KEGG T01001: 6502

Homo sapiens (human): 6502

Entry

6502 CDS T01001

Gene name

SKP2, FBL1, FBXL1, FLB1, p45

Definition

(RefSeq) S-phase kinase associated protein 2

K03875

F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)

Organism

hsa Homo sapiens (human)

Pathway

hsa04068

FoxO signaling pathway

hsa04110

Cell cycle

hsa04120

Ubiquitin mediated proteolysis

hsa04150

mTOR signaling pathway

hsa05168

Herpes simplex infection

hsa05169

Epstein-Barr virus infection

hsa05200

Pathways in cancer

hsa05203

Viral carcinogenesis

hsa05222

Small cell lung cancer

Module

hsa_M00381

SCF-SKP2 complex

Network

N00091

p27-Cell cycle G1/S

N00264

EBV EBNA3C to p27-Cell cycle G1/S

N00484

EBV EBNA3C to p21-cell cycle G1/S

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    6502 (SKP2)
09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    6502 (SKP2)
   04150 mTOR signaling pathway
    6502 (SKP2)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    6502 (SKP2)
09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    6502 (SKP2)
   05203 Viral carcinogenesis
    6502 (SKP2)
  09162 Cancers: Specific types
   05222 Small cell lung cancer
    6502 (SKP2)
  09172 Infectious diseases: Viral
   05168 Herpes simplex infection
    6502 (SKP2)
   05169 Epstein-Barr virus infection
    6502 (SKP2)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    6502 (SKP2)
Ubiquitin system [BR:hsa04121]
Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Target recognizing subunit (F-box)
     6502 (SKP2)

SSDB

Motif

Pfam:

F-box-like F-box F-box_5 LRR_8

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q13309(Tbio)

UniProt:

Q13309 A0A024R069

Structure

PDB:

1FS1 2AST 1FQV 1FS2 2ASS 1LDK

Position

5p13.2

AA seq 424 aa
MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG
HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV
SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP
FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC
SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS
DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP
TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK
PSCL

NT seq 1275 nt +upstreamnt +downstreamnt
atgcacaggaagcacctccaggagattccagacctgagtagcaacgttgccaccagcttc
acgtggggatgggattccagcaagacttctgaactgctgtcaggcatgggggtctccgcc
ctggagaaagaggagcccgacagtgagaacatcccccaggaactgctctcaaacctgggc
cacccggagagccccccacggaaacggctgaagagcaaagggagtgacaaagactttgtg
attgtccgcaggcctaagctaaatcgagagaactttccaggtgtttcatgggactccctt
ccggatgagctgctcttgggaatcttttcctgtctgtgcctccctgagctgctaaaggtc
tctggtgtttgtaagaggtggtatcgcctagcgtctgatgagtctctatggcagacctta
gacctcacaggtaaaaatctgcacccggatgtgactggtcggttgctgtctcaaggggtg
attgccttccgctgcccacgatcatttatggaccaaccattggctgaacatttcagccct
tttcgtgtacagcacatggacctatcgaactcagttatagaagtgtccaccctccacggc
atactgtctcagtgttccaagttgcagaatctaagcctggaaggcctgcggctttcggat
cccattgtcaatactctcgcaaaaaactcaaatttagtgcgacttaacctttctgggtgt
tctggattctctgaatttgccctgcagactttgctaagcagctgttccagactggatgag
ctgaacctctcctggtgttttgatttcactgaaaagcatgtacaggtggctgttgcgcat
gtgtcagagaccatcacccagctgaatcttagcggctacagaaagaatctccagaaatca
gatctctctactttagttagaagatgccccaatcttgtccatctagacttaagtgatagt
gtcatgctaaagaatgactgctttcaggaatttttccagctcaactacctccaacaccta
tcactcagtcggtgctatgatataatacctgaaactttacttgaacttggagaaattccc
acactaaaaacactacaagtttttggaatcgtgccagatggtacccttcaactgttaaag
gaagcccttcctcatctacagattaattgctcccatttcaccaccattgccaggccaact
attggcaacaaaaagaaccaggagatatggggcatcaaatgccgactgacactgcaaaag
cccagttgtctatga

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