KEGG   Homo sapiens (human): 5739
Entry
5739              CDS       T01001                                 

Gene name
PTGIR, IP, PRIPR
Definition
(RefSeq) prostaglandin I2 receptor
  KO
K04263  prostacyclin receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04611  Platelet activation
Drug target
Beraprost (DG00160): D01551<JP> D02720
Ciprostene calcium: D03522
Clinprost: D02048
Epoprostenol (DG00157): D00106 D01337<JP/US>
Esuberaprost (DG01839): D10628 D10703 D11446
Ibudilast: D01385<JP>
Iloprost (DG00158): D02721<JP/US> D08065
Pimilprost: D01188
Ralinepag: D10725
Selexipag: D09994<JP/US>
Treprostinil (DG00161): D06213<JP/US> D08628
Treprostinil diolamine: D10430<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5739 (PTGIR)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5739 (PTGIR)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    5739 (PTGIR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    5739 (PTGIR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Prostacyclin
    5739 (PTGIR)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srsx
Other DBs
NCBI-GeneID: 5739
NCBI-ProteinID: NP_000951
OMIM: 600022
HGNC: 9602
Ensembl: ENSG00000160013
Vega: OTTHUMG00000183429
Pharos: P43119(Tclin)
UniProt: P43119
Position
19q13.32
AA seq 386 aa
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
NT seq 1161 nt   +upstreamnt  +downstreamnt
atggcggattcgtgcaggaacctcacctacgtgcggggctcggtggggccggccaccagc
accctgatgttcgtggccggtgtggtgggcaacgggctggccctgggcatcctgagcgca
cggcgaccggcgcgcccctcggccttcgcggtgctggtgaccggactggcggccaccgac
ctgctgggcaccagcttcctgagcccggccgtgttcgtggcctatgcgcgcaacagctcc
ctgctgggcctggcccgaggcggccccgccctgtgcgatgccttcgccttcgccatgacc
ttcttcggcctggcgtccatgctcatcctctttgccatggccgtggagcgctgcctggcg
ctgagccacccctacctctacgcgcagctggacgggccccgctgcgcccgcctggcgctg
ccagccatctacgccttctgcgtcctcttctgcgcgctgcccctgctgggcctgggccaa
caccagcagtactgccccggcagctggtgcttcctccgcatgcgctgggcccagccgggc
ggcgccgccttctcgctggcctacgccggcctggtggccctgctggtggctgccatcttc
ctctgcaacggctcggtcaccctcagcctctgccgcatgtaccgccagcagaagcgccac
cagggctctctgggtccacggccgcgcaccggagaggacgaggtggaccacctgatcctg
ctggccctcatgacagtggtcatggccgtgtgctccctgcctctcacgatccgctgcttc
acccaggctgtcgcccctgacagcagcagtgagatgggggacctccttgccttccgcttc
tacgccttcaaccccatcctggacccctgggtcttcatccttttccgcaaggctgtcttc
cagcgactcaagctctgggtctgctgcctgtgcctcgggcctgcccacggagactcgcag
acacccctttcccagctcgcctcagggaggagggacccaagggccccctctgctcctgtg
ggaaaggaggggagctgcgtgcctttgtcggcttggggcgaggggcaggtggagcccttg
cctcccacacagcagtccagcggcagcgccgtgggaacgtcgtccaaagcagaagccagc
gtcgcctgctccctctgctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (18)   
   KEGG DRUG (18)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (24)   
   RefSeq(nuc) (6)   
   GenBank (9)   
   EMBL (9)   
Protein domain (3)   
   Pfam (3)   
All databases (72)   

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