KEGG   Homo sapiens (human): 6098
Entry
6098              CDS       T01001                                 
Symbol
ROS1, MCF3, ROS, c-ros-1
Name
(RefSeq) ROS proto-oncogene 1, receptor tyrosine kinase
  KO
K05088  proto-oncogene tyrosine-protein kinase ROS [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Disease
H00014  Non-small cell lung cancer
Drug target
Crizotinib: D09731<JP/US>
Entrectinib: D10926<JP/US>
Lorlatinib: D11012<JP/US>
Repotrectinib: D11454<JP/US>
Taletrectinib (DG03226): D12363 D12364
Zidesamtinib: D12899
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6098 (ROS1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     6098 (ROS1)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  ROS family
   6098 (ROS1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr fn3 Pkinase Ig_DSCAM-DSCAML_C Pur_ac_phosph_N
Other DBs
NCBI-GeneID: 6098
NCBI-ProteinID: NP_002935
OMIM: 165020
HGNC: 10261
Ensembl: ENSG00000047936
UniProt: P08922
Structure
Position
6:complement(117287353..117425942)
AA seq 2347 aa
MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG
CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK
SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS
PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD
AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS
LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR
IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN
GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST
FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF
GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL
GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW
SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS
DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD
IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL
SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING
FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG
NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP
YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT
KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA
DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE
GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV
KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ
QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML
AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP
DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS
SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA
VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL
LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL
NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST
SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN
LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET
SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN
ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI
GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE
CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS
GYGDGSD
NT seq 7044 nt   +upstreamnt  +downstreamnt
atgaagaacatttactgtcttattccgaagcttgtcaattttgcaactcttggctgccta
tggatttctgtggtgcagtgtacagttttaaatagctgcctaaagtcgtgtgtaactaat
ctgggccagcagcttgaccttggcacaccacataatctgagtgaaccgtgtatccaagga
tgtcacttttggaactctgtagatcagaaaaactgtgctttaaagtgtcgggagtcgtgt
gaggttggctgtagcagcgcggaaggtgcatatgaagaggaagtactggaaaatgcagac
ctaccaactgctccctttgcttcttccattggaagccacaatatgacattacgatggaaa
tctgcaaacttctctggagtaaaatacatcattcagtggaaatatgcacaacttctggga
agctggacttatactaagactgtgtccagaccgtcctatgtggtcaagcccctgcacccc
