KEGG   Homo sapiens (human): 5917
Entry
5917              CDS       T01001                                 

Gene name
RARS1, ArgRS, DALRD1, HLD9, RARS
Definition
(RefSeq) arginyl-tRNA synthetase 1
  KO
K01887  arginyl-tRNA synthetase [EC:6.1.1.19]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H00679  Hypomyelinating leukodystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    5917 (RARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    5917 (RARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    5917 (RARS1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    5917 (RARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.19  arginine---tRNA ligase
     5917 (RARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (G)
   5917 (RARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    5917 (RARS1)
 Prokaryotic type
   Other AARSs
    5917 (RARS1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    5917 (RARS1)
SSDB
Motif
Pfam: tRNA-synt_1d DALR_1 Arg_tRNA_synt_N tRNA-synt_1e
Other DBs
NCBI-GeneID: 5917
NCBI-ProteinID: NP_002878
OMIM: 107820
HGNC: 9870
Ensembl: ENSG00000113643
Vega: OTTHUMG00000130411
Pharos: P54136(Tchem)
UniProt: P54136
Structure
PDB: 
4ZAJ 4Q2T 4Q2X 4Q2Y 4R3Z

Position
5q34
AA seq 660 aa
MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRK
SLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDYQCNSAMG
ISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLV
NGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGD
WGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGK
NPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDG
RKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIF
AAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEK
ERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTR
IRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDY
IYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM
NT seq 1983 nt   +upstreamnt  +downstreamnt
atggacgtactggtgtctgagtgctccgcgcggctgctgcagcaggaagaagagattaaa
tctctgactgctgaaattgaccggttgaaaaactgtggctgtttaggagcttctccaaat
ttggagcagttacaagaagaaaatttaaaattaaagtatcgactgaatattcttcgaaag
agtcttcaggcagaaaggaacaaaccaactaaaaatatgattaacattattagccgccta
caagaggtctttggtcatgcaattaaggctgcatatccagatttggaaaatcctcctctg
ctagtgacaccaagtcagcaggccaagtttggggactatcagtgtaatagtgctatgggt
atttctcagatgctcaaaaccaaggaacagaaagttaatccaagagaaattgctgaaaac
attaccaaacacctcccagacaatgaatgtattgaaaaagttgaaattgctggtcctggt
tttattaatgtccacttaagaaaggattttgtatcagaacaattgaccagtcttctagtg
aatggagttcaactacctgctctgggagagaataaaaaggttatagttgacttttcctcc
cctaatatagctaaagagatgcatgtaggccacctgaggtcaactatcataggagagagt
ataagccgcctctttgaatttgcagggtatgacgtgctcaggttaaatcatgtaggagac
tgggggacccagtttggcatgctcatcgctcacctgcaagacaaatttccagattatcta
acagtttcacctcctattggggatcttcaggtcttttataaggaatctaagaagaggttt
gatactgaggaggaatttaagaagcgagcatatcagtgtgtagttctgctccagggtaaa
aacccagatattacaaaagcttggaagcttatctgtgatgtctcccgccaagagttaaat
aaaatctatgatgcattggacgtctctttaatagagagaggggaatccttctatcaagat
aggatgaatgatattgtaaaggaatttgaagatagaggatttgtgcaggtggatgatggc
agaaagattgtatttgtcccagggtgttccataccattaaccatagtaaaatcagatgga
ggttatacctatgatacatctgacctggctgctattaaacaaagactatttgaggaaaaa
gcagatatgattatctatgttgtggacaatggacaatctgtgcacttccagacaatattt
gctgctgctcaaatgattggttggtatgaccctaaagtaactcgagtcttccatgctgga
tttggtgtggtgctaggggaagacaagaaaaagtttaaaacacgttcgggtgaaacagtg
cgcctcatggatcttctgggagaaggactaaaacgatccatggacaagttgaaggaaaaa
gaaagagacaaggtcttaactgcagaggaattgaatgctgctcagacatccgttgcgtat
ggctgcatcaaatatgctgacctttcccataaccggttgaatgactacatcttctccttt
gacaaaatgctagatgacagaggaaatacagctgcttacttgttgtatgccttcactaga
atcaggtctattgcacgtctggccaatattgatgaagaaatgctccaaaaagctgctcga
gaaaccaagattcttttggatcatgagaaggaatggaaactaggccggtgcattttacgg
ttccctgagattctgcaaaagattttagatgacttatttctccacactctctgtgattat
atatatgagctggcaactgctttcacagagttctatgatagctgctactgtgtggagaaa
gatagacagactggaaaaatattgaaggtgaacatgtggcgtatgctgctatgtgaagca
gtagctgctgtcatggccaaggggtttgatatcctgggaataaaacctgtccaaaggatg
taa

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
Protein domain (4)   
   Pfam (4)   
All databases (65)   

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