KEGG   Homo sapiens (human): 5859
Entry
5859              CDS       T01001                                 

Symbol
QARS1, GLNRS, MSCCA, PRO2195, QARS
Name
(RefSeq) glutaminyl-tRNA synthetase 1
  KO
K01886  glutaminyl-tRNA synthetase [EC:6.1.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
hsa01100  Metabolic pathways
Disease
H02132  Microcephaly syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    5859 (QARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    5859 (QARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    5859 (QARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.18  glutamine---tRNA ligase
     5859 (QARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (A)
   5859 (QARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    5859 (QARS1)
 Prokaryotic type
   Other AARSs
    5859 (QARS1)
SSDB
Motif
Pfam: tRNA-synt_1c tRNA_synt_1c_R1 tRNA-synt_1c_C tRNA_synt_1c_R2
Other DBs
NCBI-GeneID: 5859
NCBI-ProteinID: NP_005042
OMIM: 603727
HGNC: 9751
Ensembl: ENSG00000172053
Vega: OTTHUMG00000156774
Pharos: P47897(Tchem)
UniProt: P47897 B7Z840
Structure
PDB: 
4YE6 4YE9 4YE8 4R3Z

Position
3p21.31
AA seq 775 aa
MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLA
SRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPE
QIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPK
LEADLEKKFKVAKARLEETDRRTAKDVVENGETADQTLSLMEQLRGEALKFHKPGENYKT
PGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFL
RFDDTNPEKEEAKFFTAICDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRGLAYVCHQ
RGEELKGHNTLPSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKMDPVAYRV
KYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPV
QWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVG
VTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADET
KGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVES
LEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLASL
HVVDAALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGKLVFNRTVTLKEDPGKV
NT seq 2328 nt   +upstreamnt  +downstreamnt
atggcggctctagactccctgtcgctcttcactagcctcggcctgagcgagcagaaggcc
cgcgagacgctcaagaactcggctctgagcgcgcagctgcgcgaggccgctactcaggct
cagcagaccctgggttccaccattgacaaagctaccgggatcctgttatatggcttggcc
tcccgactcagggatacccggcgtctctccttccttgtaagctacatagccagtaagaag
atccacactgagccccagctaagcgctgcccttgagtatgtgcggagtcaccccttggac
cccatcgacactgtggacttcgagcgggaatgtggcgtgggtgtcattgtgaccccagag
cagattgaggaggctgtggaggctgctattaacaggcaccggccccagctcctggtggaa
cgttaccatttcaacatggggctgctgatgggagaggctcgggctgtgctgaagtgggca
gatggcaaaatgatcaagaatgaagtggacatgcaggtcctccaccttctgggccccaag
ttggaggctgatctggagaagaagttcaaggtggcaaaagctcggctagaagaaacagac
cggaggacggcaaaggatgtggtggagaatggcgagactgctgaccagaccctgtctctg
atggagcagctccggggggaggcccttaagttccacaagcctggtgagaactacaagacc
ccaggctatgtggtcactccacacaccatgaatctactaaagcagcacctggagattact
ggtgggcaggtacgtacccggttcccgccagaacccaatggaatcctgcatattggacat
gccaaagccatcaatttcaactttggctatgccaaggccaacaatggcatctgttttctg
cgttttgatgacaccaaccctgagaaggaggaagcaaagttcttcacggccatctgtgac
atggtagcctggctaggctacacaccttacaaagtcacatatgcgtctgactattttgac
cagctatatgcgtgggctgtggagctcatccgcaggggtctggcttatgtgtgccaccag
cgaggagaggagctcaaaggccataatactctgccttcaccctggagagaccgtcccatg
gaggagtcactgctgctctttgaggcaatgcgcaagggcaagttttcagagggcgaggcc
acactacggatgaagctggtgatggaggatggcaagatggaccctgtagcctatcgagtc
aagtatacaccacaccaccgcacaggggacaaatggtgcatctatcccacctacgactac
acacactgcctctgtgactccatcgagcacatcactcactcactctgcaccaaggaattc
caggcccgacgctcttcctacttctggctttgcaatgcactggacgtctattgccctgtg
cagtgggagtatggccgcctcaacctgcactatgctgttgtctctaagaggaagatcctc
cagcttgtagcaactggtgctgtgcgggactgggatgacccacggctctttacactcacg
gccctgcgacggcggggcttcccacctgaggccatcaacaacttctgtgcccgggtggga
gtgactgtggcacaaaccacaatggagccacatcttctagaagcctgtgtgcgtgatgtg
ctgaatgacacagccccacgagccatggctgtgctggagtcactacgggtcatcatcacc
aactttcctgctgccaagtccttggacatccaggtgcccaacttcccagctgatgagacc
aaaggcttccatcaggttccctttgcacccattgtcttcattgagaggactgacttcaag
gaggagccagagccaggatttaagcgcctggcttggggccagcctgtgggcctgaggcat
acaggctacgtcattgagctgcagcatgttgtcaagggccccagtggttgtgtagagagt
ctggaggtgacctgcagacgggcagatgctggagagaagccaaaggcctttattcactgg
gtgtcacagcctttgatgtgtgaggttcgcctctatgagcgactattccagcacaagaac
cctgaagatcctactgaggtgcctggtggatttttaagtgacctgaacctggcatcacta
cacgtggtggatgcagcattagtggactgctctgtggccctggcaaaacccttcgacaag
ttccagtttgagcgtcttggatatttctccgtggatccagacagccatcagggaaagctt
gtctttaaccgaactgtcacactgaaggaagacccaggaaaggtgtga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (16)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (40)   
   RefSeq(nuc) (4)   
   GenBank (18)   
   EMBL (18)   
Protein domain (4)   
   Pfam (4)   
All databases (96)   

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