ttcactgagtacattttccgagtggtttggatcttcacagcgcagctgcagctctactcc
cctccaagtcccagttacaggactcatcctcatggagttcctgaaactgcacctttgatt
aggaatattgagagctcaagtcccgacactgtggaagtcagctgggatccacctcaattc
ccaggtggacctattttgggttataacttaaggctgatcagcaaaaatcaaaaattagat
gcagggacacagagaaccagtttccagttttactccactttaccaaatactatctacagg
ttttctattgcagcagtaaatgaagttggtgagggtccagaagcagaatctagtattacc
acttcatcttcagcagttcaacaagaggaacagtggctctttttatccagaaaaacttct
ctaagaaagagatctttaaaacatttagtagatgaagcacattgccttcggttggatgct
atataccataatattacaggaatatctgttgatgtccaccagcaaattgtttatttctct
gaaggaactctcatatgggcgaagaaggctgccaacatgtctgatgtatctgacctgaga
attttttacagaggttcaggattaatttcttctatctccatagattggctttatcaaaga
atgtatttcatcatggatgaactggtatgtgtctgtgatttagagaactgctcaaacatc
gaggaaattactccaccctctattagtgcacctcaaaaaattgtggctgattcatacaat
gggtatgtcttttacctcctgagagatggcatttatagagcagaccttcctgtaccatct
ggccggtgtgcagaagctgtgcgtattgtggagagttgcacgttaaaggactttgcaatc
aagccacaagccaagcgaatcatttacttcaatgacactgcccaagtcttcatgtcaaca
tttctggatggctctgcttcccatctcatcctacctcgcatcccctttgctgatgtgaaa
agttttgcttgtgaaaacaatgactttcttgtcacagatggcaaggtcattttccaacag
gatgctttgtcttttaatgaattcatcgtgggatgtgacctgagtcacatagaagaattt
gggtttggtaacttggtcatctttggctcatcctcccagctgcaccctctgccaggccgc
ccgcaggagctttcggtgctgtttggctctcaccaggctcttgttcaatggaagcctcct
gcccttgccataggagccaatgtcatcctgatcagtgatattattgaactctttgaatta
ggcccttctgcctggcagaactggacctatgaggtgaaagtatccacccaagaccctcct
gaagtcactcatattttcttgaacataagtggaaccatgctgaatgtacctgagctgcag
agtgctatgaaatacaaggtttctgtgagagcaagttctccaaagaggccaggcccctgg
tcagagccctcagtgggtactaccctggtgccagctagtgaaccaccatttatcatggct
gtgaaagaagatgggctttggagtaaaccattaaatagctttggcccaggagagttctta
tcctctgatataggaaatgtgtcagacatggattggtataacaacagcctctactacagt
gacacgaaaggcgacgtttttgtgtggctgctgaatgggacggatatctcagagaattat
cacctacccagcattgcaggagcaggggctttagcttttgagtggctgggtcactttctc
tactgggctggaaagacatatgtgatacaaaggcagtctgtgttgacgggacacacagac
attgttacccacgtgaagctattggtgaatgacatggtggtggattcagttggtggatat
ctctactggaccacactctattcagtggaaagcaccagactaaatggggaaagttccctt
gtactacagacacagccttggttttctgggaaaaaggtaattgctctaactttagacctc
agtgatgggctcctgtattggttggttcaagacagtcaatgtattcacctgtacacagct
gttcttcggggacagagcactggggataccaccatcacagaatttgcagcctggagtact
tctgaaatttcccagaatgcactgatgtactatagtggtcggctgttctggatcaatggc
tttaggattatcacaactcaagaaataggtcagaaaaccagtgtctctgttttggaacca
gccagatttaatcagttcacaattattcagacatcccttaagcccctgccagggaacttt
tcctttacccctaaggttattccagattctgttcaagagtcttcatttaggattgaagga
aatgcttcaagttttcaaatcctgtggaatggtccccctgcggtagactggggtgtagtt
ttctacagtgtagaatttagtgctcattctaagttcttggctagtgaacaacactcttta
cctgtatttactgtggaaggactggaaccttatgccttatttaatctttctgtcactcct
tatacctactggggaaagggccccaaaacatctctgtcacttcgagcacctgaaacagtt
ccatcagcaccagagaaccccagaatatttatattaccaagtggaaaatgctgcaacaag
aatgaagttgtggtggaatttaggtggaacaaacctaagcatgaaaatggggtgttaaca
aaatttgaaattttctacaatatatccaatcaaagtattacaaacaaaacatgtgaagac
tggattgctgtcaatgtcactccctcagtgatgtcttttcaacttgaaggcatgagtccc
agatgctttattgccttccaggttagggcctttacatctaaggggccaggaccatatgct
gacgttgtaaagtctacaacatcagaaatcaacccatttcctcacctcataactcttctt
ggtaacaagatagtttttttagatatggatcaaaatcaagttgtgtggacgttttcagca
gaaagagttatcagtgccgtttgctacacagctgataatgagatgggatattatgctgaa
ggggactcactctttcttctgcacttgcacaatcgctctagctctgagcttttccaagat
tcactggtttttgatatcacagttattacaattgactggatttcaaggcacctctacttt
gcactgaaagaatcacaaaatggaatgcaagtatttgatgttgatcttgaacacaaggtg
aaatatcccagagaggtgaagattcacaataggaattcaacaataatttctttttctgta
tatcctcttttaagtcgcttgtattggacagaagtttccaattttggctaccagatgttc
tactacagtattatcagtcacaccttgcaccgaattctgcaacccacagctacaaaccaa
