KEGG   Homo sapiens (human): 6098
Entry
6098              CDS       T01001                                 
Symbol
ROS1, MCF3, ROS, c-ros-1
Name
(RefSeq) ROS proto-oncogene 1, receptor tyrosine kinase
  KO
K05088  proto-oncogene tyrosine-protein kinase ROS [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Network
  Element
N10003  First-generation tyrosine kinase inhibitor to ALK fusion
Disease
H00014  Non-small cell lung cancer
Drug target
Crizotinib: D09731<JP/US>
Entrectinib: D10926<JP/US>
Lorlatinib: D11012<JP/US>
Repotrectinib: D11454
Taletrectinib (DG03226): D12363 D12364
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6098 (ROS1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     6098 (ROS1)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  ROS family
   6098 (ROS1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr fn3 Pkinase Pur_ac_phosph_N
Other DBs
NCBI-GeneID: 6098
NCBI-ProteinID: NP_002935
OMIM: 165020
HGNC: 10261
Ensembl: ENSG00000047936
UniProt: P08922
Structure
Position
6:complement(117287353..117425942)
AA seq 2347 aa
MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG
CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK
SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS
PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD
AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS
LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR
IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN
GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST
FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF
GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL
GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW
SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS
DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD
IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL
SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING
FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG
NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP
YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT
KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA
DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE
GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV
KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ
QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML
AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP
DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS
SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA
VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL
LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL
NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST
SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN
LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET
SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN
ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI
GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE
CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS
GYGDGSD
NT seq 7044 nt   +upstreamnt  +downstreamnt
atgaagaacatttactgtcttattccgaagcttgtcaattttgcaactcttggctgccta
tggatttctgtggtgcagtgtacagttttaaatagctgcctaaagtcgtgtgtaactaat
ctgggccagcagcttgaccttggcacaccacataatctgagtgaaccgtgtatccaagga
tgtcacttttggaactctgtagatcagaaaaactgtgctttaaagtgtcgggagtcgtgt
gaggttggctgtagcagcgcggaaggtgcatatgaagaggaagtactggaaaatgcagac
ctaccaactgctccctttgcttcttccattggaagccacaatatgacattacgatggaaa
tctgcaaacttctctggagtaaaatacatcattcagtggaaatatgcacaacttctggga
agctggacttatactaagactgtgtccagaccgtcctatgtggtcaagcccctgcacccc
