KEGG   Homo sapiens (human): 64109
Entry
64109             CDS       T01001                                 
Symbol
CRLF2, CRL2, CRLF2Y, TSLPR
Name
(RefSeq) cytokine receptor-like factor 2 isoform 1 precursor
  KO
K05078  thymic stromal-derived lymphopoietin receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Network
nt06518  JAK-STAT signaling
  Element
N01554  IL2 family to Jak-STAT signaling pathway
Disease
H00001  B-cell acute lymphoblastic leukemia
Drug target
Solrikitug: D13085
Verekitug: D12973
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    64109 (CRLF2)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    64109 (CRLF2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    64109 (CRLF2)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL2 receptor family
   64109 (CRLF2)
SSDB
Motif
Pfam: CRLF2-like_D2 TSLPR_D1 CRLF2_D1 fn3 Fn3_ROS1 Tissue_fac C1-set IL6Ra-bind Interfer-bind Pur_ac_phosph_N
Other DBs
NCBI-GeneID: 64109
NCBI-ProteinID: NP_071431
OMIM: 400023
HGNC: 14281
Ensembl: ENSP00000383641.3
UniProt: Q9HC73 D0E2W4
Structure
Position
X:complement(1190490..1212649)
AA seq 371 aa
MGRLVLLWGAAVFLLGGWMALGQGGAAEGVQIQIIYFNLETVQVTWNASKYSRTNLTFHY
RFNGDEAYDQCTNYLLQEGHTSGCLLDAEQRDDILYFSIRNGTHPVFTASRWMVYYLKPS
SPKHVRFSWHQDAVTVTCSDLSYGDLLYEVQYRSPFDTEWQSKQENTCNVTIEGLDAEKC
YSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSKFILISSLAI
LLMVSLLLLSLWKLWRVKKFLIPSVPDPKSIFPGLFEIHQGNFQEWITDTQNVAHLHKMA
GAEQESGPEEPLVVQLAKTEAESPRMLDPQTEEKEASGGSLQLPHQPLQGGDVVTIGGFT
FVMNDRSYVAL
NT seq 1116 nt   +upstreamnt  +downstreamnt
atggggcggctggttctgctgtggggagctgccgtctttctgctgggaggctggatggct
ttggggcaaggaggagcagcagaaggagtacagattcagatcatctacttcaatttagaa
accgtgcaggtgacatggaatgccagcaaatactccaggaccaacctgactttccactac
agattcaacggtgatgaggcctatgaccagtgcaccaactaccttctccaggaaggtcac
acttcggggtgcctcctagacgcagagcagcgagacgacattctctatttctccatcagg
aatgggacgcaccccgttttcaccgcaagtcgctggatggtttattacctgaaacccagt
tccccgaagcacgtgagattttcgtggcatcaggatgcagtgacggtgacgtgttctgac
ctgtcctacggggatctcctctatgaggttcagtaccggagccccttcgacaccgagtgg
cagtccaaacaggaaaatacctgcaacgtcaccatagaaggcttggatgccgagaagtgt
tactctttctgggtcagggtgaaggctatggaggatgtatatgggccagacacataccca
agcgactggtcagaggtgacatgctggcagagaggcgagattcgggatgcctgtgcagag
acaccaacgcctcccaaaccaaagctgtccaaatttattttaatttccagcctggccatc
cttctgatggtgtctctcctccttctgtctttatggaaattatggagagtgaagaagttt
ctcattcccagcgtgccagacccgaaatccatcttccccgggctctttgagatacaccaa
gggaacttccaggagtggatcacagacacccagaacgtggcccacctccacaagatggca
ggtgcagagcaagaaagtggccccgaggagcccctggtagtccagttggccaagactgaa
gccgagtctcccaggatgctggacccacagaccgaggagaaagaggcctctgggggatcc
ctccagcttccccaccagcccctccaaggcggtgatgtggtcacaatcgggggcttcacc
tttgtgatgaatgaccgctcctacgtggcgttgtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (8)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (21)   
   RefSeq(nuc) (7)   
   GenBank (7)   
   EMBL (7)   
3D Structure (2)   
   PDB (2)   
Protein domain (10)   
   Pfam (10)   
All databases (52)   

Download RDF
DBGET integrated database retrieval system