KEGG   Homo sapiens (human): 6505
Entry
6505              CDS       T01001                                 

Gene name
SLC1A1, DCBXA, EAAC1, EAAT3, SCZD18
Definition
(RefSeq) solute carrier family 1 member 1
  KO
K05612  solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04724  Glutamatergic synapse
hsa04974  Protein digestion and absorption
Disease
H00911  Dicarboxylic aminoaciduria
H01450  Obsessive-compulsive disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04974 Protein digestion and absorption
    6505 (SLC1A1)
  09156 Nervous system
   04724 Glutamatergic synapse
    6505 (SLC1A1)
   04721 Synaptic vesicle cycle
    6505 (SLC1A1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6505 (SLC1A1)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC1: High-affinity glutamate and neutral amino acid transporter
   6505 (SLC1A1)
SSDB
Motif
Pfam: SDF
Other DBs
NCBI-GeneID: 6505
NCBI-ProteinID: NP_004161
OMIM: 133550
HGNC: 10939
Ensembl: ENSG00000106688
Vega: OTTHUMG00000019468
Pharos: P43005(Tchem)
UniProt: P43005
Position
9p24.2
AA seq 524 aa
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILM
RMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGV
TQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMT
EESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFF
NALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVI
LPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLP
VGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMV
IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVN
IVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
NT seq 1575 nt   +upstreamnt  +downstreamnt
atggggaaaccggcgaggaaaggatgcgagtggaagcgcttcctgaagaataactgggtg
ttgctgtccaccgtggccgcggtggtgctaggcattaccacaggagtcttggttcgagaa
cacagcaacctctcaactctagagaaattctactttgcttttcctggagaaattctaatg
cggatgctgaaactcatcattttgccattaattatatccagcatgattacaggtgttgct
gcactggattccaacgtatccggaaaaattggtctgcgcgctgtcgtgtattatttctgt
accactctcattgctgttattctaggtattgtgctggtggtgagcatcaagcctggtgtc
acccagaaagtgggtgaaattgcgaggacaggcagcacccctgaagtcagtacggtggat
gccatgttagatctcatcaggaatatgttccctgagaatcttgtccaggcctgttttcag
cagtacaaaactaagcgtgaagaagtgaagcctcccagcgatccagagatgaacatgaca
gaagagtccttcacagctgtcatgacaactgcaatttccaagaacaaaacaaaggaatac
aaaattgttggcatgtattcagatggcataaacgtcctgggcttgattgtcttttgcctt
gtctttggacttgtcattggaaaaatgggagaaaagggacaaattctggtggatttcttc
aatgctttgagtgatgcaaccatgaaaatcgttcagatcatcatgtgttatatgccacta
ggtattttgttcctgattgctgggaagatcatagaagttgaagactgggaaatattccgc
aagctgggcctttacatggccacagtcctgactgggcttgcaatccactccattgtaatt
ctcccgctgatatatttcatagtcgtacgaaagaaccctttccgatttgccatgggaatg
gcccaggctctcctgacagctctcatgatctcttccagttcagcaacactgcctgtcacc
ttccgctgtgctgaagaaaataaccaggtggacaagaggatcactcgattcgtgttaccc
gttggtgcaacaatcaacatggatgggactgcgctctatgaagcagtggcagcggtgttt
attgcacagttgaatgacctggacttgggcattgggcagatcatcaccatcagtatcacg
gccacatctgccagcatcggagctgctggcgtgccccaggctggcctggtgaccatggtg
attgtgctgagtgccgtgggcctgcccgccgaggatgtcaccctgatcattgctgtcgac
tggctcctggaccggttcaggaccatggtcaacgtccttggtgatgcttttgggacgggc
attgtggaaaagctctccaagaaggagctggagcagatggatgtttcatctgaagtcaac
attgtgaatccctttgccttggaatccacaatccttgacaacgaagactcagacaccaag
aagtcttatgtcaatggaggctttgcagtagacaagtctgacaccatctcattcacccag
acctcacagttctag

