KEGG   Homo sapiens (human): 63916
Entry
63916             CDS       T01001                                 

Gene name
ELMO2, CED-12, CED12, Ced-12A, ELMO-2, VMPI
Definition
(RefSeq) engulfment and cell motility 2
  KO
K18985  engulfment and cell motility protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
Network
nt06135  Cytoskeletal regulation (viruses)
  Element
N00951  ITGA/B-RHOG-RAC signaling pathway
N00952  Shigella IpgB1 to ITGA/B-RHOG-RAC signaling pathway
N01132  Salmonella SopE/E2 to RhoG signaling pathway
N01133  Salmonella SopB to RhoG signaling pathway
Disease
H02088  Primary intraosseous vascular malformation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    63916 (ELMO2)
   05131 Shigellosis
    63916 (ELMO2)
   05135 Yersinia infection
    63916 (ELMO2)
   05100 Bacterial invasion of epithelial cells
    63916 (ELMO2)
SSDB
Motif
Pfam: DUF3361 ELMO_CED12 PH_12
Other DBs
NCBI-GeneID: 63916
NCBI-ProteinID: NP_573403
OMIM: 606421
HGNC: 17233
Ensembl: ENSG00000062598
Vega: OTTHUMG00000033070
Pharos: Q96JJ3(Tbio)
UniProt: Q96JJ3
Structure
PDB: 
6IDX 6IE1

Position
20q13.12
AA seq 720 aa
MPPPSDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLRYADGPQLY
ITEQTRSDIKNGTILQLAISPSRAARQLMERTQSSNMETRLDAMKELAKLSADVTFATEF
INMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVSITFIKQIAGYV
SQPMVDVSILQRSLAILESMVLNSQSLYQKIAEEITVGQLISHLQVSNQEIQTYAIALIN
ALFLKAPEDKRQDMANAFAQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEER
MMTKMDPNDQAQRDIIFELRRIAFDAESDPSNAPGSGTEKRKAMYTKDYKMLGFTNHINP
AMDFTQTPPGMLALDNMLYLAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEI
LQVGELPNEGRNDYHPMFFTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQ
ITRALPSKPNSLDQFKSKLRSLSYSEILRLRQSERMSQDDFQSPPIVELREKIQPEILEL
IKQQRLNRLCEGSSFRKIGNRRRQERFWYCRLALNHKVLHYGDLDDNPQGEVTFESLQEK
IPVADIKAIVTGKDCPHMKEKSALKQNKEVLELAFSILYDPDETLNFIAPNKYEYCIWID
GLSALLGKDMSSELTKSDLDTLLSMEMKLRLLDLENIQIPEAPPPIPKEPSSYDFVYHYG
NT seq 2163 nt   +upstreamnt  +downstreamnt
atgccaccaccgtcagacattgtcaaagtggccattgagtggccaggtgctaacgcccag
ctccttgaaatcgaccagaaacggcccctggcatccattatcaaggaagtttgtgatggg
tggtcgttgccaaacccagagtattataccctccgttatgcagatggtcctcagctgtac
atcaccgaacagactcgcagtgacattaagaatgggacaatcttacaactggctatctcc
ccgtcccgggctgcacgccagctgatggagaggacccagtcatccaacatggagacccgg
ctggatgccatgaaggagctggccaagctctctgccgacgtgactttcgctactgagttc
atcaacatggatggcatcattgtgctgacaaggctcgtggaaagtggaaccaagctcttg
tcccactacagtgagatgctggcattcaccctgactgccttcctagagctcatggaccat
ggcattgtctcctgggacatggtttcaatcacctttattaagcagattgcagggtatgtg
agccagcccatggtggacgtgtcaatccttcagaggtccctggccatcctggagagcatg
gtcttgaacagccagagtctgtaccagaagatagccgaggaaatcaccgtgggacagctc
atctcacacctccaggtctccaaccaggagattcagacctacgccattgcactgattaat
gcactttttctgaaggctcctgaggacaaacgacaggatatggcaaatgcatttgcacag
aagcatctccggtctataatcctgaatcatgtgatccgagggaaccgccccatcaaaact
gagatggcccatcagctatatgtccttcaagtcctaacctttaaccttctggaagaaagg
atgatgaccaagatggaccccaatgaccaggctcaaagggacatcatatttgaactgagg
aggattgcatttgacgcagagtctgatcctagcaatgcccctgggagtgggaccgaaaaa
cgcaaagccatgtacacaaaggactacaaaatgctgggatttaccaaccacatcaatcca
gccatggactttacccagactcctcctggaatgctggccttggacaacatgctgtacttg
gctaaagtccaccaggacacctacatccggattgtcttggagaacagtagccgggaagac
aaacatgaatgcccctttggccgcagtgccattgagctcaccaaaatgctctgtgaaatc
ctgcaggttggggaactaccaaatgaaggacgcaatgactaccacccgatgttctttacc
catgaccgagcctttgaagagctctttggaatctgcatccagctgttgaacaagacctgg
aaggagatgagggcaacagcagaggacttcaacaaggttatgcaagtcgtccgagagcaa
atcactcgagctttgccctccaaacccaactctttggatcagttcaagagcaaattgcgt
agcctgagttactctgagattctacgactgcgccagtctgagaggatgagtcaggatgac
ttccagtccccgccaattgtggagctgagggagaagatccagcccgagatccttgagctg
atcaagcagcagcgcctgaaccggctctgtgagggcagcagcttccgaaagattgggaac
cgccgaaggcaagaacggttctggtactgccggttggcactgaaccacaaggtccttcac
tatggtgacttggatgacaacccacaaggggaggtgacatttgaatccctgcaggagaaa
attcctgttgcagacattaaggccattgtcactgggaaagattgtccccacatgaaagag
aaaagtgctctgaaacagaacaaggaggtgttggaattggccttctccatcctgtatgac
cctgatgagaccttaaacttcatcgcacctaataaatatgagtactgcatctggattgat
ggcctcagtgcccttctggggaaggacatgtccagtgagctgaccaagagtgacctggac
accctgctgagcatggagatgaagctgcggctcctggacctggagaacatccagattccc
gaagccccaccccccatccccaaggagcccagcagctatgactttgtctatcactatggc
tga