caaaacaaaaggaatcaatgttcttgtaatgtgactgaatttgagttaagtggagcaatg
gctattgatacctctaacctagagaaaccattgatatactttgccaaagcacaagagatc
tgggcaatggatctggaaggctgtcagtgttggagagttatcacagtacctgctatgctc
gcaggaaaaacccttgttagcttaactgtggatggagatcttatatactggatcatcaca
gcaaaggacagcacacagatttatcaggcaaagaaaggaaatggggccatcgtttcccag
gtgaaggccctaaggagtaggcatatcttggcttacagttcagttatgcagccttttcca
gataaagcgtttctgtctctagcttcagacactgtggaaccaactatacttaatgccact
aacactagcctcacaatcagattacctctggccaagacaaacctcacatggtatggcatc
accagccctactccaacatacctggtttattatgcagaagttaatgacaggaaaaacagc
tctgacttgaaatatagaattctggaatttcaggacagtatagctcttattgaagattta
caaccattttcaacatacatgatacagatagctgtaaaaaattattattcagatcctttg
gaacatttaccaccaggaaaagagatttggggaaaaactaaaaatggagtaccagaggca
gtgcagctcattaatacaactgtgcggtcagacaccagcctcattatatcttggagagaa
tctcacaagccaaatggacctaaagaatcagtccgttatcagttggcaatctcacacctg
gccctaattcctgaaactcctctaagacaaagtgaatttccaaatggaaggctcactctc
cttgttactagactgtctggtggaaatatttatgtgttaaaggttcttgcctgccactct
gaggaaatgtggtgtacagagagtcatcctgtcactgtggaaatgtttaacacaccagag
aaaccttattccttggttccagagaacactagtttgcaatttaattggaaggctccattg
aatgttaacctcatcagattttgggttgagctacagaagtggaaatacaatgagttttac
catgttaaaacttcatgcagccaaggtcctgcttatgtctgtaatatcacaaatctacaa
ccttatacttcatataatgtcagagtagtggtggtttataagacgggagaaaatagcacc
tcacttccagaaagctttaagacaaaagctggagtcccaaataaaccaggcattcccaaa
ttactagaagggagtaaaaattcaatacagtgggagaaagctgaagataatggatgtaga
attacatactatatccttgagataagaaagagcacttcaaataatttacagaaccagaat
ttaaggtggaagatgacatttaatggatcctgcagtagtgtttgcacatggaagtccaaa
aacctgaaaggaatatttcagttcagagtagtagctgcaaataatctagggtttggtgaa
tatagtggaatcagtgagaatattatattagttggagatgatttttggataccagaaaca
agtttcatacttactattatagttggaatatttctggttgttacaatcccactgaccttt
gtctggcatagaagattaaagaatcaaaaaagtgccaaggaaggggtgacagtgcttata
aacgaagacaaagagttggctgagctgcgaggtctggcagccggagtaggcctggctaat
gcctgctatgcaatacatactcttccaacccaagaggagattgaaaatcttcctgccttc
cctcgggaaaaactgactctgcgtctcttgctgggaagtggagcctttggagaagtgtat
gaaggaacagcagtggacatcttaggagttggaagtggagaaatcaaagtagcagtgaag
actttgaagaagggttccacagaccaggagaagattgaattcctgaaggaggcacatctg
atgagcaaatttaatcatcccaacattctgaagcagcttggagtttgtctgctgaatgaa
ccccaatacattatcctggaactgatggagggaggagaccttcttacttatttgcgtaaa
gcccggatggcaacgttttatggtcctttactcaccttggttgaccttgtagacctgtgt
gtagatatttcaaaaggctgtgtctacttggaacggatgcatttcattcacagggatctg
gcagctagaaattgccttgtttccgtgaaagactataccagtccacggatagtgaagatt
ggagactttggactcgccagagacatctataaaaatgattactatagaaagagaggggaa
ggcctgctcccagttcggtggatggctccagaaagtttgatggatggaatcttcactact
caatctgatgtatggtcttttggaattctgatttgggagattttaactcttggtcatcag
ccttatccagctcattccaaccttgatgtgttaaactatgtgcaaacaggagggagactg
gagccaccaagaaattgtcctgatgatctgtggaatttaatgacccagtgctgggctcaa
gaacccgaccaaagacctacttttcatagaattcaggaccaacttcagttattcagaaat
tttttcttaaatagcatttataagtccagagatgaagcaaacaacagtggagtcataaat
gaaagctttgaaggtgaagatggcgatgtgatttgtttgaattcagatgacattatgcca
gttgctttaatggaaacgaagaaccgagaagggttaaactatatggtacttgctacagaa
tgtggccaaggtgaagaaaagtctgagggtcctctaggctcccaggaatctgaatcttgt
ggtctgaggaaagaagagaaggaaccacatgcagacaaagatttctgccaagaaaaacaa
gtggcttactgcccttctggcaagcctgaaggcctgaactatgcctgtctcactcacagt
ggatatggagatgggtctgattaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (33)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (33)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (31)   
DNA sequence (49)   
   RefSeq(nuc) (31)   
   GenBank (9)   
   EMBL (9)   
3D Structure (4)   
   PDB (4)   
Protein domain (5)   
   Pfam (5)   
All databases (125)   

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