KEGG   Homo sapiens (human): 6506
Entry
6506              CDS       T01001                                 

Gene name
SLC1A2, EAAT2, EIEE41, GLT-1, HBGT
Definition
(RefSeq) solute carrier family 1 member 2
  KO
K05613  solute carrier family 1 (glial high affinity glutamate transporter), member 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04724  Glutamatergic synapse
hsa05014  Amyotrophic lateral sclerosis (ALS)
hsa05016  Huntington disease
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    6506 (SLC1A2)
   04721 Synaptic vesicle cycle
    6506 (SLC1A2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis (ALS)
    6506 (SLC1A2)
   05016 Huntington disease
    6506 (SLC1A2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6506 (SLC1A2)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC1: High-affinity glutamate and neutral amino acid transporter
   6506 (SLC1A2)
SSDB
Motif
Pfam: SDF
Other DBs
NCBI-GeneID: 6506
NCBI-ProteinID: NP_004162
OMIM: 600300
HGNC: 10940
Ensembl: ENSG00000110436
Vega: OTTHUMG00000044391
Pharos: P43004(Tchem)
UniProt: P43004
Position
11p13
AA seq 574 aa
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
NT seq 1725 nt   +upstreamnt  +downstreamnt
atggcatctacggaaggtgccaacaatatgcccaagcaggtggaagtgcgaatgcacgac
agtcatcttggctcagaggaacccaagcaccggcacctgggcctgcgcctgtgtgacaag
ctggggaagaatctgctgctcaccctgacggtgtttggtgtcatcctgggagcagtgtgt
ggagggcttcttcgcttggcatctcccatccaccctgatgtggttatgttaatagccttc
ccaggggatatactcatgaggatgctaaaaatgctcattctccctctaatcatctccagc
ttaatcacagggttgtcaggcctggatgctaaggctagtggccgcttgggcacgagagcc
atggtgtattacatgtccacgaccatcattgctgcagtactgggggtcattctggtcttg
gctatccatccaggcaatcccaagctcaagaagcagctggggcctgggaagaagaatgat
gaagtgtccagcctggatgccttcctggaccttattcgaaatctcttccctgaaaacctt
gtccaagcctgctttcaacagattcaaacagtgacgaagaaagtcctggttgcaccaccg
ccggacgaggaggccaacgcaaccagcgctgttgtctctctgttgaacgagactgtgact
gaggtgccggaggagactaagatggttatcaagaagggcctggagttcaaggatgggatg
aacgtcttaggtctgatagggtttttcattgcttttggcatcgctatggggaagatggga
gatcaggccaagctgatggtggatttcttcaacattttgaatgagattgtaatgaagtta
gtgatcatgatcatgtggtactctcccctgggtatcgcctgcctgatctgtggaaagatc
attgcaatcaaggacttagaagtggttgctaggcaactggggatgtacatggtaacagtg
atcataggcctcatcatccacgggggcatctttctccccttgatttactttgtagtgacc
aggaaaaaccccttctccttttttgctggcattttccaagcttggatcactgccctgggc
accgcttccagtgctggaactttgcctgtcacctttcgttgcctggaagaaaatctgggg
attgataagcgtgtgactagattcgtccttcctgttggagcaaccattaacatggatggt
acagccctttatgaagcggtagccgccatctttatagcccaaatgaatggtgttgtcctg
gatggaggacagattgtgactgtaagcctcacagccaccctggcaagcgtcggcgcggcc
agtatccccagtgccgggctggtcaccatgctcctcattctgacagccgtgggcctgcca
acagaggacatcagcctgctggtggctgtggactggctgctggacaggatgagaacttca
gtcaatgttgtgggtgactcttttggggctgggatagtctatcacctctccaagtctgag
ctggataccattgactcccagcatcgagtgcatgaagatattgaaatgaccaagactcaa
tccatttatgatgacatgaagaaccacagggaaagcaactctaatcaatgtgtctatgct
gcacacaactctgtcatagtagatgaatgcaaggtaactctggcagccaatggaaagtca
gccgactgcagtgttgaggaagaaccttggaaacgtgagaaataa

