KEGG   Homo sapiens (human): 5710
Entry
5710              CDS       T01001                                 

Gene name
PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5
Definition
(RefSeq) proteasome 26S subunit ubiquitin receptor, non-ATPase 4
  KO
K03029  26S proteasome regulatory subunit N10
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5710 (PSMD4)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5710 (PSMD4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5710 (PSMD4)
   05012 Parkinson disease
    5710 (PSMD4)
   05014 Amyotrophic lateral sclerosis
    5710 (PSMD4)
   05016 Huntington disease
    5710 (PSMD4)
   05017 Spinocerebellar ataxia
    5710 (PSMD4)
   05020 Prion disease
    5710 (PSMD4)
   05022 Pathways of neurodegeneration - multiple diseases
    5710 (PSMD4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5710 (PSMD4)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5710 (PSMD4)
SSDB
Motif
Pfam: VWA_2 VWA Ssl1 UIM RAP80_UIM
Other DBs
NCBI-GeneID: 5710
NCBI-ProteinID: NP_002801
OMIM: 601648
HGNC: 9561
Ensembl: ENSG00000159352
Vega: OTTHUMG00000012349
Pharos: P55036(Tbio)
UniProt: P55036
Structure
PDB: 

Position
1q21.3
AA seq 377 aa
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEV
LTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDN
EKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLA
DALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAA
ASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEF
GQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLA
SQATKDGKKDKKEEDKK
NT seq 1134 nt   +upstreamnt  +downstreamnt
atggtgttggaaagcactatggtgtgtgtggacaacagtgagtatatgcggaatggagac
ttcttacccaccaggctgcaggcccagcaggatgctgtcaacatagtttgtcattcaaag
acccgcagcaaccctgagaacaacgtgggccttatcacactggctaatgactgtgaagtg
ctgaccacactcaccccagacactggccgtatcctgtccaagctacatactgtccaaccc
aagggcaagatcaccttctgcacgggcatccgcgtggcccatctggctctgaagcaccga
caaggcaagaatcacaagatgcgcatcattgcctttgtgggaagcccagtggaggacaat
gagaaggatctggtgaaactggctaaacgcctcaagaaggagaaagtaaatgttgacatt
atcaattttggggaagaggaggtgaacacagaaaagctgacagcctttgtaaacacgttg
aatggcaaagatggaaccggttctcatctggtgacagtgcctcctgggcccagtttggct
gatgctctcatcagttctccgattttggctggtgaaggtggtgccatgctgggtcttggt
gccagtgactttgaatttggagtagatcccagtgctgatcctgagctggccttggccctt
cgtgtatctatggaagagcagcggcagcggcaggaggaggaggcccggcgggcagctgca
gcttctgctgctgaggccgggattgctacgactgggactgaagactcagacgatgccctg
ctgaagatgaccatcagccagcaagagtttggccgcactgggcttcctgacctaagcagt
atgactgaggaagagcagattgcttatgccatgcagatgtccctgcagggagcagagttt
ggccaggcggaatcagcagacattgatgccagctcagctatggacacatctgagccagcc
aaggaggaggatgattacgacgtgatgcaggaccccgagttccttcagagtgtcctagag
aacctcccaggtgtggatcccaacaatgaagccattcgaaatgctatgggctccctggcc
tcccaggccaccaaggacggcaagaaggacaagaaggaggaagacaagaagtga

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