KEGG   Homo sapiens (human): 6446
Entry
6446              CDS       T01001                                 
Symbol
SGK1, SGK
Name
(RefSeq) serum/glucocorticoid regulated kinase 1
  KO
K13302  serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04148  Efferocytosis
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04960  Aldosterone-regulated sodium reabsorption
Network
nt06325  Hormone/cytokine signaling
nt06535  Efferocytosis
  Element
N01784  Glucose uptake and lactate release induced by efferocytosis
N01823  FGF23-NCC/NPT signaling pathway
N01824  SGK1-NHERF1+NPT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    6446 (SGK1)
   04151 PI3K-Akt signaling pathway
    6446 (SGK1)
   04150 mTOR signaling pathway
    6446 (SGK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    6446 (SGK1)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    6446 (SGK1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    6446 (SGK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6446 (SGK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6446 (SGK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  SGK family [OT]
   6446 (SGK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like ABC1 PX Kdo
Other DBs
NCBI-GeneID: 6446
NCBI-ProteinID: NP_005618
OMIM: 602958
HGNC: 10810
Ensembl: ENSG00000118515
UniProt: O00141
Structure
Position
6:complement(134169256..134318112)
AA seq 431 aa
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
NT seq 1296 nt   +upstreamnt  +downstreamnt
atgacggtgaaaactgaggctgctaagggcaccctcacttactccaggatgaggggcatg
gtggcaattctcatcgctttcatgaagcagaggaggatgggtctgaacgactttattcag
aagattgccaataactcctatgcatgcaaacaccctgaagttcagtccatcttgaagatc
tcccaacctcaggagcctgagcttatgaatgccaacccttctcctccaccaagtccttct
cagcaaatcaaccttggcccgtcgtccaatcctcatgctaaaccatctgactttcacttc
ttgaaagtgatcggaaagggcagttttggaaaggttcttctagcaagacacaaggcagaa
gaagtgttctatgcagtcaaagttttacagaagaaagcaatcctgaaaaagaaagaggag
aagcatattatgtcggagcggaatgttctgttgaagaatgtgaagcaccctttcctggtg
ggccttcacttctctttccagactgctgacaaattgtactttgtcctagactacattaat
ggtggagagttgttctaccatctccagagggaacgctgcttcctggaaccacgggctcgt
ttctatgctgctgaaatagccagtgccttgggctacctgcattcactgaacatcgtttat
agagacttaaaaccagagaatattttgctagattcacagggacacattgtccttactgac
ttcggactctgcaaggagaacattgaacacaacagcacaacatccaccttctgtggcacg
ccggagtatctcgcacctgaggtgcttcataagcagccttatgacaggactgtggactgg
tggtgcctgggagctgtcttgtatgagatgctgtatggcctgccgcctttttatagccga
aacacagctgaaatgtacgacaacattctgaacaagcctctccagctgaaaccaaatatt
acaaattccgcaagacacctcctggagggcctcctgcagaaggacaggacaaagcggctc
ggggccaaggatgacttcatggagattaagagtcatgtcttcttctccttaattaactgg
gatgatctcattaataagaagattactcccccttttaacccaaatgtgagtgggcccaac
gacctacggcactttgaccccgagtttaccgaagagcctgtccccaactccattggcaag
tcccctgacagcgtcctcgtcacagccagcgtcaaggaagctgccgaggctttcctaggc
ttttcctatgcgcctcccacggactctttcctctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (18)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (49)   
   RefSeq(nuc) (5)   
   GenBank (22)   
   EMBL (22)   
3D Structure (4)   
   PDB (4)   
Protein domain (7)   
   Pfam (7)   
All databases (86)   

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