KEGG   Homo sapiens (human): 6507
Entry
6507              CDS       T01001                                 

Gene name
SLC1A3, EA6, EAAT1, GLAST, GLAST1
Definition
(RefSeq) solute carrier family 1 member 3
  KO
K05614  solute carrier family 1 (glial high affinity glutamate transporter), member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04724  Glutamatergic synapse
hsa05016  Huntington disease
Disease
H00749  Episodic ataxias
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    6507 (SLC1A3)
   04721 Synaptic vesicle cycle
    6507 (SLC1A3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    6507 (SLC1A3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6507 (SLC1A3)
   04147 Exosome [BR:hsa04147]
    6507 (SLC1A3)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC1: High-affinity glutamate and neutral amino acid transporter
   6507 (SLC1A3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of cortical neuronal cells
   6507 (SLC1A3)
SSDB
Motif
Pfam: SDF MT
Other DBs
NCBI-GeneID: 6507
NCBI-ProteinID: NP_004163
OMIM: 600111
HGNC: 10941
Ensembl: ENSG00000079215
Vega: OTTHUMG00000090793
Pharos: P43003(Tchem)
UniProt: P43003 Q8N169 A0A024R050
Position
5p13.2
AA seq 542 aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
NT seq 1629 nt   +upstreamnt  +downstreamnt
atgactaaaagcaatggagaagagcccaagatggggggcaggatggagagattccagcag
ggagtccgtaaacgcacacttttggccaagaagaaagtgcagaacattacaaaggaggat
gttaaaagttacctgtttcggaatgcttttgtgctgctcacagtcaccgctgtcattgtg
ggtacaatccttggatttaccctccgaccatacagaatgagctaccgggaagtcaagtac
ttctcctttcctggggaacttctgatgaggatgttacagatgctggtcttaccacttatc
atctccagtcttgtcacaggaatggcggcgctagatagtaaggcatcagggaagatggga
atgcgagctgtagtctattatatgactaccaccatcattgctgtggtgattggcataatc
attgtcatcatcatccatcctgggaagggcacaaaggaaaacatgcacagagaaggcaaa
attgtacgagtgacagctgcagatgccttcctggacttgatcaggaacatgttccctcca
aatctggtagaagcctgctttaaacagtttaaaaccaactatgagaagagaagctttaaa
gtgcccatccaggccaacgaaacgcttgtgggtgctgtgataaacaatgtgtctgaggcc
atggagactcttacccgaatcacagaggagctggtcccagttccaggatctgtgaatgga
gtcaatgccctgggtctagttgtcttctccatgtgcttcggttttgtgattggaaacatg
aaggaacaggggcaggccctgagagagttctttgattctcttaacgaagccatcatgaga
ctggtagcagtaataatgtggtatgcccccgtgggtattctcttcctgattgctgggaag
attgtggagatggaagacatgggtgtgattggggggcagcttgccatgtacaccgtgact
gtcattgttggcttactcattcacgcagtcatcgtcttgccactcctctacttcttggta
acacggaaaaacccttgggtttttattggagggttgctgcaagcactcatcaccgctctg
gggacctcttcaagttctgccaccctacccatcaccttcaagtgcctggaagagaacaat
ggcgtggacaagcgcgtcaccagattcgtgctccccgtaggagccaccattaacatggat
gggactgccctctatgaggctttggctgccattttcattgctcaagttaacaactttgaa
ctgaacttcggacaaattattacaatcagcatcacagccacagctgccagtattggggca
gctggaattcctcaggcgggcctggtcactatggtcattgtgctgacatctgtcggcctg
cccactgacgacatcacgctcatcatcgcggtggactggttcctggatcgcctccggacc
accaccaacgtactgggagactccctgggagctgggattgtggagcacttgtcacgacat
gaactgaagaacagagatgttgaaatgggtaactcagtgattgaagagaatgaaatgaag
aaaccatatcaactgattgcacaggacaatgaaactgagaaacccatcgacagtgaaacc
aagatgtag

