KEGG   Homo sapiens (human): 5976
Entry
5976              CDS       T01001                                 
Symbol
UPF1, HUPF1, NORF1, RENT1, UTF, pNORF1, smg-2
Name
(RefSeq) UPF1 RNA helicase and ATPase
  KO
K14326  regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa03015  mRNA surveillance pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03013 Nucleocytoplasmic transport
    5976 (UPF1)
   03015 mRNA surveillance pathway
    5976 (UPF1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5976 (UPF1)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     5976 (UPF1)
    5.6.2.5  RNA 5'-3' helicase
     5976 (UPF1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Surveillance factors
    Surveillance complex
     5976 (UPF1)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     5976 (UPF1)
SSDB
Motif
Pfam: UPF1_Zn_bind AAA_12 AAA_11 UPF1_1B_dom AAA_30 AAA_19 ResIII SLFN-g3_helicase NPHP3_N ATPase nSTAND3 Helicase_RecD DEAD AAA_16 UvrD-helicase SRP54 UvrD_C_2 AAA_22
Other DBs
NCBI-GeneID: 5976
NCBI-ProteinID: NP_001284478
OMIM: 601430
HGNC: 9962
Ensembl: ENSG00000005007
UniProt: Q92900 B3KY55
Structure
Position
19:18831959..18868230
AA seq 1129 aa
MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
GPGGAGAGAAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII
WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNF
QVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLP
DLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQ
LTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSS
ADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVP
VVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALS
AFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTE
AANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAF
QGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLL
NYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAIIPGSVYDR
SSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRG
TPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQ
PGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
NT seq 3390 nt   +upstreamnt  +downstreamnt
atgagcgtggaggcgtacgggcccagctcgcagactctcactttcctggacacggaggag
gccgagctgcttggcgccgacacacagggctccgagttcgagttcaccgactttactctt
cctagccagacgcagacgccccccggcggccccggcggcccgggcggtggcggcgcggga
ggcccgggcggcgcgggcgcgggcgctgcggcgggacagctcgacgcgcaggttgggccc
gaaggcatcctgcagaacggggctgtggacgacagtgtagccaagaccagccagttgttg
gctgagttgaacttcgaggaagatgaagaagacacctattacacgaaggacctccccata
cacgcctgcagttactgtggaatacacgatcctgcctgcgtggtttactgtaataccagc
aagaagtggttctgcaacggacgtggaaatacttctggcagccacattgtaaatcacctt
gtgagggcaaaatgcaaagaggtgaccctgcacaaggacgggcccctgggggagacagtc
ctggagtgctacaactgcggctgtcgcaacgtcttcctcctcggcttcatcccggccaaa
gctgactcagtggtggtgctgctgtgcaggcagccctgtgccagccagagcagcctcaag
gacatcaactgggacagctcgcagtggcagccgctgatccaggaccgctgcttcctgtcc
tggctggtcaagatcccctccgagcaggagcagctgcgggcacgccagatcacggcacag
cagatcaacaagctggaggagctgtggaaggaaaacccttctgccacgctggaggacctg
gagaagccgggggtggacgaggagccgcagcatgtcctcctgcggtacgaggacgcctac
cagtaccagaacatattcgggcccctggtcaagctggaggccgactacgacaagaagctg
aaggagtcccagactcaagataacatcactgtcaggtgggacctgggccttaacaagaag
agaatcgcctacttcactttgcccaagactgactctggtaatgaggatttagtcataatt
tggttaagagacatgcggctcatgcagggggatgagatatgcctgcggtacaaaggggac
cttgcgcccctgtggaaagggatcggccacgtcatcaaggtccctgataattatggcgat
gagatcgccattgagctgcggagcagcgtgggtgcacctgtggaggtgactcacaacttc
caggtggattttgtgtggaagtcgacctcctttgacaggatgcagagcgcattgaaaacg
tttgccgtggatgagacctcggtgtctggctacatctaccacaagctgttgggccacgag
gtggaggacgtaatcatcaagtgccagctgcccaagcgcttcacggcgcagggcctcccc
gacctcaaccactcccaggtttatgccgtgaagactgtgctgcaaagaccactgagcctg
atccagggcccgccaggcacggggaagacggtgacgtcggccaccatcgtctaccacctg
gcccggcaaggcaacgggccggtgctggtgtgtgctccgagcaacatcgccgtggaccag
ctaacggagaagatccaccagacggggctaaaggtcgtgcgcctctgcgccaagagccgt
gaggccatcgactccccggtgtcttttctggccctgcacaaccagatcaggaacatggac
agcatgcctgagctgcagaagctgcagcagctgaaagacgagactggggagctgtcgtct
gccgacgagaagcggtaccgggccttgaagcgcaccgcagagagagagctgctgatgaac
gcagatgtcatctgctgcacatgtgtgggcgccggtgacccgaggctggccaagatgcag
ttccgctccattttaatcgacgaaagcacccaggccaccgagccggagtgcatggttccc
gtggtcctcggggccaagcagctgatccttgtaggcgaccactgccagctgggcccagtg
gtgatgtgcaagaaggcggccaaggccgggctgtcacagtcgctcttcgagcgcctggtg
gtgctgggcatccggcccatccgcctgcaggtccagtaccggatgcaccctgcactcagc
gccttcccatccaacatcttctacgagggctccctccagaatggtgtcactgcagcggat
cgtgtgaagaagggatttgacttccagtggccccaacccgataaaccgatgttcttctac
gtgacccagggccaagaggagattgccagctcgggcacctcctacctgaacaggaccgag
gctgcgaacgtggagaagatcaccacgaagttgctgaaggcaggcgccaagccggaccag
attggcatcatcacgccctacgagggccagcgctcctacctggtgcagtacatgcagttc
agcggctccctgcacaccaagctctaccaggaggtggagatcgccagtgtggacgccttt
cagggacgcgagaaggacttcatcatcctgtcctgtgtgcgggccaacgagcaccaaggc
attggctttttaaatgaccccaggcgtctgaacgtggccctgaccagagcaaggtatggc
gtcatcattgtgggcaacccgaaggcactatcaaagcagccgctctggaaccacctgctg
aactactataaggagcagaaggtgctggtggaggggccgctcaacaacctgcgtgagagc
ctcatgcagttcagcaagccacggaagctggtcaacactatcaacccgggagcccgcttc
atgaccacagccatgtatgatgcccgggaggccatcatcccaggctccgtctatgatcgg
agcagccagggccggccttccagcatgtacttccagacccatgaccagattggcatgatc
agtgccggccctagccacgtggctgccatgaacattcccatccccttcaacctggtcatg
ccacccatgccaccgcctggctattttggacaagccaacgggcctgctgcagggcgaggc
accccgaaaggcaagactggtcgtgggggacgccagaagaaccgctttgggcttcctgga
cccagccagactaacctccccaacagccaagccagccaggatgtggcgtcacagcccttc
tctcagggcgccctgacgcagggctacatctccatgagccagccttcccagatgagccag
cccggcctctcccagccggagctgtcccaggacagttaccttggtgacgagtttaaatca
caaatcgacgtggcgctctcacaggactccacgtaccagggagagcgggcttaccagcat
ggcggggtgacggggctgtcccagtattaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (32)   
   RefGene (24)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (54)   
   RefSeq(nuc) (8)   
   GenBank (23)   
   EMBL (23)   
3D Structure (11)   
   PDB (11)   
Protein domain (18)   
   Pfam (18)   
All databases (127)   

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