KEGG   Homo sapiens (human): 6335Help
Entry
6335              CDS       T01001                                 

Gene name
SCN9A, ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA, Nav1.7, PN1, SFNP
Definition
(RefSeq) sodium voltage-gated channel alpha subunit 9
  KO
K04841  voltage-gated sodium channel type IX alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04742  Taste transduction
Disease
H00265  Hereditary sensory and autonomic neuropathy
H00771  Inherited erythromelalgia
H00772  Paroxysmal extreme pain disorder
H00774  Congenital insensitivity to pain
H00783  Febrile seizures
Drug target
Actisomide: D02762
Ajmaline: D00199
Aminobenzoic acid (DG00379): D02456 D02906 D02907
Amiodarone (DG00204): D00636 D02910
Aprindine (DG00199): D01326 D02969
Articaine (DG00805): D02991 D07468
Benzocaine: D00552
Bupivacaine (DG00801): D01450 D07552
Carbamazepine: D00252
Chloroprocaine (DG00800): D00732 D07678
Cibenzoline (DG00209): D01455 D03492
Cinchocaine (DG00297): D00733 D02220
Cocaine (DG00808): D00110 D02182
Disopyramide (DG00194): D00303 D00637
Eleclazine: D11155
Encainide (DG00203): D03991 D07894
Eslicarbazepine (DG00848): D09215 D09612
Ethyl piperidinoacetylaminobenzoate: D01519
Etidocaine (DG00804): D00737 D04095
Flecainide (DG00201): D00638 D07962
Fosphenytoin (DG00847): D02096 D07595 D07993
Funapide: D11156
Indecainide hydrochloride: D04521
Lacosamide: D07299
Lamotrigine: D00354
Levobupivacaine (DG00807): D01287 D08116
Levosemotiadil fumarate: D09833
Lidocaine (DG00196): D00358 D02086 D08127
Lorajmine: D04774
Mephenytoin: D00375
Mepivacaine (DG00802): D00738 D08181
Mexiletine (DG00197): D00639 D08215
Oxcarbazepine: D00533
Oxetacaine (DG00299): D01152 D08311
Oxybuprocaine (DG00392): D01768 D08319
Phenytoin (DG00846): D00512 D02103
Pilsicainide (DG01257): D01554 D08377
Pirmenol (DG01381): D01785 D06517 D08394
Pramocaine (DG00300): D00739 D08407
Prilocaine (DG00803): D00553 D01243
Procainamide (DG00193): D00477 D08421
Procaine (DG00298): D00740 D08422
Propafenone (DG00200): D00640 D08435
Proxymetacaine (DG01145): D02098 D08448
Quinidine (DG00192): D00642 D00643 D02272 D08458 D08459
Recainam (DG01421): D05708 D05709
Ropivacaine (DG00806): D04048 D08490
Rufinamide: D05775
Sparteine (DG00195): D01041 D02239
Tetracaine (DG00296): D00551 D00741
Tocainide (DG00198): D02088 D06172
Topiramate: D00537
Transcainide: D06203
Vixotrigine (DG02944): D11179 D11180
Zonisamide: D00538
p-Butylaminobenzoyldiethylaminoethyl hydrochloride: D01967
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09157 Sensory system
   04742 Taste transduction
    6335 (SCN9A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    6335 (SCN9A)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Sodium channel, voltage-gated (Nav)
   6335 (SCN9A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ion_trans Na_trans_cytopl Na_trans_assoc PKD_channel GPHH IQ Lustrin_cystein
Motif
Other DBs
NCBI-GeneID: 6335
NCBI-ProteinID: NP_002968
OMIM: 603415
HGNC: 10597
Ensembl: ENSG00000169432
Vega: OTTHUMG00000154044
Pharos: Q15858(Tclin)
UniProt: Q15858
Structure
PDB: 

Position
2q24.3
AA seq 1977 aa AA seqDB search
MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLP
FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI
KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE
FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR
KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQ
DYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKE
LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRR
KKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIR
GSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSS
NISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCS
SYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWI
KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEM
VLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPT
LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN
DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSF
SSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLN
TKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPI
APGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEP
EACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAF
EDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV
TLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF
WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDN
VGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNL
FIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDL
VTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRH
YYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIR
TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICL
FQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVV
VNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDP
PLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSAN
PSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKD
MAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK
NT seq 5934 nt NT seq  +upstreamnt  +downstreamnt
atggcaatgttgcctcccccaggacctcagagctttgtccatttcacaaaacagtctctt
gccctcattgaacaacgcattgctgaaagaaaatcaaaggaacccaaagaagaaaagaaa
gatgatgatgaagaagccccaaagccaagcagtgacttggaagctggcaaacagctgccc
ttcatctatggggacattcctcccggcatggtgtcagagcccctggaggacttggacccc
tactatgcagacaaaaagactttcatagtattgaacaaagggaaaacaatcttccgtttc
aatgccacacctgctttatatatgctttctcctttcagtcctctaagaagaatatctatt
aagattttagtacactccttattcagcatgctcatcatgtgcactattctgacaaactgc
atatttatgaccatgaataacccaccggactggaccaaaaatgtcgagtacacttttact
ggaatatatacttttgaatcacttgtaaaaatccttgcaagaggcttctgtgtaggagaa
ttcacttttcttcgtgacccgtggaactggctggattttgtcgtcattgtttttgcgtat
ttaacagaatttgtaaacctaggcaatgtttcagctcttcgaactttcagagtattgaga
gctttgaaaactatttctgtaatcccaggcctgaagacaattgtaggggctttgatccag
tcagtgaagaagctttctgatgtcatgatcctgactgtgttctgtctgagtgtgtttgca
ctaattggactacagctgttcatgggaaacctgaagcataaatgttttcgaaattcactt
gaaaataatgaaacattagaaagcataatgaataccctagagagtgaagaagactttaga
aaatatttttattacttggaaggatccaaagatgctctcctttgtggtttcagcacagat
tcaggtcagtgtccagaggggtacacctgtgtgaaaattggcagaaaccctgattatggc
tacacgagctttgacactttcagctgggccttcttagccttgtttaggctaatgacccaa
gattactgggaaaacctttaccaacagacgctgcgtgctgctggcaaaacctacatgatc
ttctttgtcgtagtgattttcctgggctccttttatctaataaacttgatcctggctgtg
gttgccatggcatatgaagaacagaaccaggcaaacattgaagaagctaaacagaaagaa
ttagaatttcaacagatgttagaccgtcttaaaaaagagcaagaagaagctgaggcaatt
gcagcggcagcggctgaatatacaagtattaggagaagcagaattatgggcctctcagag
agttcttctgaaacatccaaactgagctctaaaagtgctaaagaaagaagaaacagaaga
aagaaaaagaatcaaaagaagctctccagtggagaggaaaagggagatgctgagaaattg
tcgaaatcagaatcagaggacagcatcagaagaaaaagtttccaccttggtgtcgaaggg
cataggcgagcacatgaaaagaggttgtctacccccaatcagtcaccactcagcattcgt
ggctccttgttttctgcaaggcgaagcagcagaacaagtctttttagtttcaaaggcaga
ggaagagatataggatctgagactgaatttgccgatgatgagcacagcatttttggagac
aatgagagcagaaggggctcactgtttgtgccccacagaccccaggagcgacgcagcagt
aacatcagccaagccagtaggtccccaccaatgctgccggtgaacgggaaaatgcacagt
gctgtggactgcaacggtgtggtctccctggttgatggacgctcagccctcatgctcccc
aatggacagcttctgccagagggcacgaccaatcaaatacacaagaaaaggcgttgtagt
tcctatctcctttcagaggatatgctgaatgatcccaacctcagacagagagcaatgagt
agagcaagcatattaacaaacactgtggaagaacttgaagagtccagacaaaaatgtcca
ccttggtggtacagatttgcacacaaattcttgatctggaattgctctccatattggata
aaattcaaaaagtgtatctattttattgtaatggatccttttgtagatcttgcaattacc
atttgcatagttttaaacacattatttatggctatggaacaccacccaatgactgaggaa
ttcaaaaatgtacttgctataggaaatttggtctttactggaatctttgcagctgaaatg
