KEGG   Homo sapiens (human): 6257
Entry
6257              CDS       T01001                                 
Symbol
RXRB, DAUDI6, H-2RIIBP, NR2B2, RCoR-1, RXR-beta, RXRbeta
Name
(RefSeq) retinoid X receptor beta
  KO
K08525  retinoid X receptor beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa03320  PPAR signaling pathway
hsa04659  Th17 cell differentiation
hsa04919  Thyroid hormone signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05216  Thyroid cancer
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05226  Gastric cancer
hsa05417  Lipid and atherosclerosis
Network
nt06240  Transcription
nt06274  Thyroid cancer
nt06322  TRH-TSH-TH signaling
  Element
N00126  PAX8-PPARG fusion to PPARG-mediated transcription
N00798  Thyroid hormone signaling pathway
N00799  Mutation-inactivated THRA to thyroid hormone signaling pathway
N00800  Mutation-inactivated THRB to thyroid hormone signaling pathway
Drug target
Acitretin: D02754<US>
Adapalene: D01112<JP/US>
Alitretinoin: D02815<US>
Bexarotene: D03106<JP/US>
Etretinate: D00316<JP>
Tazarotene: D01132<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    6257 (RXRB)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    6257 (RXRB)
   03320 PPAR signaling pathway
    6257 (RXRB)
   04919 Thyroid hormone signaling pathway
    6257 (RXRB)
   04928 Parathyroid hormone synthesis, secretion and action
    6257 (RXRB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6257 (RXRB)
   05202 Transcriptional misregulation in cancer
    6257 (RXRB)
   05207 Chemical carcinogenesis - receptor activation
    6257 (RXRB)
  09162 Cancer: specific types
   05226 Gastric cancer
    6257 (RXRB)
   05216 Thyroid cancer
    6257 (RXRB)
   05222 Small cell lung cancer
    6257 (RXRB)
   05223 Non-small cell lung cancer
    6257 (RXRB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    6257 (RXRB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6257 (RXRB)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    6257 (RXRB)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 hepatocyte nuclear factor 4-like
    6257 (RXRB)
Nuclear receptors [BR:hsa03310]
 2. Hepatocyte nuclear factor 4 like
  2B. Retinoid X receptor (RXR)
   6257 (RXRB)
SSDB
Motif
Pfam: Hormone_recep zf-C4 Nuc_recep-AF1
Other DBs
NCBI-GeneID: 6257
NCBI-ProteinID: NP_068811
OMIM: 180246
HGNC: 10478
Ensembl: ENSG00000204231
Pharos: P28702(Tclin)
UniProt: P28702 Q5STP9
Structure
Position
6:complement(33193588..33200853)
AA seq 533 aa
MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT
PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP
PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK
PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS
CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP
VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF
SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV
LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP
EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
NT seq 1602 nt   +upstreamnt  +downstreamnt
atgtcttgggccgctcgcccgcccttcctccctcagcggcatgccgcagggcagtgtggg
ccggtgggggtgcgaaaagaaatgcattgtggggtcgcgtcccggtggcggcggcgacgg
ccctggctggatcccgcagcggcggcggcggcggcggtggcaggcggagaacaacaaacc
ccggagccggagccaggggaggctggacgggacgggatgggcgacagcgggcgggactcc
cgaagcccagacagctcctccccaaatccccttccccagggagtccctcccccttctcct
cctgggccacccctacccccttcaacagctccatcccttggaggctctggggccccaccc
ccacccccgatgccaccacccccactgggctctccctttccagtcatcagttcttccatg
gggtcccctggtctgccccctccagctcccccaggattctccgggcctgtcagcagcccc
cagattaactcaacagtgtcactccctgggggtgggtctggcccccctgaagatgtgaag
ccaccagtcttaggggtccggggcctgcactgtccaccccctccaggtggccctggggct
ggcaaacggctatgtgcaatctgcggggacagaagctcaggcaaacactacggggtttac
agctgtgagggttgcaagggcttcttcaaacgcaccatccgcaaagaccttacatactct
tgccgggacaacaaagactgcacagtggacaagcgccagcggaaccgctgtcagtactgc
cgctatcagaagtgcctggccactggcatgaagagggaggcggtacaggaggagcgtcag
cggggaaaggacaaggatggggatggggagggggctgggggagcccccgaggagatgcct
gtggacaggatcctggaggcagagcttgctgtggaacagaagagtgaccagggcgttgag
ggtcctgggggaaccgggggtagcggcagcagcccaaatgaccctgtgactaacatctgt
caggcagctgacaaacagctattcacgcttgttgagtgggcgaagaggatcccacacttt
tcctccttgcctctggatgatcaggtcatattgctgcgggcaggctggaatgaactcctc
attgcctccttctcacaccgatccattgatgttcgagatggcatcctccttgccacaggt
cttcacgtgcaccgcaactcagcccattcagcaggagtaggagccatctttgatcgggtg
ctgacagagctagtgtccaaaatgcgtgacatgaggatggacaagacagagcttggctgc
ctgagggcaatcattctgtttaatccagatgccaagggcctctccaaccctagtgaggtg
gaggtcctgcgggagaaagtgtatgcatcactggagacctactgcaaacagaagtaccct
gagcagcagggacggtttgccaagctgctgctacgtcttcctgccctccggtccattggc
cttaagtgtctagagcatctgtttttcttcaagctcattggtgacacccccatcgacacc
ttcctcatggagatgcttgaggctccccatcaactggcctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (13)   
   KEGG PATHWAY (13)   
Network (4)   
   KEGG NETWORK (4)   
Disease (1)   
   OMIM (1)   
Drug (6)   
   KEGG DRUG (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (52)   
   RefSeq(nuc) (6)   
   GenBank (23)   
   EMBL (23)   
3D Structure (7)   
   PDB (7)   
Protein domain (3)   
   Pfam (3)   
All databases (130)   

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