KEGG T01001: 598

nt06131  Apoptosis (viruses and bacteria)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06219  JAK-STAT signaling
nt06231  Apoptosis
nt06240  Transcription
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06414  Apoptosis
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis

Element

N00055

BCR-ABL fusion kinase to Jak-STAT signaling pathway

N00098

Intrinsic apoptotic pathway

N00123

Amplified REL to transcription

N00451

HIV Tat to intrinsic apoptotic pathway

N01051

Mutation-inactivated DJ1 to intrinsic apoptotic pathway

Drug target

Navitoclax:

D09935

Navitoclax dihydrochloride:

D09936

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    598 (BCL2L1)
   04630 JAK-STAT signaling pathway
    598 (BCL2L1)
   04064 NF-kappa B signaling pathway
    598 (BCL2L1)
   04151 PI3K-Akt signaling pathway
    598 (BCL2L1)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    598 (BCL2L1)
   04137 Mitophagy - animal
    598 (BCL2L1)
  09143 Cell growth and death
   04210 Apoptosis
    598 (BCL2L1)
   04215 Apoptosis - multiple species
    598 (BCL2L1)
   04115 p53 signaling pathway
    598 (BCL2L1)
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    598 (BCL2L1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    598 (BCL2L1)
   05202 Transcriptional misregulation in cancer
    598 (BCL2L1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    598 (BCL2L1)
   05225 Hepatocellular carcinoma
    598 (BCL2L1)
   05220 Chronic myeloid leukemia
    598 (BCL2L1)
   05222 Small cell lung cancer
    598 (BCL2L1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    598 (BCL2L1)
   05014 Amyotrophic lateral sclerosis
    598 (BCL2L1)
   05022 Pathways of neurodegeneration - multiple diseases
    598 (BCL2L1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    598 (BCL2L1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    598 (BCL2L1)
   05170 Human immunodeficiency virus 1 infection
    598 (BCL2L1)
   05162 Measles
    598 (BCL2L1)
   05168 Herpes simplex virus 1 infection
    598 (BCL2L1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    598 (BCL2L1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    598 (BCL2L1)
   01524 Platinum drug resistance
    598 (BCL2L1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    598 (BCL2L1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    598 (BCL2L1)
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    598 (BCL2L1)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     598 (BCL2L1)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    598 (BCL2L1)
Transporters [BR:hsa02000]
Other transporters
  Pores ion channels [TC:1]
   598 (BCL2L1)

SSDB

Motif

Pfam:

Bcl-2 BH4 Bcl-2_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q07817(Tchem)

UniProt:

Q07817 A0A0S2Z3C5

Structure

PDB:

3SP7 4QVF 4A1U 3SPF 5FMK 4BPK 3FDL 4TUH 2YQ6 2YQ7 5VX3 3R85 1R2D 3INQ 1R2I 3QKD 3ZLR 4QVE 4C52 4EHR 4Z9V 4QVX 1R2E 5B1Z 6DCO 2YXJ 1R2H 1MAZ 2YJ1 3FDM 3ZLN 4C5D 3IO8 6RNU 5FMJ 6DCN 3WIZ 3ZK6 4A1W 2P1L 3ZLO 3PL7 4CIN 3CVA 1R2G 4PPI 4HNJ 2B48 6IJQ 6F46 6BF2 2ME8 2ME9 2MEJ 2M03 2M04 2LPC 2LP8 2PON 2O2M 2O2N 2O1Y 1YSG 1YSI 1YSN 1G5J 1LXL

Position

20q11.21

AA seq 233 aa
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK

NT seq 702 nt +upstreamnt +downstreamnt
atgtctcagagcaaccgggagctggtggttgactttctctcctacaagctttcccagaaa
ggatacagctggagtcagtttagtgatgtggaagagaacaggactgaggccccagaaggg
actgaatcggagatggagacccccagtgccatcaatggcaacccatcctggcacctggca
gacagccccgcggtgaatggagccactggccacagcagcagtttggatgcccgggaggtg
atccccatggcagcagtaaagcaagcgctgagggaggcaggcgacgagtttgaactgcgg
taccggcgggcattcagtgacctgacatcccagctccacatcaccccagggacagcatat
cagagctttgaacaggtagtgaatgaactcttccgggatggggtaaactggggtcgcatt
gtggcctttttctccttcggcggggcactgtgcgtggaaagcgtagacaaggagatgcag
gtattggtgagtcggatcgcagcttggatggccacttacctgaatgaccacctagagcct
tggatccaggagaacggcggctgggatacttttgtggaactctatgggaacaatgcagca
gccgagagccgaaagggccaggaacgcttcaaccgctggttcctgacgggcatgactgtg
gccggcgtggttctgctgggctcactcttcagtcggaaatga

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