KEGG   Homo sapiens (human): 5831
Entry
5831              CDS       T01001                                 
Symbol
PYCR1, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR
Name
(RefSeq) pyrroline-5-carboxylate reductase 1
  KO
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
Module
hsa_M00015  Proline biosynthesis, glutamate => proline
Disease
H00557  Cutis laxa
H00558  Geroderma osteodysplasticum
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    5831 (PYCR1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.2  pyrroline-5-carboxylate reductase
     5831 (PYCR1)
SSDB
Motif
Pfam: P5CR_dimer F420_oxidored NAD_Gly3P_dh_N Rossmann-like ApbA
Other DBs
NCBI-GeneID: 5831
NCBI-ProteinID: NP_001269209
OMIM: 179035
HGNC: 9721
Ensembl: ENSG00000183010
Pharos: P32322(Tbio)
UniProt: P32322 A0A024R8U9
Structure
Position
17:complement(81932391..81937300)
AA seq 319 aa
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV
QHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRC
MTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIH
ALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTAL
SPSGHTKLLPRSLAPAGKD
NT seq 960 nt   +upstreamnt  +downstreamnt
atgagcgtgggcttcatcggcgctggccagctggcttttgccctggccaagggcttcaca
gcagcaggcgtcttggctgcccacaagataatggctagctccccagacatggacctggcc
acagtttctgctctcaggaagatgggggtgaagttgacaccccacaacaaggagacggtg
cagcacagtgatgtgctcttcctggctgtgaagccacacatcatccccttcatcctggat
gaaataggcgccgacattgaggacagacacattgtggtgtcctgcgcggccggcgtcacc
atcagctccattgagaagaagctgtcagcgtttcggccagcccccagggtcatccgctgc
atgaccaacactccagtcgtggtgcgggagggggccaccgtgtatgccacaggcacgcac
gcccaggtggaggacgggaggctcatggagcagctgctgagcagcgtgggcttctgcacg
gaggtggaagaggacctgattgatgccgtcacggggctcagtggcagcggccccgcctac
gcattcacagccctggatgccctggctgatgggggtgtgaagatgggacttccaaggcgc
ctggcagtccgcctcggggcccaggccctcctgggggctgccaagatgctgctgcactca
gaacagcacccaggccagctcaaggacaacgtcagctctcctggtggggccaccatccat
gccttgcatgtgctggagagtgggggcttccgctccctgctcatcaacgctgtggaggcc
tcctgcatccgcacacgggagctgcagtccatggctgaccaggagcaggtgtcaccagcc
gccatcaagaagaccatcctggacaaggtgaagctggactcccctgcagggaccgctctg
tcaccttctggccacaccaagctgctcccccgcagcctggccccagcgggcaaggattga

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