KEGG   Homo sapiens (human): 6446
Entry
6446              CDS       T01001                                 

Gene name
SGK1, SGK
Definition
(RefSeq) serum/glucocorticoid regulated kinase 1
  KO
K13302  serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04960  Aldosterone-regulated sodium reabsorption
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    6446 (SGK1)
   04151 PI3K-Akt signaling pathway
    6446 (SGK1)
   04150 mTOR signaling pathway
    6446 (SGK1)
 09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    6446 (SGK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6446 (SGK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6446 (SGK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  SGK family [OT]
   6446 (SGK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like Pkinase_C Kdo PX APH
Other DBs
NCBI-GeneID: 6446
NCBI-ProteinID: NP_005618
OMIM: 602958
HGNC: 10810
Ensembl: ENSG00000118515
Vega: OTTHUMG00000015613
Pharos: O00141(Tchem)
UniProt: O00141
Structure
PDB: 
2R5T 3HDM 3HDN

Position
6q23.2
AA seq 431 aa
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
NT seq 1296 nt   +upstreamnt  +downstreamnt
atgacggtgaaaactgaggctgctaagggcaccctcacttactccaggatgaggggcatg
gtggcaattctcatcgctttcatgaagcagaggaggatgggtctgaacgactttattcag
aagattgccaataactcctatgcatgcaaacaccctgaagttcagtccatcttgaagatc
tcccaacctcaggagcctgagcttatgaatgccaacccttctcctccaccaagtccttct
cagcaaatcaaccttggcccgtcgtccaatcctcatgctaaaccatctgactttcacttc
ttgaaagtgatcggaaagggcagttttggaaaggttcttctagcaagacacaaggcagaa
gaagtgttctatgcagtcaaagttttacagaagaaagcaatcctgaaaaagaaagaggag
aagcatattatgtcggagcggaatgttctgttgaagaatgtgaagcaccctttcctggtg
ggccttcacttctctttccagactgctgacaaattgtactttgtcctagactacattaat
ggtggagagttgttctaccatctccagagggaacgctgcttcctggaaccacgggctcgt
ttctatgctgctgaaatagccagtgccttgggctacctgcattcactgaacatcgtttat
agagacttaaaaccagagaatattttgctagattcacagggacacattgtccttactgac
ttcggactctgcaaggagaacattgaacacaacagcacaacatccaccttctgtggcacg
ccggagtatctcgcacctgaggtgcttcataagcagccttatgacaggactgtggactgg
tggtgcctgggagctgtcttgtatgagatgctgtatggcctgccgcctttttatagccga
aacacagctgaaatgtacgacaacattctgaacaagcctctccagctgaaaccaaatatt
acaaattccgcaagacacctcctggagggcctcctgcagaaggacaggacaaagcggctc
ggggccaaggatgacttcatggagattaagagtcatgtcttcttctccttaattaactgg
gatgatctcattaataagaagattactcccccttttaacccaaatgtgagtgggcccaac
gacctacggcactttgaccccgagtttaccgaagagcctgtccccaactccattggcaag
tcccctgacagcgtcctcgtcacagccagcgtcaaggaagctgccgaggctttcctaggc
ttttcctatgcgcctcccacggactctttcctctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (50)   
   RefSeq(nuc) (6)   
   GenBank (22)   
   EMBL (22)   
Protein domain (7)   
   Pfam (7)   
All databases (96)   

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