KEGG   Homo sapiens (human): 57580
Entry
57580             CDS       T01001                                 
Symbol
PREX1, P-REX1
Name
(RefSeq) phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
  KO
K12365  phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06224  CXCR signaling (cancer)
  Element
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    57580 (PREX1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    57580 (PREX1)
SSDB
Motif
Pfam: RhoGEF DEP INPP4A_C2 SOS1_NGEF_PH PDZ_6 PDZ PH PH_10 ECT2_PH
Other DBs
NCBI-GeneID: 57580
NCBI-ProteinID: NP_065871
OMIM: 606905
HGNC: 32594
Ensembl: ENSP00000361009.3
UniProt: Q8TCU6
Structure
Position
20:complement(48624252..48888185)
AA seq 1659 aa
MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGT
ERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYC
LHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGG
RKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINET
KRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVY
CKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWK
IHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMM
MNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVS
DKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYK
SVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEE
MEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVA
GLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLC
FQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREE
ALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSP
MVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVEN
CRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPH
PLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQH
CITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYL
QLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSD
HGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGS
GDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEF
KQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQ
LRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHC
QSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVI
FYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEK
VQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSV
GAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIM
RKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL
NT seq 4980 nt   +upstreamnt  +downstreamnt
atggaggcgcccagcggcagcgagcccggcggcgacggggccggggactgcgcccacccg
gacccccgggcccctggcgccgcggcgcccagctccggccccggcccgtgcgcggccgcc
cgggagtccgagcgccagctgcgcctccgcctctgcgtcctcaacgagatcttgggcacc
gagagggactacgtgggcaccttgcgcttcttgcagtcggcattcctgcatcgcatccgg
cagaacgtggccgactcagtggagaagggcctcacggaggagaatgtcaaggtcctgttc
tcgaacatcgaagacatcctggaagttcataaggatttcttggccgccttggagtattgt
ttacacccggagccgcagtctcagcatgaacttgggaatgttttcttaaaattcaaggac
aagttctgcgtgtacgaggagtattgcagcaaccatgagaaagccctgaggctgctggtg
gagctgaacaagatccctaccgtgcgcgccttccttttgagctgcatgcttctgggaggc
cggaagaccacggacatccctttggaaggctacctgttgtctccgatccagaggatctgc
aagtacccgctcctccttaaggagctggccaagaggactcccggcaagcacccagaccac
cccgcggtccagagtgccctgcaggccatgaagaccgtttgctccaacatcaatgagacc
aagcggcagatggagaagctggaagccctggagcagctgcagtcccacatcgaaggctgg
gagggttccaacctcacagacatctgcactcagctcctcctgcaagggactttgttaaag
atctctgcgggcaacatccaggaaagggccttcttcctcttcgacaaccttctcgtctac
tgcaagcggaaatccagggtcaccgggagcaagaagtccaccaagaggaccaaatccatc
aacggctccctctacatcttcaggggtcgaatcaacactgaagtcatggaggtggagaat
gtggaagatgggacagcggattaccatagcaacggctataccgtcaccaacggctggaag
atccacaacacggccaagaataagtggtttgtctgcatggccaagacggcagaggagaag
cagaagtggctggatgccatcatccgcgagcgggagcagcgcgagagcctgaagctgggc
atggagcgtgatgcctacgtcatgattgcggagaagggggagaagctgtaccacatgatg
atgaacaagaaggtgaacctcatcaaggaccgccggagaaagctgagcactgtccccaag
tgctttcttggcaatgagttcgttgcctggctcctagaaattggtgaaatcagcaagacg
gaagaaggagtcaacttgggccaagccctgttggagaatggcatcatccaccatgtttcc
gacaagcaccagttcaagaatgagcaggtgatgtatcgcttccgctacgacgatggcacc
