KEGG   Homo sapiens (human): 5836
Entry
5836              CDS       T01001                                 

Gene name
PYGL, GSD6
Definition
(RefSeq) glycogen phosphorylase L
  KO
K00688  glycogen phosphorylase [EC:2.4.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00500  Starch and sucrose metabolism
hsa01100  Metabolic pathways
hsa04217  Necroptosis
hsa04910  Insulin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04931  Insulin resistance
Module
hsa_M00855  Glycogen degradation, glycogen => glucose-6P
Network
nt06017  Glycogen metabolism
  Element
N00718  Glycogen degradation
N00719  G6PC deficiency in glycogen degradation
N00723  PYGL deficiency in glycogen degradation
Disease
H00069  Glycogen storage disease
H01760  Hepatic glycogen storage disease
H01944  Glycogen storage disease type VI
Drug target
Ingliforib: D04537
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00500 Starch and sucrose metabolism
    5836 (PYGL)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    5836 (PYGL)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    5836 (PYGL)
   04922 Glucagon signaling pathway
    5836 (PYGL)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    5836 (PYGL)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.1  glycogen phosphorylase
     5836 (PYGL)
SSDB
Motif
Pfam: Phosphorylase
Other DBs
NCBI-GeneID: 5836
NCBI-ProteinID: NP_002854
OMIM: 613741
HGNC: 9725
Ensembl: ENSG00000100504
Vega: OTTHUMG00000166596
Pharos: P06737(Tchem)
UniProt: P06737
Structure
PDB: 

Position
14q22.1
AA seq 847 aa
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
NT seq 2544 nt   +upstreamnt  +downstreamnt
atggcgaagcccctgacggaccaggagaagcggcggcagatcagcatccgcggcatcgtg
ggcgtggagaacgtggcagagctgaagaagagtttcaaccggcacctgcacttcacgctg
gtcaaggaccgcaacgtggccaccacccgcgactactacttcgcgctggcgcacacggtg
cgcgaccacctggtggggcgctggatccgcacgcagcagcactactacgacaagtgcccc
aagagggtatattacctctctctggaattttacatgggccgaacattacagaacaccatg
atcaacctcggtctgcaaaatgcctgtgatgaggccatttaccagcttggattggatata
gaagagttagaagaaattgaagaagatgctggacttggcaatggtggtcttgggagactt
gctgcctgcttcttggattccatggcaaccctgggacttgcagcctatggatacggcatt
cggtatgaatatgggattttcaatcagaagatccgagatggatggcaggtagaagaagca
gatgattggctcagatatggaaacccttgggagaagtcccgcccagaattcatgctgcct
gtgcacttctatggaaaagtagaacacaccaacaccgggaccaagtggattgacactcaa
gtggtcctggctctgccatatgacacccccgtgcccggctacatgaataacactgtcaac
accatgcgcctctggtctgctcgggcaccaaatgactttaacctcagagactttaatgtt
ggagactacattcaggctgtgctggaccgaaacctggccgagaacatctcccgggtcctc
tatcccaatgacaatttttttgaagggaaggagctaagattgaagcaggaatactttgtg
gtggctgcaaccttgcaagatatcatccgccgtttcaaagcctccaagtttggctccacc
cgtggtgcaggaactgtgtttgatgccttcccggatcaggtggccatccagctgaatgac
actcaccctgcactcgcgatccctgagctgatgaggatttttgtggatattgaaaaactg
ccctggtccaaggcatgggagctcacccagaagaccttcgcctacaccaaccacacagtg
ctcccggaagccctggagcgctggcccgtggacctggtggagaagctgctccctcgacat
ttggaaatcatttatgagataaatcagaagcatttagatagaattgtggccttgtttcct
aaagatgtggaccgtctgagaaggatgtctctgatagaagaggaaggaagcaaaaggatc
aacatggcccatctctgcattgtcggttcccatgctgtgaatggcgtggctaaaatccac
tcagacatcgtgaagactaaagtattcaaggacttcagtgagctagaacctgacaagttt
cagaataaaaccaatgggatcactccaaggcgctggctcctactctgcaacccaggactt
gcagagctcatagcagagaaaattggagaagactatgtgaaagacctgagccagctgacg
aagctccacagcttcctgggtgatgatgtcttcctccgggaactcgccaaggtgaagcag
gagaataagctgaagttttctcagttcctggagacggagtacaaagtgaagatcaaccca
tcctccatgtttgatgtccaggtgaagaggatacatgagtacaagcgacagctcttgaac
tgtctgcatgtgatcacgatgtacaaccgcattaagaaagaccctaagaagttattcgtg
ccaaggacagttatcattggtggtaaagctgccccaggatatcacatggccaaaatgatc
ataaagctgatcacttcagtggcagatgtggtgaacaatgaccctatggttggaagcaag
ttgaaagtcatcttcttggagaactacagagtatctcttgctgaaaaagtcattccagcc
acagatctgtcagagcagatttccactgcaggcaccgaagcctcggggacaggcaatatg
aagttcatgctaaatggggccctaactatcgggaccatggatggggccaatgtggaaatg
gcagaagaagctggggaagagaacctgttcatctttggcatgaggatagatgatgtggct
gctttggacaagaaagggtacgaggcaaaagaatactatgaggcacttccagagctgaag
ctggtcattgatcaaattgacaatggctttttttctcccaagcagcctgacctcttcaaa
gatatcatcaacatgctattttatcatgacaggtttaaagtctttgcagactacgaagcc
tatgtcaagtgtcaagataaagtgagtcagctgtacatgaatccaaaggcctggaacaca
atggtactcaaaaacatagctgcctcggggaaattctccagtgaccgaacaattaaagaa
tatgcccaaaacatctggaacgtggaaccttcagatctaaagatttctctatccaatgaa
tctaacaaagtcaatggaaattga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Network (3)   
   KEGG NETWORK (3)   
Disease (5)   
   KEGG DISEASE (3)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (38)   
   RefSeq(nuc) (2)   
   GenBank (18)   
   EMBL (18)   
Protein domain (1)   
   Pfam (1)   
All databases (86)   

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