KEGG   Homo sapiens (human): 580
Entry
580               CDS       T01001                                 
Symbol
BARD1
Name
(RefSeq) BRCA1 associated RING domain 1
  KO
K10683  BRCA1-associated RING domain protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01446  DNA end resection and RPA loading
N01452  Homologous recombination
N01466  Homologous recombination in ICLR
Disease
H00031  Breast cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    580 (BARD1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    580 (BARD1)
   04121 Ubiquitin system [BR:hsa04121]
    580 (BARD1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    580 (BARD1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    580 (BARD1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Negative regulators of mRNA 3' end processing
     580 (BARD1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   BRCC complex
    580 (BARD1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     580 (BARD1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     580 (BARD1)
SSDB
Motif
Pfam: zf-RING_6 Ank_2 Ank_4 Ank Ank_5 Ank_3 BRCT BRCT_2 zf-RING_5 ANK_LRRK2 zf-C3HC4 Ank_KRIT1 Siva zf-C3HC4_2 RTT107_BRCT_5
Other DBs
NCBI-GeneID: 580
NCBI-ProteinID: NP_000456
OMIM: 601593
HGNC: 952
Ensembl: ENSG00000138376
UniProt: Q99728 A0AVN2
Structure
Position
2:complement(214725646..214809683)
AA seq 777 aa
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY
EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV
SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP
EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP
ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS
RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV
AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
NT seq 2334 nt   +upstreamnt  +downstreamnt
atgccggataatcggcagccgaggaaccggcagccgaggatccgctccgggaacgagcct
cgttccgcgcccgccatggaaccggatggtcgcggtgcctgggcccacagtcgcgccgcg
ctcgaccgcctggagaagctgctgcgctgctcgcgttgtactaacattctgagagagcct
gtgtgtttaggaggatgtgagcacatcttctgtagtaattgtgtaagtgactgcattgga
actggatgtccagtgtgttacaccccggcctggatacaagacttgaagataaatagacaa
ctggacagcatgattcaactttgtagtaagcttcgaaatttgctacatgacaatgagctg
tcagatttgaaagaagataaacctaggaaaagtttgtttaatgatgcaggaaacaagaag
aattcaattaaaatgtggtttagccctcgaagtaagaaagtcagatatgttgtgagtaaa
gcttcagtgcaaacccagcctgcaataaaaaaagatgcaagtgctcagcaagactcatat
gaatttgtttccccaagtcctcctgcagatgtttctgagagggctaaaaaggcttctgca
agatctggaaaaaagcaaaaaaagaaaactttagctgaaatcaaccaaaaatggaattta
gaggcagaaaaagaagatggtgaatttgactccaaagaggaatctaagcaaaagctggta
tccttctgtagccaaccatctgttatctccagtcctcagataaatggtgaaatagactta
ctagcaagtggctccttgacagaatctgaatgttttggaagtttaactgaagtctcttta
ccattggctgagcaaatagagtctccagacactaagagcaggaatgaagtagtgactcct
gagaaggtctgcaaaaattatcttacatctaagaaatctttgccattagaaaataatgga
aaacgtggccatcacaatagactttccagtcccatttctaagagatgtagaaccagcatt
ctgagcaccagtggagattttgttaagcaaacggtgccctcagaaaatataccattgcct
gaatgttcttcaccaccttcatgcaaacgtaaagttggtggtacatcagggaggaaaaac
agtaacatgtccgatgaattcattagtctttcaccaggtacaccaccttctacattaagt
agttcaagttacaggcgagtgatgtctagtccctcagcaatgaagctgttgcccaatatg
gctgtgaaaagaaatcatagaggagagactttgctccatattgcttctattaagggcgac
ataccttctgttgaataccttttacaaaatggaagtgatccaaatgttaaagaccatgct
ggatggacaccattgcatgaagcttgcaatcatgggcacctgaaggtagtggaattattg
ctccagcataaggcattggtgaacaccaccgggtatcaaaatgactcaccacttcacgat
gcagccaagaatgggcatgtggatatagtcaagctgttactttcctatggagcctccaga
aatgctgttaatatatttggtctgcggcctgtcgattatacagatgatgaaagtatgaaa
tcgctattgctgctaccagagaagaatgaatcatcctcagctagccactgctcagtaatg
aacactgggcagcgtagggatggacctcttgtacttataggcagtgggctgtcttcagaa
caacagaaaatgctcagtgagcttgcagtaattcttaaggctaaaaaatatactgagttt
gacagtacagtaactcatgttgttgttcctggtgatgcagttcaaagtaccttgaagtgt
atgcttgggattctcaatggatgctggattctaaaatttgaatgggtaaaagcatgtcta
cgaagaaaagtatgtgaacaggaagaaaagtatgaaattcctgaaggtccacgcagaagc
aggctcaacagagaacagctgttgccaaagctgtttgatggatgctacttctatttgtgg
ggaaccttcaaacaccatccaaaggacaaccttattaagctcgtcactgcaggtgggggc
cagatcctcagtagaaagcccaagccagacagtgacgtgactcagaccatcaatacagtc
gcataccatgcgagacccgattctgatcagcgcttctgcacacagtatatcatctatgaa
gatttgtgtaattatcacccagagagggttcggcagggcaaagtctggaaggctccttcg
agctggtttatagactgtgtgatgtcctttgagttgcttcctcttgacagctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (16)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (16)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (76)   
   RefSeq(nuc) (16)   
   GenBank (30)   
   EMBL (30)   
3D Structure (11)   
   PDB (11)   
Protein domain (15)   
   Pfam (15)   
All databases (136)   

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