KEGG   Homo sapiens (human): 60
Entry
60                CDS       T01001                                 
Symbol
ACTB, BKRNS, BNS, BRWS1, CSMH, DDS1, PS1TP5BP1, THC8
Name
(RefSeq) actin beta
  KO
K05692  actin beta/gamma 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03082  ATP-dependent chromatin remodeling
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa04530  Tight junction
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04670  Leukocyte transendothelial migration
hsa04714  Thermogenesis
hsa04810  Regulation of actin cytoskeleton
hsa04814  Motor proteins
hsa04820  Cytoskeleton in muscle cells
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04971  Gastric acid secretion
hsa05014  Amyotrophic lateral sclerosis
hsa05100  Bacterial invasion of epithelial cells
hsa05110  Vibrio cholerae infection
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05164  Influenza A
hsa05205  Proteoglycans in cancer
hsa05225  Hepatocellular carcinoma
hsa05410  Hypertrophic cardiomyopathy
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05414  Dilated cardiomyopathy
hsa05416  Viral myocarditis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06529  Thermogenesis
nt06539  Cytoskeleton in muscle cells
nt06541  Cytoskeleton in neurons
  Element
N00465  Deleted DMD to dystrophin-associated protein complex
N01066  ARNO-ARF-ACTB_G signaling pathway
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01078  EGF-EGFR-Actin signaling pathway
N01079  Shigella IpaC to Actin signaling pathway
N01080  ITGA/B-TALIN/VINCULIN signaling pathway
N01081  Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway
N01086  Escherichia EspT to RAC signaling pathway
N01092  Escherichia Eae/Tir to Actin signaling pathway
N01094  Escherichia Eae/Tir/TccP to Actin signaling pathway
N01096  Escherichia Map to CDC42 signaling pathway
N01128  Salmonella SopE to RAC signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01161  Actin polymerization
N01162  Mutation-caused aberrant PFN1 to actin polymerization
N01287  Tight junction-Actin signaling pathway
N01304  ANXA2-S100A10-regulated actin cytoskeleton
N01305  Salmonella SopB to ANXA2-S100A10-regulated actin cytoskeleton
N01688  ADRB3-UCP1 signaling pathway
N01815  Vinculin-talin-integrin macromolecular complex
N01837  Regulation of neurite extension, NAV1-TRIO
N01838  Regulation of synaptic plasticity, p140Cap
N01848  Membrane-associated periodic skeleton (MPS)
N01849  Axonal actin ring structure
N01850  MYO5B-mediated vesicle transport
N01851  MYO5A-mediated vesicle transport
N01852  MYO6-mediated vesicle transport
Disease
H00978  Thrombocytopenia (THC)
H01255  Juvenile-onset dystonia
H02023  Baraitser-Winter syndrome
H02716  Becker nevus syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    60 (ACTB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    60 (ACTB)
   04390 Hippo signaling pathway
    60 (ACTB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    60 (ACTB)
  09143 Cell growth and death
   04210 Apoptosis
    60 (ACTB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    60 (ACTB)
   04520 Adherens junction
    60 (ACTB)
   04530 Tight junction
    60 (ACTB)
  09142 Cell motility
   04814 Motor proteins
    60 (ACTB)
   04820 Cytoskeleton in muscle cells
    60 (ACTB)
   04810 Regulation of actin cytoskeleton
    60 (ACTB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    60 (ACTB)
   04613 Neutrophil extracellular trap formation
    60 (ACTB)
   04670 Leukocyte transendothelial migration
    60 (ACTB)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    60 (ACTB)
   04919 Thyroid hormone signaling pathway
    60 (ACTB)
  09154 Digestive system
   04971 Gastric acid secretion
    60 (ACTB)
  09159 Environmental adaptation
   04714 Thermogenesis
