KEGG   Homo sapiens (human): 5978
Entry
5978              CDS       T01001                                 

Gene name
REST, DFNA27, GINGF5, HGF5, NRSF, WT6, XBR
Definition
(RefSeq) RE1 silencing transcription factor
  KO
K09222  RE1-silencing transcription factor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa05016  Huntington disease
Network
nt06440  Transcription
nt06461  Huntington disease
  Element
N00980  Mutation-caused aberrant Htt to REST-mediated transcriptional repression
Disease
H00604  Deafness, autosomal dominant
H01250  Hereditary gingival fibromatosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    5978 (REST)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    5978 (REST)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5978 (REST)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 others
    5978 (REST)
SSDB
Motif
Pfam: zf-H2C2_2 zf-H2C2_5 zf-C2H2 zf-C2H2_4
Other DBs
NCBI-GeneID: 5978
NCBI-ProteinID: NP_001180437
OMIM: 600571
HGNC: 9966
Ensembl: ENSG00000084093
Vega: OTTHUMG00000128770
Pharos: Q13127(Tbio)
UniProt: Q13127
Position
4q12
AA seq 1097 aa
MATQVMGQSSGGGGLFTSSGNIGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNG
SCCDYLVGEERQMAELMPVGDNNFSDSEEGEGLEESADIKGEPHGLENMELRSLELSVVE
PQPVFEASGAPDIYSSNKDLPPETPGAEDKGKSSKTKPFRCKPCQYEAESEEQFVHHIRV
HSAKKFFVEESAEKQAKARESGSSTAEEGDFSKGPIRCDRCGYNTNRYDHYTAHLKHHTR
AGDNERVYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCGKCNYFSDRKNNYVQHVRTHTG
ERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCSYVASNQHEVTRHARQVHNGPKP
LNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPNKTM
DVSKVKLKKTKKREADLPDNITNEKTEIEQTKIKGDVAGKKNEKSVKAEKRDVSKEKKPS
NNVSVIQVTTRTRKSVTEVKEMDVHTGSNSEKFSKTKKSKRKLEVDSHSLHGPVNDEESS
TKKKKKVESKSKNNSQEVPKGDSKVEENKKQNTCMKKSTKKKTLKNKSSKKSSKPPQKEP
VEKGSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQMEGAQIRPAPDEPVQMEVVQEG
PAQKELLPPVEPAQMVGAQIVLAHMELPPPMETAQTEVAQMGPAPMEPAQMEVAQVESAP
MQVVQKEPVQMELSPPMEVVQKEPVQIELSPPMEVVQKEPVKIELSPPIEVVQKEPVQME
LSPPMGVVQKEPAQREPPPPREPPLHMEPISKKPPLRKDKKEKSNMQSERARKEQVLIEV
GLVPVKDSWLLKESVSTEDLSPPSPPLPKENLREEASGDQKLLNTGEGNKEAPLQKVGAE
EADESLPGLAANINESTHISSSGQNLNTPEGETLNGKHQTDSIVCEMKMDTDQNTRENLT
GINSTVEEPVSPMLPPSAVEEREAVSKTALASPPATMAANESQEIDEDEGIHSHEGSDLS
DNMSEGSDDSGLHGARPVPQESSRKNAKEALAVKAAKGDFVCIFCDRSFRKGKDYSKHLN
RHLVNVYYLEEAAQGQE
NT seq 3294 nt   +upstreamnt  +downstreamnt
atggccacccaggtaatggggcagtcttctggaggaggagggctgtttaccagcagtggc
aacattggaatggccctgcctaacgacatgtatgacttgcatgacctttccaaagctgaa
ctggccgcacctcagcttattatgctggcaaatgtggccttaactggggaagtaaatggc
agctgctgtgattacctggtcggtgaagaaagacagatggcagaactgatgccggttggg
gataacaacttttcagatagtgaagaaggagaaggacttgaagagtctgctgatataaaa
ggtgaacctcatggactggaaaacatggaactgagaagtttggaactcagcgtcgtagaa
cctcagcctgtatttgaggcatcaggtgctccagatatttacagttcaaataaagatctt
ccccctgaaacacctggagcggaggacaaaggcaagagctcgaagaccaaaccctttcgc
tgtaagccatgccaatatgaagcagaatctgaagaacagtttgtgcatcacatcagagtt
cacagtgctaagaaattttttgtggaagagagtgcagagaagcaggcaaaagccagggaa
tctggctcttccactgcagaagagggagatttctccaagggccccattcgctgtgaccgc
tgcggctacaatactaatcgatatgatcactatacagcacacctgaaacaccacaccaga
