| Entry |
|
|---|
| Symbol |
SDHB, CWS2, IP, MC2DN4, PGL4, PPGL4, SDH, SDH1, SDH2, SDHIP
|
|---|
| Name |
(RefSeq) succinate dehydrogenase complex iron sulfur subunit B
|
|---|
| KO |
| K00235 | succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1] |
|
|---|
| Organism |
|
|---|
| Pathway |
| hsa04932 | Non-alcoholic fatty liver disease |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
|
|---|
| Module |
| hsa_M00011 | Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate |
|
|---|
| Network |
|
|---|
| Element |
| N00988 | Electron transfer in Complex II |
| N00989 | Mutation-caused aberrant Htt to electron transfer in Complex II |
| N01392 | Arsenic to electron transfer in complex II |
| N01393 | Arsenic to electron transfer in complex II |
| N01402 | Manganese to electron transfer in Complex II |
| N01617 | Citrate cycle, second carbon oxidation 2 |
| N01691 | mitochondrial complex - UCP1 in Thermogenesis |
|
|---|
| Disease |
| H01510 | Malignant paraganglioma |
| H01591 | Gastrotintestinal stromal tumor |
| H02005 | Mitochondrial complex II deficiency |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
6390 (SDHB)
09102 Energy metabolism
00190 Oxidative phosphorylation
6390 (SDHB)
09150 Organismal Systems
09159 Environmental adaptation
04714 Thermogenesis
6390 (SDHB)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
6390 (SDHB)
09164 Neurodegenerative disease
05010 Alzheimer disease
6390 (SDHB)
05012 Parkinson disease
6390 (SDHB)
05014 Amyotrophic lateral sclerosis
6390 (SDHB)
05016 Huntington disease
6390 (SDHB)
05020 Prion disease
6390 (SDHB)
05022 Pathways of neurodegeneration - multiple diseases
6390 (SDHB)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
6390 (SDHB)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
6390 (SDHB)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.5 With a quinone or related compound as acceptor
1.3.5.1 succinate dehydrogenase
6390 (SDHB)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| Structure |
|
|---|
| Position |
1:complement(17018722..17054032)
|
|---|
| AA seq |
280 aa
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQT
YEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN
LNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKL
DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL
YRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV |
|---|
| NT seq |
843 nt +upstreamnt +downstreamnt
atggcggcggtggtcgccctctccttgaggcgccggttgccggccacaacccttggcgga
gcctgcctgcaggcctcccgaggagcccagacagctgcagccacagctccccgtatcaag
aaatttgccatctatcgatgggacccagacaaggctggagacaaacctcatatgcagact
tatgaagttgaccttaataaatgtggccccatggtattggatgctttaatcaagattaag
aatgaagttgactctactttgaccttccgaagatcatgcagagaaggcatctgtggctct
tgtgcaatgaacatcaatggaggcaacactctagcttgcacccgaaggattgacaccaac
ctcaataaggtctcaaaaatctaccctcttccacacatgtatgtgataaaggatcttgtt
cccgatttgagcaacttctatgcacagtacaaatccattgagccttatttgaagaagaag
gatgaatctcaggaaggcaagcagcagtatctgcagtccatagaagagcgtgagaaactg
gacgggctctacgagtgcattctctgtgcctgctgtagcaccagctgccccagctactgg
tggaacggagacaaatatctggggcctgcagttcttatgcaggcctatcgctggatgatt
gactccagagatgacttcacagaggagcgcctggccaagctgcaggacccattctctcta
taccgctgccacaccatcatgaactgcacaaggacctgtcctaagggtctgaatccaggg
aaagctattgcagagatcaagaaaatgatggcaacctataaggagaagaaagcttcagtt
taa |
|---|
