KEGG   Homo sapiens (human): 64805
Entry
64805             CDS       T01001                                 
Symbol
P2RY12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999
Name
(RefSeq) purinergic receptor P2Y12
  KO
K04298  P2Y purinoceptor 12
Organism
hsa  Homo sapiens (human)
Pathway
hsa04082  Neuroactive ligand signaling
hsa04148  Efferocytosis
hsa04611  Platelet activation
Network
nt06535  Efferocytosis
nt06544  Neuroactive ligand signaling
  Element
N01747  Find-me signal (nucleotide)
N01908  ADP/UDP-glucose-P2RY-GNAI/O signaling pathway
Disease
H01235  Bleeding disorder platelet-type
Drug target
Cangrelor (DG01294): D03359 D03361<US>
Clopidogrel (DG00155): D00769<JP/US> D07729 D10823 D10824
Elinogrel (DG01295): D09607 D09608
Prasugrel: D05597<JP/US>
Regrelor disodium: D08983
Sumecigrel: D12979
Ticagrelor: D09017<JP/US>
Ticlopidine (DG00156): D01028<JP> D08594
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    64805 (P2RY12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    64805 (P2RY12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    64805 (P2RY12)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    64805 (P2RY12)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Base and nucleoside
   Purine / pyrimidine
    64805 (P2RY12)
SSDB
Motif
Pfam: 7tm_1
Other DBs
NCBI-GeneID: 64805
NCBI-ProteinID: NP_073625
OMIM: 600515
HGNC: 18124
Ensembl: ENSG00000169313
UniProt: Q9H244 A8K7T1
Structure
Position
3:complement(151336843..151384753)
AA seq 342 aa
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI
IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI
DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS
EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI
IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
NT seq 1029 nt   +upstreamnt  +downstreamnt
atgcaagccgtcgacaacctcacctctgcgcctggtaacaccagtctgtgcaccagagac
tacaaaatcacccaggtcctcttcccactgctctacactgtcctgttttttgttggactt
atcacaaatggcctggcgatgaggattttctttcaaatccggagtaaatcaaactttatt
atttttcttaagaacacagtcatttctgatcttctcatgattctgacttttccattcaaa
attcttagtgatgccaaactgggaacaggaccactgagaacttttgtgtgtcaagttacc
tccgtcatattttatttcacaatgtatatcagtatttcattcctgggactgataactatc
gatcgctaccagaagaccaccaggccatttaaaacatccaaccccaaaaatctcttgggg
gctaagattctctctgttgtcatctgggcattcatgttcttactctctttgcctaacatg
attctgaccaacaggcagccgagagacaagaatgtgaagaaatgctctttccttaaatca
gagttcggtctagtctggcatgaaatagtaaattacatctgtcaagtcattttctggatt
aatttcttaattgttattgtatgttatacactcattacaaaagaactgtaccggtcatac
gtaagaacgaggggtgtaggtaaagtccccaggaaaaaggtgaacgtcaaagttttcatt
atcattgctgtattctttatttgttttgttcctttccattttgcccgaattccttacacc
ctgagccaaacccgggatgtctttgactgcactgctgaaaatactctgttctatgtgaaa
gagagcactctgtggttaacttccttaaatgcatgcctggatccgttcatctattttttc
ctttgcaagtccttcagaaattccttgataagtatgctgaagtgccccaattctgcaaca
tctctgtcccaggacaataggaaaaaagaacaggatggtggtgacccaaatgaagagact
ccaatgtaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (9)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (38)   
   RefSeq(nuc) (2)   
   GenBank (18)   
   EMBL (18)   
3D Structure (5)   
   PDB (5)   
Protein domain (1)   
   Pfam (1)   
All databases (60)   

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