KEGG   Homo sapiens (human): 5972
Entry
5972              CDS       T01001                                 
Symbol
REN, ADTKD4, HNFJ2, RTD
Name
(RefSeq) renin
  KO
K01380  renin [EC:3.4.23.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
hsa04924  Renin secretion
hsa05415  Diabetic cardiomyopathy
Disease
H00541  Autosomal dominant tubulointerstitial kidney disease
H00575  Renal tubular dysgenesis
H02011  Familial juvenile hyperuricemic nephropathy
Drug target
Aliskiren (DG00352): D03208 D06412<JP/US>
Ditekiren: D03741
Enalkiren: D03738
Remikiren: D09038
Terlakiren: D03743
Zankiren hydrochloride: D03745
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    5972 (REN)
   04614 Renin-angiotensin system
    5972 (REN)
 09160 Human Diseases
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    5972 (REN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5972 (REN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.15  renin
     5972 (REN)
Peptidases and inhibitors [BR:hsa01002]
 Aspartic peptidases
  Family A1: pepsin family
   5972 (REN)
SSDB
Motif
Pfam: Asp TAXi_N A1_Propeptide TAXi_C Asp_protease_2 DUF6086
Other DBs
NCBI-GeneID: 5972
NCBI-ProteinID: NP_000528
OMIM: 179820
HGNC: 9958
Ensembl: ENSG00000143839
Pharos: P00797(Tclin)
UniProt: P00797
Structure
Position
1:complement(204154819..204166337)
AA seq 406 aa
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
NT seq 1221 nt   +upstreamnt  +downstreamnt
atggatggatggagaaggatgcctcgctggggactgctgctgctgctctggggctcctgt
acctttggtctcccgacagacaccaccacctttaaacggatcttcctcaagagaatgccc
tcaatccgagaaagcctgaaggaacgaggtgtggacatggccaggcttggtcccgagtgg
agccaacccatgaagaggctgacacttggcaacaccacctcctccgtgatcctcaccaac
tacatggacacccagtactatggcgagattggcatcggcaccccaccccagaccttcaaa
gtcgtctttgacactggttcgtccaatgtttgggtgccctcctccaagtgcagccgtctc
tacactgcctgtgtgtatcacaagctcttcgatgcttcggattcctccagctacaagcac
aatggaacagaactcaccctccgctattcaacagggacagtcagtggctttctcagccag
gacatcatcaccgtgggtggaatcacggtgacacagatgtttggagaggtcacggagatg
cccgccttacccttcatgctggccgagtttgatggggttgtgggcatgggcttcattgaa
caggccattggcagggtcacccctatcttcgacaacatcatctcccaaggggtgctaaaa
gaggacgtcttctctttctactacaacagagattccgagaattcccaatcgctgggagga
cagattgtgctgggaggcagcgacccccagcattacgaagggaatttccactatatcaac
ctcatcaagactggtgtctggcagattcaaatgaagggggtgtctgtggggtcatccacc
ttgctctgtgaagacggctgcctggcattggtagacaccggtgcatcctacatctcaggt
tctaccagctccatagagaagctcatggaggccttgggagccaagaagaggctgtttgat
tatgtcgtgaagtgtaacgagggccctacactccccgacatctctttccacctgggaggc
aaagaatacacgctcaccagcgcggactatgtatttcaggaatcctacagtagtaaaaag
ctgtgcacactggccatccacgccatggatatcccgccacccactggacccacctgggcc
ctgggggccaccttcatccgaaagttctacacagagtttgatcggcgtaacaaccgcatt
ggcttcgccttggcccgctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Drug (7)   
   KEGG DRUG (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
   PHAROS (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
3D Structure (88)   
   PDB (88)   
Protein domain (6)   
   Pfam (6)   
All databases (163)   

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