KEGG   Homo sapiens (human): 627
Entry
627               CDS       T01001                                 
Symbol
BDNF, ANON2, BULN2
Name
(RefSeq) brain derived neurotrophic factor
  KO
K04355  brain-derived neurotrophic factor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05034  Alcoholism
Network
nt06461  Huntington disease
nt06526  MAPK signaling
nt06530  PI3K signaling
  Element
N00980  Mutation-caused aberrant Htt to REST-mediated transcriptional repression
N01592  GF-RTK-RAS-ERK signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    627 (BDNF)
   04014 Ras signaling pathway
    627 (BDNF)
   04024 cAMP signaling pathway
    627 (BDNF)
   04151 PI3K-Akt signaling pathway
    627 (BDNF)
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    627 (BDNF)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    627 (BDNF)
   05022 Pathways of neurodegeneration - multiple diseases
    627 (BDNF)
  09165 Substance dependence
   05030 Cocaine addiction
    627 (BDNF)
   05034 Alcoholism
    627 (BDNF)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    627 (BDNF)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Growth factors (RTK binding)
   627 (BDNF)
SSDB
Motif
Pfam: NGF NTF3_N Spaetzle
Other DBs
NCBI-GeneID: 627
NCBI-ProteinID: NP_001137277
OMIM: 113505
HGNC: 1033
Ensembl: ENSG00000176697
UniProt: P23560 A0A0E3SU01
Structure
Position
11:complement(27654893..27722030)
AA seq 247 aa
MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLA
DTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAA
NMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQY
FYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCT
LTIKRGR
NT seq 744 nt   +upstreamnt  +downstreamnt
atgaccatccttttccttactatggttatttcatactttggttgcatgaaggctgccccc
atgaaagaagcaaacatccgaggacaaggtggcttggcctacccaggtgtgcggacccat
gggactctggagagcgtgaatgggcccaaggcaggttcaagaggcttgacatcattggct
gacactttcgaacacgtgatagaagagctgttggatgaggaccagaaagttcggcccaat
gaagaaaacaataaggacgcagacttgtacacgtccagggtgatgctcagtagtcaagtg
cctttggagcctcctcttctctttctgctggaggaatacaaaaattacctagatgctgca
aacatgtccatgagggtccggcgccactctgaccctgcccgccgaggggagctgagcgtg
tgtgacagtattagtgagtgggtaacggcggcagacaaaaagactgcagtggacatgtcg
ggcgggacggtcacagtccttgaaaaggtccctgtatcaaaaggccaactgaagcaatac
ttctacgagaccaagtgcaatcccatgggttacacaaaagaaggctgcaggggcatagac
aaaaggcattggaactcccagtgccgaactacccagtcgtacgtgcgggcccttaccatg
gatagcaaaaagagaattggctggcgattcataaggatagacacttcttgtgtatgtaca
ttgaccattaaaaggggaagatag

  All links  
Disease (1)   
   OMIM (1)   
Gene (15)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (20)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (116)   
   RefSeq(nuc) (18)   
   GenBank (49)   
   EMBL (49)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   Pfam (3)   
All databases (157)   

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