KEGG   Homo sapiens (human): 79767
Entry
79767             CDS       T01001                                 

Gene name
ELMO3, CED-12, CED12, ELMO-3
Definition
(RefSeq) engulfment and cell motility 3
  KO
K19241  engulfment and cell motility protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa05100  Bacterial invasion of epithelial cells
Network
nt06135  Cytoskeletal regulation (viruses)
  Element
N00951  ITGA/B-RHOG-RAC signaling pathway
N00952  Shigella IpgB1 to ITGA/B-RHOG-RAC signaling pathway
N01132  Salmonella SopE/E2 to RhoG signaling pathway
N01133  Salmonella SopB to RhoG signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    79767 (ELMO3)
SSDB
Motif
Pfam: DUF3361 ELMO_CED12 PH_12 DnaB_bind
Other DBs
NCBI-GeneID: 79767
NCBI-ProteinID: NP_078988
OMIM: 606422
HGNC: 17289
Ensembl: ENSG00000102890
Vega: OTTHUMG00000133570
Pharos: Q96BJ8(Tbio)
UniProt: Q96BJ8
Position
16q22.1
AA seq 720 aa
MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRY
ITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREV
ISRNGLQILGTIIEDGDDLGEVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNL
MDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQ
GASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTP
LDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFSNSNPAQDLER
VPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEP
CSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLA
LKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRL
LRLCEGTLFRKISSRRRQDKLWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMR
ALLTGKDCPHVREKGSGKQNKDLYELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSA
LLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP
NT seq 2163 nt   +upstreamnt  +downstreamnt
atggcgcctccgcggaacgtggtgaagattgccatcaagatgcgtgacgccatcccgcag
ctcatccagctggaccaggcgaagcccctggccgctgtgctgaaggaggtgtgcgacgcg
tggagcctgacgcactctgagcgttacgccctgcagtttgcggatgggcaccggagatac
atcaccgagaataaccgcgcggagatcaagaatggcagcatcctgtgcctcagcacggcc
ccagaccttgaggctgagcagctcttgggtgggctgcagagtaacagtcctgaagggcgc
cgggaagccctgaggcgccttgttccgctggcctcggacatgatctttgccagggaggtc
atcagccgtaatgggctccagatactaggcaccatcattgaagatggggacgacctagga
gaggtgctggccctcagcctgagggccttctcagagctcatggagcacggcgtggtgtcc
tgggagactctgagcatcccctttgtgaggaaggtggtgtgctacgtgaacatgaacctc
atggatgcctccgtgcctcccctggcccttgggctgctggagagtgtgaccttgagcagc
ccagccctgggccagctggtcaagagcgaggtgcccctggataggctgctggtgcaccta
caggtgatgaaccagcagctgcaaaccaaggccatggccctgctgacagccttgctgcag
ggggccagccctgtggaacgcaagcacatgcttgactatctttggcagaggaaccttcgc
