KEGG   Homo sapiens (human): 5976
Entry
5976              CDS       T01001                                 
Symbol
UPF1, HUPF1, NORF1, RENT1, UTF, pNORF1, smg-2
Name
(RefSeq) UPF1 RNA helicase and ATPase
  KO
K14326  regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa03015  mRNA surveillance pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03013 Nucleocytoplasmic transport
    5976 (UPF1)
   03015 mRNA surveillance pathway
    5976 (UPF1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5976 (UPF1)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     5976 (UPF1)
    5.6.2.5  RNA 5'-3' helicase
     5976 (UPF1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Surveillance factors
    Surveillance complex
     5976 (UPF1)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     5976 (UPF1)
SSDB
Motif
Pfam: UPF1_Zn_bind AAA_12 AAA_11 UPF1_1B_dom AAA_30 AAA_19 ResIII SLFN-g3_helicase ATPase nSTAND3 Helicase_RecD DEAD AAA_16 UvrD-helicase SRP54 UvrD_C_2 AAA_22
Other DBs
NCBI-GeneID: 5976
NCBI-ProteinID: NP_001284478
OMIM: 601430
HGNC: 9962
Ensembl: ENSG00000005007
UniProt: Q92900 B3KY55
Structure
Position
19:18831959..18868230
AA seq 1129 aa
MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
GPGGAGAGAAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII
WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNF
QVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLP
DLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQ
LTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSS
ADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVP
VVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALS
AFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTE
AANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAF
QGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLL
NYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAIIPGSVYDR
SSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRG
TPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQ
PGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
NT seq 3390 nt   +upstreamnt  +downstreamnt
atgagcgtggaggcgtacgggcccagctcgcagactctcactttcctggacacggaggag
gccgagctgcttggcgccgacacacagggctccgagttcgagttcaccgactttactctt
cctagccagacgcagacgccccccggcggccccggcggcccgggcggtggcggcgcggga
ggcccgggcggcgcgggcgcgggcgctgcggcgggacagctcgacgcgcaggttgggccc
gaaggcatcctgcagaacggggctgtggacgacagtgtagccaagaccagccagttgttg
gctgagttgaacttcgaggaagatgaagaagacacctattacacgaaggacctccccata
cacgcctgcagttactgtggaatacacgatcctgcctgcgtggtttactgtaataccagc
aagaagtggttctgcaacggacgtggaaatacttctggcagccacattgtaaatcacctt
gtgagggcaaaatgcaaagaggtgaccctgcacaaggacgggcccctgggggagacagtc
ctggagtgctacaactgcggctgtcgcaacgtcttcctcctcggcttcatcccggccaaa
gctgactcagtggtggtgctgctgtgcaggcagccctgtgccagccagagcagcctcaag
gacatcaactgggacagctcgcagtggcagccgctgatccaggaccgctgcttcctgtcc
tggctggtcaagatcccctccgagcaggagcagctgcgggcacgccagatcacggcacag
cagatcaacaagctggaggagctgtggaaggaaaacccttctgccacgctggaggacctg
gagaagccgggggtggacgaggagccgcagcatgtcctcctgcggtacgaggacgcctac
cagtaccagaacatattcgggcccctggtcaagctggaggccgactacgacaagaagctg
aaggagtcccagactcaagataacatcactgtcaggtgggacctgggccttaacaagaag
agaatcgcctacttcactttgcccaagactgactctggtaatgaggatttagtcataatt
tggttaagagacatgcggctcatgcagggggatgagatatgcctgcggtacaaaggggac
cttgcgcccctgtggaaagggatcggccacgtcatcaaggtccctgataattatggcgat
gagatcgccattgagctgcggagcagcgtgggtgcacctgtggaggtgactcacaacttc
caggtggattttgtgtggaagtcgacctcctttgacaggatgcagagcgcattgaaaacg
tttgccgtggatgagacctcggtgtctggctacatctaccacaagctgttgggccacgag
gtggaggacgtaatcatcaagtgccagctgcccaagcgcttcacggcgcagggcctcccc
gacctcaaccactcccaggtttatgccgtgaagactgtgctgcaaagaccactgagcctg
atccagggcccgccaggcacggggaagacggtgacgtcggccaccatcgtctaccacctg
gcccggcaaggcaacgggccggtgctggtgtgtgctccgagcaacatcgccgtggaccag
ctaacggagaagatccaccagacggggctaaaggtcgtgcgcctctgcgccaagagccgt
gaggccatcgactccccggtgtcttttctggccctgcacaaccagatcaggaacatggac
agcatgcctgagctgcagaagctgcagcagctgaaagacgagactggggagctgtcgtct
gccgacgagaagcggtaccgggccttgaagcgcaccgcagagagagagctgctgatgaac
gcagatgtcatctgctgcacatgtgtgggcgccggtgacccgaggctggccaagatgcag
ttccgctccattttaatcgacgaaagcacccaggccaccgagccggagtgcatggttccc
gtggtcctcggggccaagcagctgatccttgtaggcgaccactgccagctgggcccagtg
gtgatgtgcaagaaggcggccaaggccgggctgtcacagtcgctcttcgagcgcctggtg
gtgctgggcatccggcccatccgcctgcaggtccagtaccggatgcaccctgcactcagc
gccttcccatccaacatcttctacgagggctccctccagaatggtgtcactgcagcggat
cgtgtgaagaagggatttgacttccagtggccccaacccgataaaccgatgttcttctac
gtgacccagggccaagaggagattgccagctcgggcacctcctacctgaacaggaccgag
gctgcgaacgtggagaagatcaccacgaagttgctgaaggcaggcgccaagccggaccag
attggcatcatcacgccctacgagggccagcgctcctacctggtgcagtacatgcagttc
agcggctccctgcacaccaagctctaccaggaggtggagatcgccagtgtggacgccttt
cagggacgcgagaaggacttcatcatcctgtcctgtgtgcgggccaacgagcaccaaggc
attggctttttaaatgaccccaggcgtctgaacgtggccctgaccagagcaaggtatggc
gtcatcattgtgggcaacccgaaggcactatcaaagcagccgctctggaaccacctgctg
aactactataaggagcagaaggtgctggtggaggggccgctcaacaacctgcgtgagagc
ctcatgcagttcagcaagccacggaagctggtcaacactatcaacccgggagcccgcttc
atgaccacagccatgtatgatgcccgggaggccatcatcccaggctccgtctatgatcgg
agcagccagggccggccttccagcatgtacttccagacccatgaccagattggcatgatc
agtgccggccctagccacgtggctgccatgaacattcccatccccttcaacctggtcatg
ccacccatgccaccgcctggctattttggacaagccaacgggcctgctgcagggcgaggc
accccgaaaggcaagactggtcgtgggggacgccagaagaaccgctttgggcttcctgga
cccagccagactaacctccccaacagccaagccagccaggatgtggcgtcacagcccttc
tctcagggcgccctgacgcagggctacatctccatgagccagccttcccagatgagccag
cccggcctctcccagccggagctgtcccaggacagttaccttggtgacgagtttaaatca
caaatcgacgtggcgctctcacaggactccacgtaccagggagagcgggcttaccagcat
ggcggggtgacggggctgtcccagtattaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (24)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (54)   
   RefSeq(nuc) (8)   
   GenBank (23)   
   EMBL (23)   
3D Structure (10)   
   PDB (10)   
Protein domain (17)   
   Pfam (17)   
All databases (134)   

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