    60 (ACTB)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    60 (ACTB)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    60 (ACTB)
  09172 Infectious disease: viral
   05164 Influenza A
    60 (ACTB)
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    60 (ACTB)
   05130 Pathogenic Escherichia coli infection
    60 (ACTB)
   05132 Salmonella infection
    60 (ACTB)
   05131 Shigellosis
    60 (ACTB)
   05135 Yersinia infection
    60 (ACTB)
   05100 Bacterial invasion of epithelial cells
    60 (ACTB)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    60 (ACTB)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    60 (ACTB)
   05410 Hypertrophic cardiomyopathy
    60 (ACTB)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    60 (ACTB)
   05414 Dilated cardiomyopathy
    60 (ACTB)
   05416 Viral myocarditis
    60 (ACTB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    60 (ACTB)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    60 (ACTB)
   03036 Chromosome and associated proteins [BR:hsa03036]
    60 (ACTB)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    60 (ACTB)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    60 (ACTB)
   04147 Exosome [BR:hsa04147]
    60 (ACTB)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Coactivators
    BAF/PBAF complex
     60 (ACTB)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Factors that have mRNA localization signals
     60 (ACTB)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HAT complexes
    TIP60 complex
     60 (ACTB)
    NuA4 complex
     60 (ACTB)
  Chromatin remodeling factors
   BAF complex
    60 (ACTB)
   PBAF complex
    60 (ACTB)
   GBAF(ncBAF) complex
    60 (ACTB)
   SWR1 complex
    60 (ACTB)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Actin cytoskeleton organization
    60 (ACTB)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actins
     60 (ACTB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   60 (ACTB)
SSDB
Motif
Pfam: Actin
Other DBs
NCBI-GeneID: 60
NCBI-ProteinID: NP_001092
OMIM: 102630
HGNC: 132
Ensembl: ENSG00000075624
UniProt: P60709 Q1KLZ0
Structure
Position
7:complement(5527148..5530601)
AA seq 375 aa
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
NT seq 1128 nt   +upstreamnt  +downstreamnt
atggatgatgatatcgccgcgctcgtcgtcgacaacggctccggcatgtgcaaggccggc
ttcgcgggcgacgatgccccccgggccgtcttcccctccatcgtggggcgccccaggcac
cagggcgtgatggtgggcatgggtcagaaggattcctatgtgggcgacgaggcccagagc
aagagaggcatcctcaccctgaagtaccccatcgagcacggcatcgtcaccaactgggac
gacatggagaaaatctggcaccacaccttctacaatgagctgcgtgtggctcccgaggag
caccccgtgctgctgaccgaggcccccctgaaccccaaggccaaccgcgagaagatgacc
cagatcatgtttgagaccttcaacaccccagccatgtacgttgctatccaggctgtgcta
tccctgtacgcctctggccgtaccactggcatcgtgatggactccggtgacggggtcacc
cacactgtgcccatctacgaggggtatgccctcccccatgccatcctgcgtctggacctg
gctggccgggacctgactgactacctcatgaagatcctcaccgagcgcggctacagcttc
accaccacggccgagcgggaaatcgtgcgtgacattaaggagaagctgtgctacgtcgcc
ctggacttcgagcaagagatggccacggctgcttccagctcctccctggagaagagctac
gagctgcctgacggccaggtcatcaccattggcaatgagcggttccgctgccctgaggca
ctcttccagccttccttcctgggcatggagtcctgtggcatccacgaaactaccttcaac
tccatcatgaagtgtgacgtggacatccgcaaagacctgtacgccaacacagtgctgtct
ggcggcaccaccatgtaccctggcattgccgacaggatgcagaaggagatcactgccctg
gcacccagcacaatgaagatcaagatcattgctcctcctgagcgcaagtactccgtgtgg
atcggcggctccatcctggcctcgctgtccaccttccagcagatgtggatcagcaagcag
gagtatgacgagtccggcccctccatcgtccaccgcaaatgcttctag

  All links  
Disease (6)   
   OMIM (6)   
Gene (759)   
   RefGene (456)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (298)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (81)   
   RefSeq(nuc) (1)   
   GenBank (40)   
   EMBL (40)   
3D Structure (52)   
   PDB (52)   
Protein domain (1)   
   Pfam (1)   
All databases (903)   

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