KEGG   Homo sapiens (human): 5714
Entry
5714              CDS       T01001                                 

Gene name
PSMD8, HEL-S-91n, HIP6, HYPF, Nin1p, Rpn12, S14, p31
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 8
  KO
K03031  26S proteasome regulatory subunit N12
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5714 (PSMD8)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5714 (PSMD8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5714 (PSMD8)
   05012 Parkinson disease
    5714 (PSMD8)
   05014 Amyotrophic lateral sclerosis
    5714 (PSMD8)
   05016 Huntington disease
    5714 (PSMD8)
   05017 Spinocerebellar ataxia
    5714 (PSMD8)
   05020 Prion disease
    5714 (PSMD8)
   05022 Pathways of neurodegeneration - multiple diseases
    5714 (PSMD8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5714 (PSMD8)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5714 (PSMD8)
SSDB
Motif
Pfam: CSN8_PSD8_EIF3K
Other DBs
NCBI-GeneID: 5714
NCBI-ProteinID: NP_002803
OMIM: 617844
HGNC: 9566
Ensembl: ENSG00000099341
Vega: OTTHUMG00000150691
Pharos: P48556(Tbio)
UniProt: P48556 V9HW09
Structure
PDB: 

Position
19q13.2
AA seq 350 aa
MFIKGRAPRAPPRERRRATRGGLRQVVAPPRALGSTSRPHFRRASVCRRRCRKSGGLLAA
SRKMAAAAVNGAAGFSSSGPAATSGAVLQAATGMYEQLKGEWNRKSPNLSKCGEELGRLK
LVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKE
QLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGS
YNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMT
DYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
NT seq 1053 nt   +upstreamnt  +downstreamnt
atgttcattaagggcagggctccgagggcgccacctcgagagcgacggcgggctacccgg
ggcgggctgaggcaggttgtagccccgccccgggccttgggctccacctctcggccccac
ttccgccgggcaagcgtttgtaggcggcgctgccgtaaatcaggcggtctgcttgccgca
tcacgcaagatggcggccgcggcggtgaacggggcggcaggcttctcgagctccgggccc
gcggcaacctcgggcgctgttctgcaggccgcgaccggcatgtacgagcaactcaagggc
gagtggaaccgtaaaagccccaatcttagcaagtgcggggaagagctgggtcgactcaag
ctagttcttctggagctcaacttcttgccaaccacagggaccaagctgaccaaacagcag
ctaattctggcccgtgacatactggagatcggggcccaatggagcatcctacgcaaggac
atcccctccttcgagcgctacatggcccagctcaaatgctactactttgattacaaggag
cagctccccgagtcagcctatatgcaccagctcttgggcctcaacctcctcttcctgctg
tcccagaaccgggtggctgagttccacacggagttggagcggctgcctgccaaggacata
cagaccaatgtctacatcaagcacccagtgtccctggagcaatacctgatggagggcagc
tacaacaaagtgttcctggccaagggtaacatccccgccgagagctacaccttcttcatt
gacatcctgctcgacactatcagggatgagatcgctgggtgcatcgagaaggcctacgag
aaaatccttttcactgaggccacccggatcctcttcttcaacacacccaaaaagatgaca
gactacgccaagaagcgagggtgggtcctgggccccaacaactactacagttttgccagc
cagcagcagaagccggaagacaccaccattccctccacagaactggccaaacaggtcatc
gagtatgcccggcagctggagatgatcgtctga

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