KEGG   Homo sapiens (human): 5972
Entry
5972              CDS       T01001                                 

Gene name
REN, HNFJ2
Definition
(RefSeq) renin
  KO
K01380  renin [EC:3.4.23.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
hsa04924  Renin secretion
Disease
H00541  Autosomal dominant tubulointerstitial kidney disease
H00575  Renal tubular dysgenesis
H02011  Familial juvenile hyperuricemic nephropathy
Drug target
Aliskiren (DG00352): D03208 D06412<JP/US>
Ditekiren: D03741
Enalkiren: D03738
Remikiren: D09038
Terlakiren: D03743
Zankiren hydrochloride: D03745
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    5972 (REN)
   04614 Renin-angiotensin system
    5972 (REN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.15  renin
     5972 (REN)
Peptidases and inhibitors [BR:hsa01002]
 Aspartic peptidases
  Family A1: pepsin family
   5972 (REN)
SSDB
Motif
Pfam: Asp TAXi_N TAXi_C A1_Propeptide Asp_protease_2
Other DBs
NCBI-GeneID: 5972
NCBI-ProteinID: NP_000528
OMIM: 179820
HGNC: 9958
Ensembl: ENSG00000143839
Vega: OTTHUMG00000036059
Pharos: P00797(Tclin)
UniProt: P00797
Structure
PDB: 

Position
1q32.1
AA seq 406 aa
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
NT seq 1221 nt   +upstreamnt  +downstreamnt
atggatggatggagaaggatgcctcgctggggactgctgctgctgctctggggctcctgt
acctttggtctcccgacagacaccaccacctttaaacggatcttcctcaagagaatgccc
tcaatccgagaaagcctgaaggaacgaggtgtggacatggccaggcttggtcccgagtgg
agccaacccatgaagaggctgacacttggcaacaccacctcctccgtgatcctcaccaac
tacatggacacccagtactatggcgagattggcatcggcaccccaccccagaccttcaaa
gtcgtctttgacactggttcgtccaatgtttgggtgccctcctccaagtgcagccgtctc
tacactgcctgtgtgtatcacaagctcttcgatgcttcggattcctccagctacaagcac
aatggaacagaactcaccctccgctattcaacagggacagtcagtggctttctcagccag
gacatcatcaccgtgggtggaatcacggtgacacagatgtttggagaggtcacggagatg
cccgccttacccttcatgctggccgagtttgatggggttgtgggcatgggcttcattgaa
caggccattggcagggtcacccctatcttcgacaacatcatctcccaaggggtgctaaaa
gaggacgtcttctctttctactacaacagagattccgagaattcccaatcgctgggagga
cagattgtgctgggaggcagcgacccccagcattacgaagggaatttccactatatcaac
ctcatcaagactggtgtctggcagattcaaatgaagggggtgtctgtggggtcatccacc
ttgctctgtgaagacggctgcctggcattggtagacaccggtgcatcctacatctcaggt
tctaccagctccatagagaagctcatggaggccttgggagccaagaagaggctgtttgat
tatgtcgtgaagtgtaacgagggccctacactccccgacatctctttccacctgggaggc
aaagaatacacgctcaccagcgcggactatgtatttcaggaatcctacagtagtaaaaag
ctgtgcacactggccatccacgccatggatatcccgccacccactggacccacctgggcc
ctgggggccaccttcatccgaaagttctacacagagtttgatcggcgtaacaaccgcatt
ggcttcgccttggcccgctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Drug (7)   
   KEGG DRUG (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
Protein domain (5)   
   Pfam (5)   
All databases (74)   

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