KEGG   Homo sapiens (human): 58484
Entry
58484             CDS       T01001                                 
Symbol
NLRC4, AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF
Name
(RefSeq) NLR family CARD domain containing 4
  KO
K12805  NLR family CARD domain-containing protein 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04621  NOD-like receptor signaling pathway
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05134  Legionellosis
hsa05135  Yersinia infection
Network
nt06182  Shigella
nt06183  Yersinia
nt06521  NLR signaling
  Element
N00865  Yersinia YopK to NLRC4 Inflammasome signaling pathway
N00867  NLRC4 inflammasome signaling pathway
N00949  Shigella IpaB to NLRC4 Inflammasome signaling pathway
Disease
H01748  NLRC4 inflammasomopathy
H02159  Familial cold autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    58484 (NLRC4)
   05135 Yersinia infection
    58484 (NLRC4)
   05134 Legionellosis
    58484 (NLRC4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    58484 (NLRC4)
Pattern recognition receptors [BR:hsa04054]
 Cytoplasmic pattern recognition receptors
  NOD-like receptors
   58484 (NLRC4)
SSDB
Motif
Pfam: NACHT Nlrc4-like_WHD NLRC4_HD CARD LRR_14 AAA_16 AAA_29 AAA_22 LRR_EndoS
Other DBs
NCBI-GeneID: 58484
NCBI-ProteinID: NP_001186067
OMIM: 606831
HGNC: 16412
Ensembl: ENSG00000091106
UniProt: Q9NPP4
Structure
Position
2:complement(32224449..32265743)
AA seq 1024 aa
MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILK
KGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPL
GEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQ
RIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLR
QRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDM
TEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQT
TLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDV
LLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSI
SDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNT
TEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFE
HLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFR
TLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVE
ASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDA
IKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKIL
AQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLL
KHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV
FENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFK
LVTA
NT seq 3075 nt   +upstreamnt  +downstreamnt
atgaatttcataaaggacaatagccgagcccttattcaaagaatgggaatgactgttata
aagcaaatcacagatgacctatttgtatggaatgttctgaatcgcgaagaagtaaacatc
atttgctgcgagaaggtggagcaggatgctgctagagggatcattcacatgattttgaaa
aagggttcagagtcctgtaacctctttcttaaatcccttaaggagtggaactatcctcta
tttcaggacttgaatggacaaagtctttttcatcagacatcagaaggagacttggacgat
ttggctcaggatttaaaggacttgtaccataccccatcttttctgaacttttatcccctt
ggtgaagatattgacattatttttaacttgaaaagcaccttcacagaacctgtcctgtgg
aggaaggaccaacaccatcaccgcgtggagcagctgaccctgaatggcctcctgcaggct
cttcagagcccctgcatcattgaaggggaatctggcaaaggcaagtccactctgctgcag
cgaattgccatgctctggggctccggaaagtgcaaggctctgaccaagttcaaattcgtc
ttcttcctccgtctcagcagggcccagggtggactttttgaaaccctctgtgatcaactc
ctggatatacctggcacaatcaggaagcagacattcatggccatgctgctgaagctgcgg
cagagggttcttttccttcttgatggctacaatgaattcaagccccagaactgcccagaa
atcgaagccctgataaaggaaaaccaccgcttcaagaacatggtcatcgtcaccactacc
actgagtgcctgaggcacatacggcagtttggtgccctgactgctgaggtgggggatatg
acagaagacagcgcccaggctctcatccgagaagtgctgatcaaggagcttgctgaaggc
ttgttgctccaaattcagaaatccaggtgcttgaggaatctcatgaagacccctctcttt
gtggtcatcacttgtgcaatccagatgggtgaaagtgagttccactctcacacacaaaca
acgctgttccataccttctatgatctgttgatacagaaaaacaaacacaaacataaaggt
gtggctgcaagtgacttcattcggagcctggaccactgtggagacctagctctggagggt
gtgttctcccacaagtttgatttcgaactgcaggatgtgtccagcgtgaatgaggatgtc
ctgctgacaactgggctcctctgtaaatatacagctcaaaggttcaagccaaagtataaa
ttctttcacaagtcattccaggagtacacagcaggacgaagactcagcagtttattgacg
tctcatgagccagaggaggtgaccaaggggaatggttacttgcagaaaatggtttccatt
tcggacattacatccacttatagcagcctgctccggtacacctgtgggtcatctgtggaa
gccaccagggctgttatgaagcacctcgcagcagtgtatcaacacggctgccttctcgga
ctttccatcgccaagaggcctctctggagacaggaatctttgcaaagtgtgaaaaacacc
actgagcaagaaattctgaaagccataaacatcaattcctttgtagagtgtggcatccat
ttatatcaagagagtacatccaaatcagccctgagccaagaatttgaagctttctttcaa
ggtaaaagcttatatatcaactcagggaacatccccgattacttatttgacttctttgaa
catttgcccaattgtgcaagtgccctggacttcattaaactggacttttatgggggagct
atggcttcatgggaaaaggctgcagaagacacaggtggaatccacatggaagaggcccca
gaaacctacattcccagcagggctgtatctttgttcttcaactggaagcaggaattcagg
actctggaggtcacactccgggatttcagcaagttgaataagcaagatatcagatatctg
gggaaaatattcagctctgccacaagcctcaggctgcaaataaagagatgtgctggtgtg
gctggaagcctcagtttggtcctcagcacctgtaagaacatttattctctcatggtggaa
gccagtcccctcaccatagaagatgagaggcacatcacatctgtaacaaacctgaaaacc
ttgagtattcatgacctacagaatcaacggctgccgggtggtctgactgacagcttgggt
aacttgaagaaccttacaaagctcataatggataacataaagatgaatgaagaagatgct
ataaaactagctgaaggcctgaaaaacctgaagaagatgtgtttatttcatttgacccac
ttgtctgacattggagagggaatggattacatagtcaagtctctgtcaagtgaaccctgt
gaccttgaagaaattcaattagtctcctgctgcttgtctgcaaatgcagtgaaaatccta
gctcagaatcttcacaatttggtcaaactgagcattcttgatttatcagaaaattacctg
gaaaaagatggaaatgaagctcttcatgaactgatcgacaggatgaacgtgctagaacag
ctcaccgcactgatgctgccctggggctgtgacgtgcaaggcagcctgagcagcctgttg
aaacatttggaggaggtcccacaactcgtcaagcttgggttgaaaaactggagactcaca
gatacagagattagaattttaggtgcattttttggaaagaaccctctgaaaaacttccag
cagttgaatttggcgggaaatcgtgtgagcagtgatggatggcttgccttcatgggtgta
tttgagaatcttaagcaattagtgttttttgactttagtactaaagaatttctacctgat
ccagcattagtcagaaaacttagccaagtgttatccaagttaacttttctgcaagaagct
aggcttgttgggtggcaatttgatgatgatgatctcagtgttattacaggtgcttttaaa
ctagtaactgcttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (6)   
   KEGG NETWORK (6)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (36)   
   RefSeq(nuc) (6)   
   GenBank (15)   
   EMBL (15)   
3D Structure (6)   
   PDB (6)   
Protein domain (9)   
   Pfam (9)   
All databases (98)   

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