ttcactgagtacattttccgagtggtttggatcttcacagcgcagctgcagctctactcc
cctccaagtcccagttacaggactcatcctcatggagttcctgaaactgcacctttgatt
aggaatattgagagctcaagtcccgacactgtggaagtcagctgggatccacctcaattc
ccaggtggacctattttgggttataacttaaggctgatcagcaaaaatcaaaaattagat
gcagggacacagagaaccagtttccagttttactccactttaccaaatactatctacagg
ttttctattgcagcagtaaatgaagttggtgagggtccagaagcagaatctagtattacc
acttcatcttcagcagttcaacaagaggaacagtggctctttttatccagaaaaacttct
ctaagaaagagatctttaaaacatttagtagatgaagcacattgccttcggttggatgct
atataccataatattacaggaatatctgttgatgtccaccagcaaattgtttatttctct
gaaggaactctcatatgggcgaagaaggctgccaacatgtctgatgtatctgacctgaga
attttttacagaggttcaggattaatttcttctatctccatagattggctttatcaaaga
atgtatttcatcatggatgaactggtatgtgtctgtgatttagagaactgctcaaacatc
gaggaaattactccaccctctattagtgcacctcaaaaaattgtggctgattcatacaat
gggtatgtcttttacctcctgagagatggcatttatagagcagaccttcctgtaccatct
ggccggtgtgcagaagctgtgcgtattgtggagagttgcacgttaaaggactttgcaatc
aagccacaagccaagcgaatcatttacttcaatgacactgcccaagtcttcatgtcaaca
tttctggatggctctgcttcccatctcatcctacctcgcatcccctttgctgatgtgaaa
agttttgcttgtgaaaacaatgactttcttgtcacagatggcaaggtcattttccaacag
gatgctttgtcttttaatgaattcatcgtgggatgtgacctgagtcacatagaagaattt
gggtttggtaacttggtcatctttggctcatcctcccagctgcaccctctgccaggccgc
ccgcaggagctttcggtgctgtttggctctcaccaggctcttgttcaatggaagcctcct
gcccttgccataggagccaatgtcatcctgatcagtgatattattgaactctttgaatta
ggcccttctgcctggcagaactggacctatgaggtgaaagtatccacccaagaccctcct
gaagtcactcatattttcttgaacataagtggaaccatgctgaatgtacctgagctgcag
agtgctatgaaatacaaggtttctgtgagagcaagttctccaaagaggccaggcccctgg
tcagagccctcagtgggtactaccctggtgccagctagtgaaccaccatttatcatggct
gtgaaagaagatgggctttggagtaaaccattaaatagctttggcccaggagagttctta
tcctctgatataggaaatgtgtcagacatggattggtataacaacagcctctactacagt
gacacgaaaggcgacgtttttgtgtggctgctgaatgggacggatatctcagagaattat
cacctacccagcattgcaggagcaggggctttagcttttgagtggctgggtcactttctc
tactgggctggaaagacatatgtgatacaaaggcagtctgtgttgacgggacacacagac
attgttacccacgtgaagctattggtgaatgacatggtggtggattcagttggtggatat
ctctactggaccacactctattcagtggaaagcaccagactaaatggggaaagttccctt
gtactacagacacagccttggttttctgggaaaaaggtaattgctctaactttagacctc
agtgatgggctcctgtattggttggttcaagacagtcaatgtattcacctgtacacagct
gttcttcggggacagagcactggggataccaccatcacagaatttgcagcctggagtact
tctgaaatttcccagaatgcactgatgtactatagtggtcggctgttctggatcaatggc
tttaggattatcacaactcaagaaataggtcagaaaaccagtgtctctgttttggaacca
gccagatttaatcagttcacaattattcagacatcccttaagcccctgccagggaacttt
tcctttacccctaaggttattccagattctgttcaagagtcttcatttaggattgaagga
aatgcttcaagttttcaaatcctgtggaatggtccccctgcggtagactggggtgtagtt
ttctacagtgtagaatttagtgctcattctaagttcttggctagtgaacaacactcttta
cctgtatttactgtggaaggactggaaccttatgccttatttaatctttctgtcactcct
tatacctactggggaaagggccccaaaacatctctgtcacttcgagcacctgaaacagtt
ccatcagcaccagagaaccccagaatatttatattaccaagtggaaaatgctgcaacaag
aatgaagttgtggtggaatttaggtggaacaaacctaagcatgaaaatggggtgttaaca
aaatttgaaattttctacaatatatccaatcaaagtattacaaacaaaacatgtgaagac
tggattgctgtcaatgtcactccctcagtgatgtcttttcaacttgaaggcatgagtccc
agatgctttattgccttccaggttagggcctttacatctaaggggccaggaccatatgct
gacgttgtaaagtctacaacatcagaaatcaacccatttcctcacctcataactcttctt
ggtaacaagatagtttttttagatatggatcaaaatcaagttgtgtggacgttttcagca
gaaagagttatcagtgccgtttgctacacagctgataatgagatgggatattatgctgaa
ggggactcactctttcttctgcacttgcacaatcgctctagctctgagcttttccaagat
tcactggtttttgatatcacagttattacaattgactggatttcaaggcacctctacttt
gcactgaaagaatcacaaaatggaatgcaagtatttgatgttgatcttgaacacaaggtg
aaatatcccagagaggtgaagattcacaataggaattcaacaataatttctttttctgta
tatcctcttttaagtcgcttgtattggacagaagtttccaattttggctaccagatgttc
tactacagtattatcagtcacaccttgcaccgaattctgcaacccacagctacaaaccaa
caaaacaaaaggaatcaatgttcttgtaatgtgactgaatttgagttaagtggagcaatg