cagttcatctataagaacatcatccacagtgcagcaccaatgggcgacgagatggctcat
cacctgtacgtactgcaggctctcatgctggggctgctggagccgcgcatgcggacgccc
ctggacccctacagccaggagcagcgggagcagctgcaggtcctacgccaggctgccttc
gaggtggagggggagtcctcgggtgccgggctaagtgctgaccgtcgccgttccctctgt
gcccgagagttccgcaaactgggcttttctaacagcaacccagcacaggacctggagcgc
gtgccccccggtctgctggccctggacaacatgttgtacttctccagaaacgcgcccagc
gcgtacagccggtttgtgttggagaacagcagccgcgaggacaagcacgagtgccccttt
gcccggggcagcatccagctgacggtgctgctgtgtgagctgctccgtgttggggagccc
tgctctgagacagcccaggacttctcacccatgttcttcggccaagaccagagcttccac
gagctcttctgtgtgggcatccagctgttgaataagacctggaaggagatgcgggctaca
caggaggacttcgacaaggtcatgcaggtggtgcgggagcagctggcccgcactctggcc
ctgaagcccacttccctggagctcttccgaaccaaggtgaatgcgctcacttatggggag
gtgctgcggctgcggcagactgaacggctgcaccaggagggcacactggctccccctata
ctggagctgcgggagaagctgaagccagagctcatgggcctgatccgccagcagcgcttg
ctccgcctctgtgaggggacgctcttccgcaagatcagcagccggcggcgccaggataag
ctgtggttctgctgcctgtcccccaaccacaagctgctgcagtacggagacatggaggag
ggcgccagcccgcctaccctggagagtctgcccgagcaactccctgtggccgacatgagg
gcactcctgacaggcaaggactgcccccatgtccgggagaagggctccgggaagcagaac
aaggacctctatgagttggccttctcaatcagctatgaccgtggggaggaggaagcgtac
ctcaacttcattgccccctccaagcgggagttctacctgtggacagatgggctcagtgcc
ttgctgggcagtcccatgggcagcgagcagacacggctggacctggagcagctgctgacc
atggagaccaagctgcgtctgctggagctggagaacgtgcccatccccgagcggccaccc
cctgtgcccccaccccccaccaacttcaacttctgctatgactgcagcatcgctgaacct
tga

KEGG   Homo sapiens (human): 9844
Entry
9844              CDS       T01001                                 

Gene name
ELMO1, CED-12, CED12, ELMO-1
Definition
(RefSeq) engulfment and cell motility 1
  KO
K12366  engulfment and cell motility protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
Network
nt06135  Cytoskeletal regulation (viruses)
  Element
N00951  ITGA/B-RHOG-RAC signaling pathway
N00952  Shigella IpgB1 to ITGA/B-RHOG-RAC signaling pathway
N01068  ITGA/B-FAK-RAC signaling pathway
N01132  Salmonella SopE/E2 to RhoG signaling pathway
N01133  Salmonella SopB to RhoG signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    9844 (ELMO1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    9844 (ELMO1)
   05131 Shigellosis
    9844 (ELMO1)
   05135 Yersinia infection
    9844 (ELMO1)
   05100 Bacterial invasion of epithelial cells
    9844 (ELMO1)
SSDB
Motif
Pfam: DUF3361 ELMO_CED12 PH_12 FERM_N Imm42 ZFYVE21_C
Other DBs
NCBI-GeneID: 9844
NCBI-ProteinID: NP_001193409
OMIM: 606420
HGNC: 16286
Ensembl: ENSG00000155849
Vega: OTTHUMG00000023701
Pharos: Q92556(Tbio)
UniProt: Q92556 A4D1X5
Structure
PDB: 
3A98 2VSZ

