Entry |
|
Symbol |
EIF2AK2, DYT33, EIF2AK1, LEUDEN, PKR, PPP1R83, PRKR
|
Name |
(RefSeq) eukaryotic translation initiation factor 2 alpha kinase 2
|
KO |
K16195 | eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1] |
|
Organism |
|
Pathway |
hsa04141 | Protein processing in endoplasmic reticulum |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05168 | Herpes simplex virus 1 infection |
|
Network |
nt06122 IFN signaling (viruses) nt06138 PKR-eIF2alpha signaling (viruses) nt06162 Hepatitis B virus (HBV) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06166 Human papillomavirus (HPV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06170 Influenza A virus (IAV) nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nt06222 IFN signaling nt06263 Hepatocellular carcinoma |
Element |
N00150 | Type I IFN signaling pathway |
N00571 | PKR-eIF2alpha signaling pathway |
N00573 | HSV US11 to PKR-eIF2alpha signaling pathway |
N00696 | MV C to PKR-eIF2alpha signaling pathway |
N00725 | IAV NS1 to PKR-eIF2alpha signaling pathway |
N00726 | IAV NP to PKR-eIF2alpha signaling pathway |
|
Disease |
H02457 | Developmental delay, leukoencephalopathy, and neurologic decompensation |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
5610 (EIF2AK2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
5610 (EIF2AK2)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
5610 (EIF2AK2)
09172 Infectious disease: viral
05160 Hepatitis C
5610 (EIF2AK2)
05171 Coronavirus disease - COVID-19
5610 (EIF2AK2)
05164 Influenza A
5610 (EIF2AK2)
05162 Measles
5610 (EIF2AK2)
05168 Herpes simplex virus 1 infection
5610 (EIF2AK2)
05167 Kaposi sarcoma-associated herpesvirus infection
5610 (EIF2AK2)
05169 Epstein-Barr virus infection
5610 (EIF2AK2)
05165 Human papillomavirus infection
5610 (EIF2AK2)
09164 Neurodegenerative disease
05010 Alzheimer disease
5610 (EIF2AK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
5610 (EIF2AK2)
01009 Protein phosphatases and associated proteins [BR:hsa01009]
5610 (EIF2AK2)
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:hsa03019]
5610 (EIF2AK2)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
5610 (EIF2AK2)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
PEK family [OT]
5610 (EIF2AK2)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
5610 (EIF2AK2)
Messenger RNA biogenesis [BR:hsa03019]
Eukaryotic type
mRNA surveillance and transport factors
mRNA cycle factors
P-body specific factors
5610 (EIF2AK2)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
2:complement(37099210..37156980)
|
AA seq |
551 aa
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC |
NT seq |
1656 nt +upstreamnt +downstreamnt
atggctggtgatctttcagcaggtttcttcatggaggaacttaatacataccgtcagaag
cagggagtagtacttaaatatcaagaactgcctaattcaggacctccacatgataggagg
tttacatttcaagttataatagatggaagagaatttccagaaggtgaaggtagatcaaag
aaggaagcaaaaaatgccgcagccaaattagctgttgagatacttaataaggaaaagaag
gcagttagtcctttattattgacaacaacgaattcttcagaaggattatccatggggaat
tacataggccttatcaatagaattgcccagaagaaaagactaactgtaaattatgaacag
tgtgcatcgggggtgcatgggccagaaggatttcattataaatgcaaaatgggacagaaa
gaatatagtattggtacaggttctactaaacaggaagcaaaacaattggccgctaaactt
gcatatcttcagatattatcagaagaaacctcagtgaaatctgactacctgtcctctggt
tcttttgctactacgtgtgagtcccaaagcaactctttagtgaccagcacactcgcttct
gaatcatcatctgaaggtgacttctcagcagatacatcagagataaattctaacagtgac
agtttaaacagttcttcgttgcttatgaatggtctcagaaataatcaaaggaaggcaaaa
agatctttggcacccagatttgaccttcctgacatgaaagaaacaaagtatactgtggac
aagaggtttggcatggattttaaagaaatagaattaattggctcaggtggatttggccaa
gttttcaaagcaaaacacagaattgacggaaagacttacgttattaaacgtgttaaatat
aataacgagaaggcggagcgtgaagtaaaagcattggcaaaacttgatcatgtaaatatt
gttcactacaatggctgttgggatggatttgattatgatcctgagaccagtgatgattct
cttgagagcagtgattatgatcctgagaacagcaaaaatagttcaaggtcaaagactaag
tgccttttcatccaaatggaattctgtgataaagggaccttggaacaatggattgaaaaa
agaagaggcgagaaactagacaaagttttggctttggaactctttgaacaaataacaaaa
ggggtggattatatacattcaaaaaaattaattcatagagatcttaagccaagtaatata
ttcttagtagatacaaaacaagtaaagattggagactttggacttgtaacatctctgaaa
aatgatggaaagcgaacaaggagtaagggaactttgcgatacatgagcccagaacagatt
tcttcgcaagactatggaaaggaagtggacctctacgctttggggctaattcttgctgaa
cttcttcatgtatgtgacactgcttttgaaacatcaaagtttttcacagacctacgggat
ggcatcatctcagatatatttgataaaaaagaaaaaactcttctacagaaattactctca
aagaaacctgaggatcgacctaacacatctgaaatactaaggaccttgactgtgtggaag
aaaagcccagagaaaaatgaacgacacacatgttag |