KEGG T01001: 596

nt06131  Apoptosis (viruses and bacteria)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06227  NR signaling
nt06231  Apoptosis
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
nt06270  Breast cancer
nt06323  KISS1-GnRH-LH/FSH-E2 signaling

Element

N00098

Intrinsic apoptotic pathway

N00100

BCL2-overexpression to intrinsic apoptotic pathway

N00262

EBV EBNA3C to intrinsic apoptotic pathway

N00286

Nuclear-initiated estrogen signaling pathway

N00451

HIV Tat to intrinsic apoptotic pathway

N00452

HIV Nef to intrinsic apoptotic pathway

N00453

HIV Vpr to intrinsic apoptotic pathway

N00474

EBV BHRF1 to intrinsic apoptotic pathway

N00475

EBV BHRF1 to intrinsic apoptotic pathway

N00478

EBV BARF1 to intrinsic apoptotic pathway

N00585

HSV US3 to intrinsic apoptotic pathway

Disease

H00005

Chronic lymphocytic leukemia

H00013

Small cell lung cancer

H00028

Choriocarcinoma

H00030

Cervical cancer

H00041

Kaposi sarcoma

H00054

Nasopharyngeal cancer

H01613

Follicular lymphoma

Drug target

Obatoclax mesylate:

D08954

Oblimersen (DG00728):

D05216 D08290

Venetoclax:

D10679

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    596 (BCL2)
09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    596 (BCL2)
   04630 Jak-STAT signaling pathway
    596 (BCL2)
   04064 NF-kappa B signaling pathway
    596 (BCL2)
   04066 HIF-1 signaling pathway
    596 (BCL2)
   04071 Sphingolipid signaling pathway
    596 (BCL2)
   04151 PI3K-Akt signaling pathway
    596 (BCL2)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    596 (BCL2)
  09143 Cell growth and death
   04210 Apoptosis
    596 (BCL2)
   04215 Apoptosis - multiple species
    596 (BCL2)
   04217 Necroptosis
    596 (BCL2)
   04115 p53 signaling pathway
    596 (BCL2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    596 (BCL2)
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    596 (BCL2)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    596 (BCL2)
   04928 Parathyroid hormone synthesis, secretion and action
    596 (BCL2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    596 (BCL2)
  09156 Nervous system
   04725 Cholinergic synapse
    596 (BCL2)
   04722 Neurotrophin signaling pathway
    596 (BCL2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    596 (BCL2)
   05206 MicroRNAs in cancer
    596 (BCL2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    596 (BCL2)
   05226 Gastric cancer
    596 (BCL2)
   05215 Prostate cancer
    596 (BCL2)
   05222 Small cell lung cancer
    596 (BCL2)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis (ALS)
    596 (BCL2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    596 (BCL2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    596 (BCL2)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    596 (BCL2)
   05152 Tuberculosis
    596 (BCL2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    596 (BCL2)
   05162 Measles
    596 (BCL2)
   05161 Hepatitis B
    596 (BCL2)
   05168 Herpes simplex virus 1 infection
    596 (BCL2)
   05169 Epstein-Barr virus infection
    596 (BCL2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    596 (BCL2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    596 (BCL2)
   01524 Platinum drug resistance
    596 (BCL2)
   01522 Endocrine resistance
    596 (BCL2)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    596 (BCL2)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     596 (BCL2)

SSDB

Motif

Pfam:

Bcl-2 BH4 Bcl-2_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P10415(Tclin)

UniProt:

P10415 A0A024R2B3

Structure

PDB:

6GL8 6QGG 6O0K 6O0M 5VAU 6O0P 6QGK 5VAY 6QGJ 6QG8 4LXD 6O0O 6QGH 5VAX 4LVT 4MAN 5JSN 5FCG 4IEH 2W3L 6O0L 5AGX 4AQ3 5AGW 2XA0 2O21 2O22 2O2F 1YSW 1GJH 1G5M

Position

18q21.33

AA seq 239 aa
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

NT seq 720 nt +upstreamnt +downstreamnt
atggcgcacgctgggagaacagggtacgataaccgggagatagtgatgaagtacatccat
tataagctgtcgcagaggggctacgagtgggatgcgggagatgtgggcgccgcgcccccg
ggggccgcccccgcaccgggcatcttctcctcccagcccgggcacacgccccatccagcc
gcatcccgggacccggtcgccaggacctcgccgctgcagaccccggctgcccccggcgcc
gccgcggggcctgcgctcagcccggtgccacctgtggtccacctgaccctccgccaggcc
ggcgacgacttctcccgccgctaccgccgcgacttcgccgagatgtccagccagctgcac
ctgacgcccttcaccgcgcggggacgctttgccacggtggtggaggagctcttcagggac
ggggtgaactgggggaggattgtggccttctttgagttcggtggggtcatgtgtgtggag
agcgtcaaccgggagatgtcgcccctggtggacaacatcgccctgtggatgactgagtac
ctgaaccggcacctgcacacctggatccaggataacggaggctgggatgcctttgtggaa
ctgtacggccccagcatgcggcctctgtttgatttctcctggctgtctctgaagactctg
ctcagtttggccctggtgggagcttgcatcaccctgggtgcctatctgggccacaagtga

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