KEGG   Homo sapiens (human): 610Help
Entry
610               CDS       T01001                                 

Gene name
HCN2, BCNG-2, BCNG2, HAC-1
Definition
(RefSeq) hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
  KO
K04955  hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04929  GnRH secretion
Drug target
Ivabradine (DG00246): D07165 D08095
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    610 (HCN2)
 09150 Organismal Systems
  09152 Endocrine system
   04929 GnRH secretion
    610 (HCN2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    610 (HCN2)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Cyclic nucleotide-gated channel (HCN)
   610 (HCN2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ion_trans Ion_trans_N cNMP_binding Ion_trans_2
Motif
Other DBs
NCBI-GeneID: 610
NCBI-ProteinID: NP_001185
OMIM: 602781
HGNC: 4846
Ensembl: ENSG00000099822
Vega: OTTHUMG00000180590
Pharos: Q9UL51(Tclin)
UniProt: Q9UL51
Structure
PDB: 

Position
19p13.3
AA seq 889 aa AA seqDB search
MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEA
LPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARG
PKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSL
RMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET
TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIP
VDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDL
ASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFK
AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY
KQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVA
SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMK
LSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRL
DRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPP
PQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP
PGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRP
ASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL
NT seq 2670 nt NT seq  +upstreamnt  +downstreamnt
atggacgcgcgcgggggcggcgggcggcccggggagagcccgggcgcgacccccgcgccg
gggccgccgccgccgccgccgcccgcgcccccccaacagcagccgccgccgccgccgccg
cccgcgccccccccgggccccgggcccgcgcccccccagcacccgccccgggccgaggcg
ttgcccccggaggcggcggatgagggcggcccgcggggccggctccgcagccgcgacagc
tcgtgcggccgccccggcaccccgggcgcggcgagcacggccaagggcagcccgaacggc
gagtgcgggcgcggcgagccgcagtgcagccccgcggggcccgagggcccggcgcggggg
cccaaggtgtcgttctcgtgccgcggggcggcctcggggcccgcgccggggccggggccg
gcggaggaggcgggcagcgaggaggcgggcccggcgggggagccgcgcggcagccaggcc
agcttcatgcagcgccagttcggcgcgctcctgcagccgggcgtcaacaagttctcgctg
cggatgttcggcagccagaaggccgtggagcgcgagcaggagcgcgtcaagtcggcgggg
gcctggatcatccacccgtacagcgacttcaggttctactgggacttcaccatgctgctg
ttcatggtgggaaacctcatcatcatcccagtgggcatcaccttcttcaaggatgagacc
actgccccgtggatcgtgttcaacgtggtctcggacaccttcttcctcatggacctggtg
ttgaacttccgcaccggcattgtgatcgaggacaacacggagatcatcctggaccccgag
aagatcaagaagaagtatctgcgcacgtggttcgtggtggacttcgtgtcctccatcccc
gtggactacatcttccttatcgtggagaagggcattgactccgaggtctacaagacggca
cgcgccctgcgcatcgtgcgcttcaccaagatcctcagcctcctgcggctgctgcgcctc
tcacgcctgatccgctacatccatcagtgggaggagatcttccacatgacctatgacctg
gccagcgcggtgatgaggatctgcaatctcatcagcatgatgctgctgctctgccactgg
gacggctgcctgcagttcctggtgcctatgctgcaggacttcccgcgcaactgctgggtg
tccatcaatggcatggtgaaccactcgtggagtgaactgtactccttcgcactcttcaag
gccatgagccacatgctgtgcatcgggtacggccggcaggcgcccgagagcatgacggac
atctggctgaccatgctcagcatgattgtgggtgccacctgctacgccatgttcatcggc
cacgccactgccctcatccagtcgctggactcctcgcggcgccagtaccaggagaagtac
aagcaggtggagcagtacatgtccttccacaagctgccagctgacttccgccagaagatc
cacgactactatgagcaccgttaccagggcaagatgtttgacgaggacagcatcctgggc
gagctcaacgggcccctgcgggaggagatcgtcaacttcaactgccggaagctggtggcc
tccatgccgctgttcgccaacgccgaccccaacttcgtcacggccatgctgaccaagctc
aagttcgaggtcttccagccgggtgactacatcatccgcgaaggcaccatcgggaagaag
atgtacttcatccagcacggcgtggtcagcgtgctcactaagggcaacaaggagatgaag
ctgtccgatggctcctacttcggggagatctgcctgctcacccggggccgccgcacggcg
agcgtgcgggctgacacctactgccgcctctattcgctgagcgtggacaacttcaacgag
gtgctggaggagtaccccatgatgcggcgcgccttcgagacggtggccatcgaccgcctg
gaccgcatcggcaagaagaattccatcctcctgcacaaggtgcagcatgacctcaactcg
ggcgtattcaacaaccaggagaacgccatcatccaggagatcgtcaagtacgaccgcgag
atggtgcagcaggccgagctgggtcagcgcgtgggcctcttcccgccgccgccgccgccg
ccgcaggtcacctcggccatcgccacgctgcagcaggcggcggccatgagcttctgcccg
caggtggcgcggccgctcgtggggccgctggcgctcggctcgccgcgcctcgtgcgccgc
ccgcccccggggcccgcacctgccgccgcctcacccgggcccccgccccccgccagcccc
ccgggcgcgcccgccagcccccgggcaccgcggacctcgccctacggcggcctgcccgcc
gccccccttgctgggcccgccctgcccgcgcgccgcctgagccgcgcgtcgcgcccactg
tccgcctcgcagccctcgctgcctcacggcgcccccggccccgcggcctccacacgcccg
gccagcagctccacaccgcgcttggggcccacgcccgctgcccgggccgccgcgcccagc
ccggaccgcagggactcggcctcacccggcgccgccggcggcctggacccccaggactcc
gcgcgctcgcgcctctcgtccaacttgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (67)   
   KEGG ORTHOLOGY (1)   
   RefGene (59)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (11)   
   RefSeq(nuc) (1)   
   GenBank (5)   
   EMBL (5)   
Protein domain (4)   
   Pfam (4)   
All databases (93)   

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