KEGG   Homo sapiens (human): 5609
Entry
5609              CDS       T01001                                 
Symbol
MAP2K7, JNKK2, MAPKK7, MEK, MEK_7, MKK7, PRKMK7, SAPKK-4, SAPKK4
Name
(RefSeq) mitogen-activated protein kinase kinase 7
  KO
K04431  mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa04380  Osteoclast differentiation
hsa04530  Tight junction
hsa04620  Toll-like receptor signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04668  TNF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04912  GnRH signaling pathway
hsa04926  Relaxin signaling pathway
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05161  Hepatitis B
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06211  Other MAPK signaling (cancer)
nt06223  TNF signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06466  Pathways of neurodegeneration
nt06516  TNF signaling
nt06517  TLR signaling
nt06526  MAPK signaling
nt06534  Unfolded protein response
  Element
N00188  IL1-IL1R-JNK signaling pathway
N00189  KSHV K15 to JNK signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00446  TNF-JNK signaling pathway
N00862  Yersinia YopP/J to TLR2/4-MAPK signaling pathway
N00992  Mutation-caused aberrant Htt to TNF-JNK signaling pathway
N01013  IRE1a-JNK signaling pathway
N01014  Mutation-caused aberrant Abeta to IRE1a-JNK signaling pathway
N01125  Salmonella AvrA to TNF-JNK signaling pathway
N01407  Metals to JNK signaling pathway
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    5609 (MAP2K7)
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    5609 (MAP2K7)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    5609 (MAP2K7)
   04660 T cell receptor signaling pathway
    5609 (MAP2K7)
   04664 Fc epsilon RI signaling pathway
    5609 (MAP2K7)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    5609 (MAP2K7)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    5609 (MAP2K7)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    5609 (MAP2K7)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    5609 (MAP2K7)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    5609 (MAP2K7)
   05161 Hepatitis B
    5609 (MAP2K7)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5609 (MAP2K7)
   05169 Epstein-Barr virus infection
    5609 (MAP2K7)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    5609 (MAP2K7)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5609 (MAP2K7)
   05016 Huntington disease
    5609 (MAP2K7)
   05022 Pathways of neurodegeneration - multiple diseases
    5609 (MAP2K7)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5609 (MAP2K7)
   05418 Fluid shear stress and atherosclerosis
    5609 (MAP2K7)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    5609 (MAP2K7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5609 (MAP2K7)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     5609 (MAP2K7)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: STE group
  STE7 family
   5609 (MAP2K7)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Pkinase_fungal Seadorna_VP7 Haspin_kinase APH RIO1
Other DBs
NCBI-GeneID: 5609
NCBI-ProteinID: NP_660186
OMIM: 603014
HGNC: 6847
Ensembl: ENSG00000076984
UniProt: O14733
Structure
Position
19:7903877..7914478
AA seq 419 aa
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
NT seq 1260 nt   +upstreamnt  +downstreamnt
atggcggcgtcctccctggaacagaagctgtcccgcctggaagcaaagctgaagcaggag
aaccgggaggcccggcggaggatcgacctcaacctggatatcagcccccagcggcccagg
cccaccctgcagctcccgctggccaacgatgggggcagccgctcgccatcctcagagagc
tccccgcagcaccccacgccccccgcccggccccgccacatgctggggctcccgtcaacc
ctgttcacaccccgcagcatggagagcattgagattgaccagaagctgcaggagatcatg
aagcagacgggctacctgaccatcgggggccagcgctaccaggcagaaatcaacgacctg
gagaacttgggcgagatgggcagcggcacctgcggccaggtgtggaagatgcgcttccgg
aagaccggccacgtcattgccgttaagcaaatgcggcgctccgggaacaaggaggagaac
aagcgcatcctcatggacctggatgtggtgctgaagagccacgactgcccctacatcgtg
cagtgctttgggacgttcatcaccaacacggacgtcttcatcgccatggagctcatgggc
acctgcgctgagaagctcaagaagcggatgcagggccccatccccgagcgcattctgggc
aagatgacagtggcgattgtgaaggcgctgtactacctgaaggagaagcacggtgtcatc
caccgcgacgtcaagccctccaacatcctgctggacgagcggggccagatcaagctctgc
gacttcggcatcagcggccgcctggtggactccaaagccaagacgcggagcgccggctgt
gccgcctacatggcacccgagcgcattgaccccccagaccccaccaagccggactatgac
atccgggccgacgtatggagcctgggcatctcgttggtggagctggcaacaggacagttt
ccctacaagaactgcaagacggactttgaggtcctcaccaaagtcctacaggaagagccc
ccgcttctgcccggacacatgggcttctcgggggacttccagtccttcgtcaaagactgc
cttactaaagatcacaggaagagaccaaagtataataagctacttgaacacagcttcatc
aagcgctacgagacgctggaggtggacgtggcgtcctggttcaaggatgtcatggcgaag
actgagtcaccgcggactagcggcgtcctgagccagccccacctgcccttcttcaggtag

  All links  
Disease (1)   
   OMIM (1)   
Gene (16)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   NAGAHAMA-H (2)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (35)   
   RefSeq(nuc) (5)   
   GenBank (15)   
   EMBL (15)   
3D Structure (36)   
   PDB (36)   
Protein domain (9)   
   Pfam (9)   
All databases (104)   

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