gtattaaaactgattgccatggatccatatgagtatttccaagtaggctggaatattttt
gacagccttattgtgactttaagtttagtggagctctttctagcagatgtggaaggattg
tcagttctgcgatcattcagactgctccgagtcttcaagttggcaaaatcctggccaaca
ttgaacatgctgattaagatcattggtaactcagtaggggctctaggtaacctcacctta
gtgttggccatcatcgtcttcatttttgctgtggtcggcatgcagctctttggtaagagc
tacaaagaatgtgtctgcaagatcaatgatgactgtacgctcccacggtggcacatgaac
gacttcttccactccttcctgattgtgttccgcgtgctgtgtggagagtggatagagacc
atgtgggactgtatggaggtcgctggtcaagctatgtgccttattgtttacatgatggtc
atggtcattggaaacctggtggtcctaaacctatttctggccttattattgagctcattt
agttcagacaatcttacagcaattgaagaagaccctgatgcaaacaacctccagattgca
gtgactagaattaaaaagggaataaattatgtgaaacaaaccttacgtgaatttattcta
aaagcattttccaaaaagccaaagatttccagggagataagacaagcagaagatctgaat
actaagaaggaaaactatatttctaaccatacacttgctgaaatgagcaaaggtcacaat
ttcctcaaggaaaaagataaaatcagtggttttggaagcagcgtggacaaacacttgatg
gaagacagtgatggtcaatcatttattcacaatcccagcctcacagtgacagtgccaatt
gcacctggggaatccgatttggaaaatatgaatgctgaggaacttagcagtgattcggat
agtgaatacagcaaagtgagattaaaccggtcaagctcctcagagtgcagcacagttgat
aaccctttgcctggagaaggagaagaagcagaggctgaacctatgaattccgatgagcca
gaggcctgtttcacagatggttgtgtacggaggttctcatgctgccaagttaacatagag
tcagggaaaggaaaaatctggtggaacatcaggaaaacctgctacaagattgttgaacac
agttggtttgaaagcttcattgtcctcatgatcctgctcagcagtggtgccctggctttt
gaagatatttatattgaaaggaaaaagaccattaagattatcctggagtatgcagacaag
atcttcacttacatcttcattctggaaatgcttctaaaatggatagcatatggttataaa
acatatttcaccaatgcctggtgttggctggatttcctaattgttgatgtttctttggtt
actttagtggcaaacactcttggctactcagatcttggccccattaaatcccttcggaca
ctgagagctttaagacctctaagagccttatctagatttgaaggaatgagggtcgttgtg
aatgcactcataggagcaattccttccatcatgaatgtgctacttgtgtgtcttatattc
tggctgatattcagcatcatgggagtaaatttgtttgctggcaagttctatgagtgtatt
aacaccacagatgggtcacggtttcctgcaagtcaagttccaaatcgttccgaatgtttt
gcccttatgaatgttagtcaaaatgtgcgatggaaaaacctgaaagtgaactttgataat
gtcggacttggttacctatctctgcttcaagttgcaacttttaagggatggacgattatt
atgtatgcagcagtggattctgttaatgtagacaagcagcccaaatatgaatatagcctc
tacatgtatatttattttgtcgtctttatcatctttgggtcattcttcactttgaacttg
ttcattggtgtcatcatagataatttcaaccaacagaaaaagaagcttggaggtcaagac
atctttatgacagaagaacagaagaaatactataatgcaatgaaaaagctggggtccaag
aagccacaaaagccaattcctcgaccagggaacaaaatccaaggatgtatatttgaccta
gtgacaaatcaagcctttgatattagtatcatggttcttatctgtctcaacatggtaacc
atgatggtagaaaaggagggtcaaagtcaacatatgactgaagttttatattggataaat
gtggtttttataatccttttcactggagaatgtgtgctaaaactgatctccctcagacac
tactacttcactgtaggatggaatatttttgattttgtggttgtgattatctccattgta
ggtatgtttctagctgatttgattgaaacgtattttgtgtcccctaccctgttccgagtg
atccgtcttgccaggattggccgaatcctacgtctagtcaaaggagcaaaggggatccgc
acgctgctctttgctttgatgatgtcccttcctgcgttgtttaacatcggcctcctgctc
ttcctggtcatgttcatctacgccatctttggaatgtccaactttgcctatgttaaaaag
gaagatggaattaatgacatgttcaattttgagacctttggcaacagtatgatttgcctg
ttccaaattacaacctctgctggctgggatggattgctagcacctattcttaacagtaag
ccacccgactgtgacccaaaaaaagttcatcctggaagttcagttgaaggagactgtggt
aacccatctgttggaatattctactttgttagttatatcatcatatccttcctggttgtg
gtgaacatgtacattgcagtcatactggagaattttagtgttgccactgaagaaagtact
gaacctctgagtgaggatgactttgagatgttctatgaggtttgggagaagtttgatccc
gatgcgacccagtttatagagttctctaaactctctgattttgcagctgccctggatcct
cctcttctcatagcaaaacccaacaaagtccagctcattgccatggatctgcccatggtt
agtggtgaccggatccattgtcttgacatcttatttgcttttacaaagcgtgttttgggt
gagagtggggagatggattctcttcgttcacagatggaagaaaggttcatgtctgcaaat
ccttccaaagtgtcctatgaacccatcacaaccacactaaaacggaaacaagaggatgtg
tctgctactgtcattcagcgtgcttatagacgttaccgcttaaggcaaaatgtcaaaaat
atatcaagtatatacataaaagatggagacagagatgatgatttactcaataaaaaagat
atggcttttgataatgttaatgagaactcaagtccagaaaaaacagatgccacttcatcc
accacctctccaccttcatatgatagtgtaacaaagccagacaaagagaaatatgaacaa
gacagaacagaaaaggaagacaaagggaaagacagcaaggaaagcaaaaaatag

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