| Entry |
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| Symbol |
SHMT2, GLYA, HEL-S-51e, NEDCASB, SHMT, mSHMT
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| Name |
(RefSeq) serine hydroxymethyltransferase 2
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| KO |
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| Organism |
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| Pathway |
| hsa00260 | Glycine, serine and threonine metabolism |
| hsa00630 | Glyoxylate and dicarboxylate metabolism |
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| Module |
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| Network |
nt06030 Methionine metabolism nt06033 Glycine, serine and arginine metabolism |
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| Element |
| N01629 | Remethylation, THF to 5-MTHF |
| N01791 | Glycine metabolism, Ser to Gly |
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| Disease |
| H02470 | Neurodevelopmental disorder with structural brain abnormalities |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09101 Carbohydrate metabolism
00630 Glyoxylate and dicarboxylate metabolism
6472 (SHMT2)
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
6472 (SHMT2)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
6472 (SHMT2)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
6472 (SHMT2)
Enzymes [BR:hsa01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.1 glycine hydroxymethyltransferase
6472 (SHMT2)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
12:57229711..57234935
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| AA seq |
504 aa
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL
QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ
RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV
CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD
PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA
MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT
PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ
RLANLRQRVEQFARAFPMPGFDEH |
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| NT seq |
1515 nt +upstreamnt +downstreamnt
atgctgtacttctctttgttttgggcggctcggcctctgcagagatgtgggcagctggtc
aggatggccattcgggctcagcacagcaacgcagcccagactcagactggggaagcaaac
aggggctggacaggccaggagagcctgtcggacagtgatcctgagatgtgggagttgctg
cagagggagaaggacaggcagtgtcgtggcctggagctcattgcctcagagaacttctgc
agccgagctgcgctggaggccctggggtcctgtctgaacaacaagtactcggagggttat
cctggcaagagatactatgggggagcagaggtggtggatgaaattgagctgctgtgccag
cgccgggccttggaagcctttgacctggatcctgcacagtggggagtcaatgtccagccc
tactccgggtccccagccaacctggccgtctacacagcccttctgcaacctcacgaccgg
atcatggggctggacctgcccgatgggggccatctcacccacggctacatgtctgacgtc
aagcggatatcagccacgtccatcttcttcgagtctatgccctataagctcaaccccaaa
actggcctcattgactacaaccagctggcactgactgctcgacttttccggccacggctc
atcatagctggcaccagcgcctatgctcgcctcattgactacgcccgcatgagagaggtg
tgtgatgaagtcaaagcacacctgctggcagacatggcccacatcagtggcctggtggct
gccaaggtgattccctcgcctttcaagcacgcggacatcgtcaccaccactactcacaag
actcttcgaggggccaggtcagggctcatcttctaccggaaaggggtgaaggctgtggac
cccaagactggccgggagatcccttacacatttgaggaccgaatcaactttgccgtgttc
ccatccctgcaggggggcccccacaatcatgccattgctgcagtagctgtggccctaaag
caggcctgcacccccatgttccgggagtactccctgcaggttctgaagaatgctcgggcc
atggcagatgccctgctagagcgaggctactcactggtatcaggtggtactgacaaccac
ctggtgctggtggacctgcggcccaagggcctggatggagctcgggctgagcgggtgcta
gagcttgtatccatcactgccaacaagaacacctgtcctggagaccgaagtgccatcaca
ccgggcggcctgcggcttggggccccagccttaacttctcgacagttccgtgaggatgac
ttccggagagttgtggactttatagatgaaggggtcaacattggcttagaggtgaagagc
aagactgccaagctccaggatttcaaatccttcctgcttaaggactcagaaacaagtcag
cgtctggccaacctcaggcaacgggtggagcagtttgccagggccttccccatgcctggt
tttgatgagcattga |
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