gctattgatacctctaacctagagaaaccattgatatactttgccaaagcacaagagatc
tgggcaatggatctggaaggctgtcagtgttggagagttatcacagtacctgctatgctc
gcaggaaaaacccttgttagcttaactgtggatggagatcttatatactggatcatcaca
gcaaaggacagcacacagatttatcaggcaaagaaaggaaatggggccatcgtttcccag
gtgaaggccctaaggagtaggcatatcttggcttacagttcagttatgcagccttttcca
gataaagcgtttctgtctctagcttcagacactgtggaaccaactatacttaatgccact
aacactagcctcacaatcagattacctctggccaagacaaacctcacatggtatggcatc
accagccctactccaacatacctggtttattatgcagaagttaatgacaggaaaaacagc
tctgacttgaaatatagaattctggaatttcaggacagtatagctcttattgaagattta
caaccattttcaacatacatgatacagatagctgtaaaaaattattattcagatcctttg
gaacatttaccaccaggaaaagagatttggggaaaaactaaaaatggagtaccagaggca
gtgcagctcattaatacaactgtgcggtcagacaccagcctcattatatcttggagagaa
tctcacaagccaaatggacctaaagaatcagtccgttatcagttggcaatctcacacctg
gccctaattcctgaaactcctctaagacaaagtgaatttccaaatggaaggctcactctc
cttgttactagactgtctggtggaaatatttatgtgttaaaggttcttgcctgccactct
gaggaaatgtggtgtacagagagtcatcctgtcactgtggaaatgtttaacacaccagag
aaaccttattccttggttccagagaacactagtttgcaatttaattggaaggctccattg
aatgttaacctcatcagattttgggttgagctacagaagtggaaatacaatgagttttac
catgttaaaacttcatgcagccaaggtcctgcttatgtctgtaatatcacaaatctacaa
ccttatacttcatataatgtcagagtagtggtggtttataagacgggagaaaatagcacc
tcacttccagaaagctttaagacaaaagctggagtcccaaataaaccaggcattcccaaa
ttactagaagggagtaaaaattcaatacagtgggagaaagctgaagataatggatgtaga
attacatactatatccttgagataagaaagagcacttcaaataatttacagaaccagaat
ttaaggtggaagatgacatttaatggatcctgcagtagtgtttgcacatggaagtccaaa
aacctgaaaggaatatttcagttcagagtagtagctgcaaataatctagggtttggtgaa
tatagtggaatcagtgagaatattatattagttggagatgatttttggataccagaaaca
agtttcatacttactattatagttggaatatttctggttgttacaatcccactgaccttt
gtctggcatagaagattaaagaatcaaaaaagtgccaaggaaggggtgacagtgcttata
aacgaagacaaagagttggctgagctgcgaggtctggcagccggagtaggcctggctaat
gcctgctatgcaatacatactcttccaacccaagaggagattgaaaatcttcctgccttc
cctcgggaaaaactgactctgcgtctcttgctgggaagtggagcctttggagaagtgtat
gaaggaacagcagtggacatcttaggagttggaagtggagaaatcaaagtagcagtgaag
actttgaagaagggttccacagaccaggagaagattgaattcctgaaggaggcacatctg
atgagcaaatttaatcatcccaacattctgaagcagcttggagtttgtctgctgaatgaa
ccccaatacattatcctggaactgatggagggaggagaccttcttacttatttgcgtaaa
gcccggatggcaacgttttatggtcctttactcaccttggttgaccttgtagacctgtgt
gtagatatttcaaaaggctgtgtctacttggaacggatgcatttcattcacagggatctg
gcagctagaaattgccttgtttccgtgaaagactataccagtccacggatagtgaagatt
ggagactttggactcgccagagacatctataaaaatgattactatagaaagagaggggaa
ggcctgctcccagttcggtggatggctccagaaagtttgatggatggaatcttcactact
caatctgatgtatggtcttttggaattctgatttgggagattttaactcttggtcatcag
ccttatccagctcattccaaccttgatgtgttaaactatgtgcaaacaggagggagactg
gagccaccaagaaattgtcctgatgatctgtggaatttaatgacccagtgctgggctcaa
gaacccgaccaaagacctacttttcatagaattcaggaccaacttcagttattcagaaat
tttttcttaaatagcatttataagtccagagatgaagcaaacaacagtggagtcataaat
gaaagctttgaaggtgaagatggcgatgtgatttgtttgaattcagatgacattatgcca
gttgctttaatggaaacgaagaaccgagaagggttaaactatatggtacttgctacagaa
tgtggccaaggtgaagaaaagtctgagggtcctctaggctcccaggaatctgaatcttgt
ggtctgaggaaagaagagaaggaaccacatgcagacaaagatttctgccaagaaaaacaa
gtggcttactgcccttctggcaagcctgaaggcctgaactatgcctgtctcactcacagt
ggatatggagatgggtctgattaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Network (1)   
   KEGG NETWORK (1)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Drug (6)   
   KEGG DRUG (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (33)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (31)   
DNA sequence (49)   
   RefSeq(nuc) (31)   
   GenBank (9)   
   EMBL (9)   
3D Structure (4)   
   PDB (4)   
Protein domain (4)   
   Pfam (4)   
All databases (138)   

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