Position
7p14.2-p14.1
AA seq 727 aa
MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFY
ITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEF
INLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAF
IKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQ
TYTIAVINALFLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVL
TFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLG
FINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIEL
TKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKV
MQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKI
QPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVP
HDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKH
EYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNY
DFVYDCN
NT seq 2184 nt   +upstreamnt  +downstreamnt
atgccgccacccgcggacatcgtcaaggtggccatagaatggccgggcgcctaccccaaa
ctcatggaaattgatcagaaaaaaccactgtctgcaataataaaggaagtctgtgatggg
tggtctcttgccaaccatgaatattttgcactccagcatgccgatagttcaaacttctat
atcacagaaaagaaccgcaatgagataaaaaatggcactatccttcgattaaccacatct
ccagctcagaacgcccagcagctccatgaacgaatccagtcctcgagtatggatgccaag
ctggaagccctgaaggacttggccagcctctcccgggatgtcacgtttgcccaggagttt
ataaacctggacggtatctctctcctcacgcagatggtggagagcggcactgagcgatac
cagaaattgcagaagatcatgaagccttgctttggagacatgctgtccttcaccctgacg
gccttcgttgagctgatggaccatggcatagtgtcctgggatacattttcggtggcgttc
attaagaagatagcaagttttgtgaacaagtcagccatagacatctcgatcctgcagcgg
tccttggccattttggagtcgatggtgctcaatagccatgacctctaccagaaagtggcg
caggagatcaccatcggccagctcattccacacctgcaagggtcagatcaagaaatccaa
acctatactattgcagtgattaatgcgcttttcctgaaggctcctgatgagaggaggcag
gagatggcgaatattttggctcagaagcaactgcgttccatcattttaacacatgtcatc
cgagcccagcgggccatcaacaatgagatggcgcaccagctgtatgttctacaagtgctc
acctttaacctcctggaagacaggatgatgaccaaaatggacccccaggaccaggctcag
agggacatcatatttgaacttcgaagaattgcttttgatgctgagtctgaacctaacaac
agcagtggcagcatggagaaacgcaagtccatgtacacgcgagattataagaagcttggg
ttcattaatcatgtcaaccctgccatggacttcacgcagactccacctgggatgttggct
ctggacaacatgctgtactttgccaagcaccaccaagatgcctacatccggattgtgctt
gagaacagtagtcgagaagacaagcatgaatgtccctttggccgcagtagtatagagctg
accaagatgctatgtgagatcttgaaagtgggcgagttgcctagtgagacctgcaacgac
ttccacccgatgttcttcacccacgacagatcctttgaggagtttttctgcatctgtatc
cagctcctgaacaagacatggaaggaaatgagggcaacttctgaagacttcaacaaggta
atgcaggtggtgaaggagcaggttatgagagcacttacaaccaagcctagctccctggac
cagttcaagagcaaactgcagaacctgagctacactgagatcctgaaaatccgccagtcc
gagaggatgaaccaggaagatttccagtcccgcccgattttggaactaaaggagaagatt
cagccagaaatcttagagctgatcaaacagcaacgcctgaaccgccttgtggaagggacc
tgctttaggaaactcaatgcccggcggaggcaagacaagttttggtattgtcggctttcg
ccaaatcacaaagtcctgcattacggagacttagaagagagtcctcagggagaagtgccc
cacgattccttgcaggacaaactgccggtggcagatatcaaagccgtggtgacgggaaag
gactgccctcatatgaaagagaaaggtgcccttaaacaaaacaaggaggtgcttgaactc
gctttctccatcttgtatgactcaaactgccaactgaacttcatcgctcctgacaagcat
gagtactgtatctggacggatggactgaatgcgctactcgggaaggacatgatgagcgac
ctgacgcggaatgacctggacaccctgctcagcatggaaatcaagctccgcctcctggac
ctggaaaacatccagatccctgacgcacctccgccgattcccaaggagcccagcaactat
gacttcgtctatgactgtaactga

DBGET integrated database retrieval system