tacaaggcccgaagtgagctggaggacatcatgtccaagggtgtgaggctttactgccgt
cttcacagcctctacaccccggtgatcaaagaccgtgattaccacctgaagacctacaag
tcagtgcttcccgggagcaagctggtggactggctgctggctcagggagactgccagact
cgggaggaggcagtggcgctcggcgtgggtctgtgcaacaatggcttcatgcaccacgtg
ctggagaagagcgagttcagggatgagtcccagtacttccgctttcatgctgacgaggag
atggaggggaccagcagcaagaacaaacagcttcgcaacgacttcaagctggtggagaac
attctggccaagcgcctgctgatcctgccccaggaggaggactatggctttgacatcgag
gagaagaacaaggctgtggtggtgaagtccgtccagaggggctcgctggctgaggtggct
ggcctgcaggtggggaggaagatctactccatcaatgaggacctggtgttcctgcggccg
ttttcagaggtggagtccatcctcaaccagtccttctgctcccgccgccctctgcgcctc
ctggtggccacgaaggccaaagagatcatcaaaatccccgaccagccggacacactgtgc
ttccagattcgtggagctgccccaccgtacgtctatgctgtggggagaggctctgaggcc
atggctgcagggctctgtgctggtcagtgcattctgaaggtcaatggcagcaacgtgatg
aacgatggtgcccctgaggtcctggagcacttccaggcattccggagtcggcgcgaagag
gccctgggcctgtaccagtggatctaccacacccatgaggatgcccaggaagcacgagcc
agtcaggaggcctccactgaggaccccagtggcgagcaggcccaggaggaagaccaggct
gattcagccttcccactgctgtccctgggtccccggctgagcctgtgtgaggacagcccc
atggtcaccctgactgtggacaacgtgcacctggaacacggcgtggtgtatgagtatgtg
agcacggcaggcgtcaggtgccatgtgctggagaagatcgtggagccccgcggctgcttc
ggcctcaccgccaagatcctcgaggcctttgctgccaatgacagcgtcttcgtggagaac
tgcaggcggctcatggccctgagcagcgccatcgtgaccatgccccactttgagttccgc
aacatctgtgacaccaagctggagagcattggccagaggattgcctgctaccaggagttt
gcagcccaactgaagagcagggtcagcccacccttcaaacaagcccccctggagccccac
ccgctgtgtggcctggacttctgccccaccaattgccacatcaacctcatggaagtgtcc
taccccaagaccaccccctcagtgggcaggtccttcagcatccgctttggacgcaaaccc
tccctcatcggccttgacccggagcaaggccacctgaaccccatgtcgtacacccagcac
tgcatcaccaccatggctgctccctcctggaagtgcttgcctgctgcagagggtgatccc
caaggccagggtctccatgatggcagcttcgggccagccagtgggacccttggtcaggaa
gaccggggcctcagcttcctactcaagcaggaggaccgtgagatccaggatgcctacctg
cagctcttcaccaagctggatgtggccctgaaggagatgaagcaatatgtcacccagatc
aacaggctgctgtccaccatcacagagcccacctcgggtgggtcctgcgacgcatccttg
gctgaggaggcctcctccctgcccctggtcagtgaagagagcgagatggacaggagtgac
catgggggcatcaagaaggtgtgcttcaaggtggccgaggaggaccaggaggactcaggc
cacgacaccatgagttatcgcgactcctacagcgagtgtaacagcaatcgagactcggtc
ctgtcctacaccagcgtgagaagtaacagctcctacttgggcagcgacgagatggggtct
ggagatgagctgccctgtgacatgcggatcccatctgacaagcaggacaagcttcatggc
tgcctggagcacctctttaaccaggtggactccatcaatgctctcctcaaggggccagtc
atgagccgggctttcgaagagaccaagcatttccctatgaaccacagcttacaagagttt
aaacagaaagaagagtgtacaatccgtggccggagcctgatccagattagcatccaggag
gacccctggaacctccccaactccatcaagaccctggtggacaacattcagagatatgtg
gaagatgggaagaaccagctgctcctggccttgctgaagtgcacagacacggagctgcag
ctgcgcagagacgcgatcttctgccaggccctggtggccgccgtgtgcaccttctccaag
cagctgctggcggccctgggctaccgctacaacaacaatggcgagtacgaggagagcagc
cgcgacgccagccgcaagtggctggagcaggtggcggccacgggcgtcctgctgcactgc
cagtccctgctctcgccagccacagtgaaggaggaacggaccatgctggaggacatctgg
gtgacgctgtcagagctggacaatgtcaccttctcctttaagcagctggacgagaactat
gtggccaacaccaacgtcttctaccacattgagggcagccggcaggcgctgaaggtcatc
ttctacctcgacagctaccacttctccaagctgccctcccgcctggagggtggggccagc
ctgaggctgcacacagcgctgttcacgaaagtgctggagaacgtggaggggctgccttct
ccaggcagccaggccgcggaggatttgcagcaggacatcaacgcgcagtccctggagaaa
gttcagcagtattaccgcaaactcagggcattttacctggagcggtctaacctgcccacg
gatgccagcaccacggcggtaaagatagaccagctgatccgccccatcaatgccctggat
gagctctgccgcctcatgaagtcctttgtccacccaaagcctggtgctgctgggagtgtg
ggcgccggcctcatccccatctcctcggagctctgctaccgcctgggggcctgccagatg
gtcatgtgtggcacaggcatgcagaggagcaccctgagcgtgtccctggagcaggcggcc
atcttggcacggagccacgggttgctgcccaagtgcatcatgcaggccacggacatcatg
cggaagcagggcccaagggtggagattctggccaaaaacctgcgagtcaaggaccagatg
ccccagggtgctccgcgcctctaccgcctctgccagccgccggtggatggggacctctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (17)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (23)   
   RefSeq(nuc) (9)   
   GenBank (7)   
   EMBL (7)   
3D Structure (14)   
   PDB (14)   
Protein domain (9)   
   Pfam (9)   
All databases (75)   

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