gctggggataatgagcgagtctacaagtgtatcatttgcacatacacaacagtgagcgag
tatcactggaggaaacatttaagaaaccattttccaaggaaagtatacacatgtggaaaa
tgcaactatttttcagacagaaaaaacaattatgttcagcatgttagaactcatacagga
gaacgcccatataaatgtgaactttgtccttactcaagttctcagaagactcatctaact
agacatatgcgtactcattcaggtgagaagccatttaaatgtgatcagtgcagttatgtg
gcctctaatcaacatgaagtaacccgccatgcaagacaggttcacaatgggcctaaacct
cttaattgcccacactgtgattacaaaacagcagatagaagcaacttcaaaaaacatgta
gagctacatgtgaacccacggcagttcaattgccctgtatgtgactatgcagcttccaag
aagtgtaatctacagtatcacttcaaatctaagcatcctacttgtcctaataaaacaatg
gatgtctcaaaagtgaaactaaagaaaaccaaaaaacgagaggctgacttgcctgataat
attaccaatgaaaaaacagaaatagaacaaacaaaaataaaaggggatgtggctggaaag
aaaaatgaaaagtccgtcaaagcagagaaaagagatgtctcaaaagagaaaaagccttct
aataatgtgtcagtgatccaggtgactaccagaactcgaaaatcagtaacagaggtgaaa
gagatggatgtgcatacaggaagcaattcagaaaaattcagtaaaactaagaaaagcaaa
aggaagctggaagttgacagccattctttacatggtcctgtgaatgatgaggaatcttca
acaaaaaagaaaaagaaggtagaaagcaaatccaaaaataatagtcaggaagtgccaaag
ggtgacagcaaagtggaggagaataaaaagcaaaatacttgcatgaaaaaaagtacaaag
aagaaaactctgaaaaataaatcaagtaagaaaagcagtaagcctcctcagaaggaacct
gttgagaagggatctgctcagatggaccctcctcagatggggcctgctcccacagaggcg
gttcagaaggggcccgttcaggtggagccgccacctcccatggagcatgctcagatggag
ggtgcccagatacggcctgctcctgacgagcctgttcagatggaggtggttcaggagggg
cctgctcagaaggagctgctgcctcccgtggagcctgctcagatggtgggtgcccaaatt
gtacttgctcacatggagctgcctcctcccatggagactgctcagacggaggttgcccaa
atggggcctgctcccatggaacctgctcagatggaggttgcccaggtagaatctgctccc
atgcaggtggtccagaaggagcctgttcagatggagctgtctcctcccatggaggtggtc
cagaaggagcctgttcagatagagctgtctcctcccatggaggtggtccagaaggaacct
gttaagatagagctgtctcctcccatagaggtggtccagaaggagcctgttcagatggag
ttgtctcctcccatgggggtggttcagaaggagcctgctcagagggagccacctcctccc
agagagcctccccttcacatggagccaatttccaaaaagcctcctctccgaaaagataaa
aaggaaaagtctaacatgcagagtgaaagggcacggaaggagcaagtccttattgaagtt
ggcttagtgcctgttaaagatagctggcttctaaaggaaagtgtaagcacagaggatctc
tcaccaccatcaccaccactgccaaaggaaaatttaagagaagaggcatcaggagaccaa
aaattactcaacacaggtgaaggaaataaagaagcccctcttcagaaagtaggagcagaa
gaggcagatgagagcctacctggtcttgctgctaatatcaacgaatctacccatatttca
tcctctggacaaaacttgaatacgccagagggtgaaactttaaatggtaaacatcagact
gacagtatagtttgtgaaatgaaaatggacactgatcagaacacaagagagaatctcact
ggtataaattcaacagttgaagaaccagtttcaccaatgcttcccccttcagcagtagaa
gaacgtgaagcagtgtccaaaactgcactggcatcacctcctgctacaatggcagcaaat
gagtctcaggaaattgatgaagatgaaggcatccacagccatgaaggaagtgacctaagt
gacaacatgtcagagggtagtgatgattctggattgcatggggctcggccagttccacaa
gaatctagcagaaaaaatgcaaaggaagccttggcagtcaaagcggctaagggagatttt
gtttgtatcttctgtgatcgttctttcagaaagggaaaagattacagcaaacacctcaat
cgccatttggttaatgtgtactatcttgaagaagcagctcaagggcaggagtaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (1)   
   KEGG NETWORK (1)   
Disease (6)   
   KEGG DISEASE (2)   
   OMIM (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (48)   
   KEGG ORTHOLOGY (1)   
   RefGene (39)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (106)   
   RefSeq(nuc) (4)   
   GenBank (51)   
   EMBL (51)   
Protein domain (4)   
   Pfam (4)   
All databases (176)   

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