| Entry |
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| Symbol |
PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
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| Name |
(RefSeq) protein tyrosine phosphatase non-receptor type 11
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| KO |
| K07293 | tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48] |
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| Organism |
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| Pathway |
| hsa04072 | Phospholipase D signaling pathway |
| hsa04625 | C-type lectin receptor signaling pathway |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04660 | T cell receptor signaling pathway |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04920 | Adipocytokine signaling pathway |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa05168 | Herpes simplex virus 1 infection |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
| hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
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| Network |
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| Element |
| N00926 | Escherichia Tir to TLR2/4-MAPK signaling pathway |
| N01165 | PDL/PD1-SHP-PI3K signaling pathway |
| N01411 | Metals to NFKB signaling pathway |
| N01595 | Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins |
| N01786 | Don't eat me signal (CD24) |
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| Disease |
| H00523 | Noonan syndrome and related disorders |
| H02410 | Myelodysplastic/myeloproliferative neoplasms |
| H02541 | Juvenile myelomonocytic leukemia |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
5781 (PTPN11)
04630 JAK-STAT signaling pathway
5781 (PTPN11)
04072 Phospholipase D signaling pathway
5781 (PTPN11)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
5781 (PTPN11)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
5781 (PTPN11)
04660 T cell receptor signaling pathway
5781 (PTPN11)
04670 Leukocyte transendothelial migration
5781 (PTPN11)
09156 Nervous system
04722 Neurotrophin signaling pathway
5781 (PTPN11)
09158 Development and regeneration
04360 Axon guidance
5781 (PTPN11)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
5781 (PTPN11)
05208 Chemical carcinogenesis - reactive oxygen species
5781 (PTPN11)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5781 (PTPN11)
09162 Cancer: specific types
05220 Chronic myeloid leukemia
5781 (PTPN11)
05211 Renal cell carcinoma
5781 (PTPN11)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
5781 (PTPN11)
05130 Pathogenic Escherichia coli infection
5781 (PTPN11)
09167 Endocrine and metabolic disease
04931 Insulin resistance
5781 (PTPN11)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:hsa01009]
5781 (PTPN11)
Enzymes [BR:hsa01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.48 protein-tyrosine-phosphatase
5781 (PTPN11)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein tyrosine phosphatases (PTPs)
Class I PTPs (Classical)
Non-receptor PTPs
5781 (PTPN11)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
12:112418947..112509918
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| AA seq |
593 aa
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR |
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| NT seq |
1782 nt +upstreamnt +downstreamnt
atgacatcgcggagatggtttcacccaaatatcactggtgtggaggcagaaaacctactg
ttgacaagaggagttgatggcagttttttggcaaggcctagtaaaagtaaccctggagac
ttcacactttccgttagaagaaatggagctgtcacccacatcaagattcagaacactggt
gattactatgacctgtatggaggggagaaatttgccactttggctgagttggtccagtat
tacatggaacatcacgggcaattaaaagagaagaatggagatgtcattgagcttaaatat
cctctgaactgtgcagatcctacctctgaaaggtggtttcatggacatctctctgggaaa
gaagcagagaaattattaactgaaaaaggaaaacatggtagttttcttgtacgagagagc
cagagccaccctggagattttgttctttctgtgcgcactggtgatgacaaaggggagagc
aatgacggcaagtctaaagtgacccatgttatgattcgctgtcaggaactgaaatacgac
gttggtggaggagaacggtttgattctttgacagatcttgtggaacattataagaagaat
cctatggtggaaacattgggtacagtactacaactcaagcagccccttaacacgactcgt
ataaatgctgctgaaatagaaagcagagttcgagaactaagcaaattagctgagaccaca
gataaagtcaaacaaggcttttgggaagaatttgagacactacaacaacaggagtgcaaa
cttctctacagccgaaaagagggtcaaaggcaagaaaacaaaaacaaaaatagatataaa
aacatcctgccctttgatcataccagggttgtcctacacgatggtgatcccaatgagcct
gtttcagattacatcaatgcaaatatcatcatgcctgaatttgaaaccaagtgcaacaat
tcaaagcccaaaaagagttacattgccacacaaggctgcctgcaaaacacggtgaatgac
ttttggcggatggtgttccaagaaaactcccgagtgattgtcatgacaacgaaagaagtg
gagagaggaaagagtaaatgtgtcaaatactggcctgatgagtatgctctaaaagaatat
ggcgtcatgcgtgttaggaacgtcaaagaaagcgccgctcatgactatacgctaagagaa
cttaaactttcaaaggttggacaagggaatacggagagaacggtctggcaataccacttt
cggacctggccggaccacggcgtgcccagcgaccctgggggcgtgctggacttcctggag
gaggtgcaccataagcaggagagcatcatggatgcagggccggtcgtggtgcactgcagt
gctggaattggccggacagggacgttcattgtgattgatattcttattgacatcatcaga
gagaaaggtgttgactgcgatattgacgttcccaaaaccatccagatggtgcggtctcag
aggtcagggatggtccagacagaagcacagtaccgatttatctatatggcggtccagcat
tatattgaaacactacagcgcaggattgaagaagagcagaaaagcaagaggaaagggcac
gaatatacaaatattaagtattctctagcggaccagacgagtggagatcagagccctctc
ccgccttgtactccaacgccaccctgtgcagaaatgagagaagacagtgctagagtctat
gaaaacgtgggcctgatgcaacagcagaaaagtttcagatga |
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