    5595 (MAPK3)
   05164 Influenza A
    5595 (MAPK3)
   05161 Hepatitis B
    5595 (MAPK3)
   05160 Hepatitis C
    5595 (MAPK3)
   05163 Human cytomegalovirus infection
    5595 (MAPK3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5595 (MAPK3)
   05165 Human papillomavirus infection
    5595 (MAPK3)
   05145 Toxoplasmosis
    5595 (MAPK3)
   05140 Leishmaniasis
    5595 (MAPK3)
   05142 Chagas disease (American trypanosomiasis)
    5595 (MAPK3)
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    5595 (MAPK3)
   01524 Platinum drug resistance
    5595 (MAPK3)
   01522 Endocrine resistance
    5595 (MAPK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5595 (MAPK3)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    5595 (MAPK3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5595 (MAPK3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     5595 (MAPK3)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   5595 (MAPK3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     5595 (MAPK3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   5595 (MAPK3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr APH Haspin_kinase Kdo FTA2 Choline_kinase
Motif
Other DBs
NCBI-GeneID: 5595
NCBI-ProteinID: NP_002737
OMIM: 601795
HGNC: 6877
Ensembl: ENSG00000102882
Vega: OTTHUMG00000132149
Pharos: P27361(Tchem)
UniProt: P27361 L7RXH5
Structure
PDB: 

Position
16p11.2
AA seq 379 aa AA seqDB search
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
NT seq 1140 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggctcaggggggcgggggcggggagccccgtagaaccgagggggtc
ggcccgggggtcccgggggaggtggagatggtgaaggggcagccgttcgacgtgggcccg
cgctacacgcagttgcagtacatcggcgagggcgcgtacggcatggtcagctcggcctat
gaccacgtgcgcaagactcgcgtggccatcaagaagatcagccccttcgaacatcagacc
tactgccagcgcacgctccgggagatccagatcctgctgcgcttccgccatgagaatgtc
atcggcatccgagacattctgcgggcgtccaccctggaagccatgagagatgtctacatt
gtgcaggacctgatggagactgacctgtacaagttgctgaaaagccagcagctgagcaat
gaccatatctgctacttcctctaccagatcctgcggggcctcaagtacatccactccgcc
aacgtgctccaccgagatctaaagccctccaacctgctcatcaacaccacctgcgacctt
aagatttgtgatttcggcctggcccggattgccgatcctgagcatgaccacaccggcttc
ctgacggagtatgtggctacgcgctggtaccgggccccagagatcatgctgaactccaag
ggctataccaagtccatcgacatctggtctgtgggctgcattctggctgagatgctctct
aaccggcccatcttccctggcaagcactacctggatcagctcaaccacattctgggcatc
ctgggctccccatcccaggaggacctgaattgtatcatcaacatgaaggcccgaaactac
ctacagtctctgccctccaagaccaaggtggcttgggccaagcttttccccaagtcagac
tccaaagcccttgacctgctggaccggatgttaacctttaaccccaataaacggatcaca
gtggaggaagcgctggctcacccctacctggagcagtactatgacccgacggatgagcca
gtggccgaggagcccttcaccttcgccatggagctggatgacctacctaaggagcggctg
aaggagctcatcttccaggagacagcacgcttccagcccggagtgctggaggccccctag

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