KEGG   Homo sapiens (human): 64223
Entry
64223             CDS       T01001                                 
Symbol
MLST8, GBL, GbetaL, LST8, POP3, WAT1
Name
(RefSeq) MTOR associated protein, LST8 homolog
  KO
K08266  target of rapamycin complex subunit LST8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04714  Thermogenesis
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06522  mTOR signaling
nt06532  Autophagy
  Element
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N01575  TSC1/2-mTORC1 signaling pathway
N01578  GATOR1-mTORC1 signaling pathway
N01584  FLCN-mTORC1 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    64223 (MLST8)
   04150 mTOR signaling pathway
    64223 (MLST8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    64223 (MLST8)
   04136 Autophagy - other
    64223 (MLST8)
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    64223 (MLST8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    64223 (MLST8)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    64223 (MLST8)
   mTORC2 complex
    64223 (MLST8)
SSDB
Motif
Pfam: WD40 WD40_Prp19 Beta-prop_EML_2 WD40_CDC20-Fz WD40_WDHD1_1st WDR55 EIF3I Beta-prop_WDR90_POC16_2nd Beta-prop_TEP1_2nd Beta-prop_EML Beta-prop_CAF1B_HIR1 Beta-prop_TEP1_C WD40_MABP1-WDR62_1st WD40_MABP1-WDR62_2nd ANAPC4_WD40 WDR90_beta-prop_4th Beta-prop_DCAF4 Beta-prop_HPS5 Beta-prop_EIPR1 Beta-prop_IFT140_1st Beta-prop_RIG_2nd Beta-prop_WDR19_1st Beta-prop_WDR75_1st Beta-prop_Nup120_160 Beta-prop_Vps41 WD40_RFWD3 Beta-prop_IFT122_1st Beta-prop_SPT8 Beta-prop_NWD2_C TAF1C_beta-prop Beta-prop_NUP159_NUP214 Hira Beta-prop_IFT122_2nd PEP5_VPS11_N Beta-prop_SCAP Beta-prop_WDR75_2nd DUF5854
Other DBs
NCBI-GeneID: 64223
NCBI-ProteinID: NP_001186102
OMIM: 612190
HGNC: 24825
Ensembl: ENSG00000167965
UniProt: Q9BVC4
Structure
Position
16:2205454..2209453
AA seq 326 aa
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG
NT seq 981 nt   +upstreamnt  +downstreamnt
atgaacacctccccaggcacggtgggcagtgacccggtcatcctggccactgcaggctac
gaccacaccgtgcgcttctggcaggcccacagcggcatctgcacccggacggtgcagcac
caggactcccaggtgaatgccttggaggtcacaccggaccgcagcatgattgctgctgca
ggttaccagcacatccgcatgtatgatctcaactccaataaccctaaccccatcatcagc
tacgacggcgtcaacaagaacatcgcgtctgtgggcttccacgaagacggccgctggatg
tacacgggcggcgaggactgcacagccaggatctgggacctcaggtcccggaacctgcag
tgccagcggatcttccaggtgaacgcacccattaactgcgtgtgcctgcaccccaaccag
gcagagctcatcgtgggtgaccagagcggggctatccacatctgggacttgaaaacagac
cacaacgagcagctgatccctgagcccgaggtctccatcacgtccgcccacatcgatccc
gacgccagctacatggcagctgtcaatagcaccggaaactgctatgtctggaatctgacg
gggggcattggtgacgaggtgacccagctcatccccaagactaagatccctgcccacacg
cgctacgccctgcagtgtcgcttcagccccgactccacgctcctcgccacctgctcggct
gatcagacgtgcaagatctggaggacgtccaacttctccctgatgacggagctgagcatc
aagagcggcaaccccggggagtcctcccgcggctggatgtggggctgcgccttctcgggg
gactcccagtacatcgtcactgcttcctcggacaacctggcccggctctggtgtgtggag
actggagagatcaagagagagtatggcggccaccagaaggctgttgtctgcctggccttc
aatgacagtgtgctgggctag

  All links  
Disease (1)   
   OMIM (1)   
Gene (13)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (19)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (61)   
   RefSeq(nuc) (21)   
   GenBank (20)   
   EMBL (20)   
3D Structure (32)   
   PDB (32)   
Protein domain (37)   
   Pfam (37)   
All databases (163)   

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