KEGG   Homo sapiens (human): 590
Entry
590               CDS       T01001                                 
Symbol
BCHE, BCHED, CHE1, CHE2, E1
Name
(RefSeq) butyrylcholinesterase
  KO
K01050  cholinesterase [EC:3.1.1.8]
Organism
hsa  Homo sapiens (human)
Disease
H02432  Butyrylcholinesterase deficiency
Drug target
Ecothiopate (DG01131): D02193<US>
Fluostigmine: D00043
Hexafluronium: D04435
Ladostigil tartrate: D03239
Rivastigmine (DG00984): D02558<US> D03822<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09190 Not Included in Pathway or Brite
  09191 Unclassified: metabolism
   99980 Enzymes with EC numbers
    590 (BCHE)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.8  cholinesterase
     590 (BCHE)
SSDB
Motif
Pfam: COesterase AChE_tetra BD-FAE Abhydrolase_3 PBDC1
Other DBs
NCBI-GeneID: 590
NCBI-ProteinID: NP_000046
OMIM: 177400
HGNC: 983
Ensembl: ENSG00000114200
UniProt: P06276
Structure
Position
3:complement(165772904..165837423)
AA seq 602 aa
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
NT seq 1809 nt   +upstreamnt  +downstreamnt
atgcatagcaaagtcacaatcatatgcatcagatttctcttttggtttcttttgctctgc
atgcttattgggaagtcacatactgaagatgacatcataattgcaacaaagaatggaaaa
gtcagagggatgaacttgacagtttttggtggcacggtaacagcctttcttggaattccc
tatgcacagccacctcttggtagacttcgattcaaaaagccacagtctctgaccaagtgg
tctgatatttggaatgccacaaaatatgcaaattcttgctgtcagaacatagatcaaagt
tttccaggcttccatggatcagagatgtggaacccaaacactgacctcagtgaagactgt
ttatatctaaatgtatggattccagcacctaaaccaaaaaatgccactgtattgatatgg
atttatggtggtggttttcaaactggaacatcatctttacatgtttatgatggcaagttt
ctggctcgggttgaaagagttattgtagtgtcaatgaactatagggtgggtgccctagga
ttcttagctttgccaggaaatcctgaggctccagggaacatgggtttatttgatcaacag
ttggctcttcagtgggttcaaaaaaatatagcagcctttggtggaaatcctaaaagtgta
actctctttggagaaagtgcaggagcagcttcagttagcctgcatttgctttctcctgga
agccattcattgttcaccagagccattctgcaaagtggatcctttaatgctccttgggcg
gtaacatctctttatgaagctaggaacagaacgttgaacttagctaaattgactggttgc
tctagagagaatgagactgaaataatcaagtgtcttagaaataaagatccccaagaaatt
cttctgaatgaagcatttgttgtcccctatgggactcctttgtcagtaaactttggtccg
accgtggatggtgattttctcactgacatgccagacatattacttgaacttggacaattt
aaaaaaacccagattttggtgggtgttaataaagatgaagggacagcttttttagtctat
ggtgctcctggcttcagcaaagataacaatagtatcataactagaaaagaatttcaggaa
ggtttaaaaatattttttccaggagtgagtgagtttggaaaggaatccatcctttttcat
tacacagactgggtagatgatcagagacctgaaaactaccgtgaggccttgggtgatgtt
gttggggattataatttcatatgccctgccttggagttcaccaagaagttctcagaatgg
ggaaataatgcctttttctactattttgaacaccgatcctccaaacttccgtggccagaa
tggatgggagtgatgcatggctatgaaattgaatttgtctttggtttacctctggaaaga
agagataattacacaaaagccgaggaaattttgagtagatccatagtgaaacggtgggca
aattttgcaaaatatgggaatccaaatgagactcagaacaatagcacaagctggcctgtc
ttcaaaagcactgaacaaaaatatctaaccttgaatacagagtcaacaagaataatgacg
aaactacgtgctcaacaatgtcgattctggacatcattttttccaaaagtcttggaaatg
acaggaaatattgatgaagcagaatgggagtggaaagcaggattccatcgctggaacaat
tacatgatggactggaaaaatcaatttaacgattacactagcaagaaagaaagttgtgtg
ggtctctaa

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Ontology (2)   
   KEGG BRITE (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (6)   
   KEGG DRUG (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (3)   
   GenBank (10)   
   EMBL (10)   
3D Structure (89)   
   PDB (89)   
Protein domain (5)   
   Pfam (5)   
All databases (161)   

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