KEGG   Homo sapiens (human): 6511
Entry
6511              CDS       T01001                                 

Gene name
SLC1A6, EAAT4
Definition
(RefSeq) solute carrier family 1 member 6
  KO
K05617  solute carrier family 1 (high affinity glutamate/aspartate transporter), member 6
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04724  Glutamatergic synapse
hsa05017  Spinocerebellar ataxia
Network
nt06440  Transcription
nt06462  Spinocerebellar ataxia
  Element
N00965  RORA-mediated transcription
N00966  Mutation-caused aberrant ATXN1 to RORA-mediated transcription
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    6511 (SLC1A6)
   04721 Synaptic vesicle cycle
    6511 (SLC1A6)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    6511 (SLC1A6)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6511 (SLC1A6)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC1: High-affinity glutamate and neutral amino acid transporter
   6511 (SLC1A6)
SSDB
Motif
Pfam: SDF
Other DBs
NCBI-GeneID: 6511
NCBI-ProteinID: NP_005062
OMIM: 600637
HGNC: 10944
Ensembl: ENSG00000105143
Vega: OTTHUMG00000183351
Pharos: P48664(Tchem)
UniProt: P48664 B7Z7Q5
Position
19p13.12
AA seq 564 aa
MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFIL
LTVSAVVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLD
NKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMD
LIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENV
TRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLN
EAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPL
IYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGA
TVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVL
TSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLG
KPYKSLMAQEKGASRGRGGNESAM
NT seq 1695 nt   +upstreamnt  +downstreamnt
atgagcagccatggcaacagcctgttcctgcgggagagcggccagcggctgggccgggtg
ggctggctgcagcggctgcaggaaagcctgcagcagagagcactgcgcacgcgcctgcgc
ctgcagaccatgaccctcgagcacgtgctgcgcttcctgcgccgaaacgccttcattctg
ctgacggtcagcgccgtggtcattggggtcagcctggcctttgccctgcgcccatatcag
ctcacctaccgccagatcaagtacttctcttttcctggagagcttctgatgaggatgctg
cagatgctggtgttacctctcattgtctccagcctggtcacaggtatggcatccctggac
aacaaggccacggggcggatggggatgcgggcagctgtgtactacatggtgaccaccatc
atcgcggtcttcatcggcatcctcatggtcaccatcatccatcccgggaagggctccaag
gaggggctgcaccgggagggccggatcgagaccatccccacagctgatgccttcatggac
ctgatcagaaatatgtttccaccaaaccttgtggaggcctgcttcaaacagttcaagacg
cagtacagcacgagggtggtaaccaggaccatggtgaggacagagaacgggtctgagccg
ggtgcctccatgcctcctccattctcagtggagaacggaaccagcttcctggaaaatgtc
actcgggccttgggtaccctgcaggagatgctgagctttgaggagactgtacccgtgcct
ggctccgccaatggcatcaacgccctgggcctcgtggtcttctctgtggcctttgggctg
gtcattggtggcatgaaacacaagggcagagtcctcagggacttcttcgacagcctcaat
gaggctattatgaggctggtgggcatcattatctggtatgcacctgtgggcatcctgttc
ctgattgctgggaagattctggagatggaagacatggccgtcctggggggtcagctgggc
atgtacaccctgaccgtcatcgtgggcctgttcctccatgccggcattgtccttcccctc
atctacttcctcgtcactcaccggaaccccttccccttcattgggggcatgctacaagcc
ctcatcaccgctatgggcacgtcttccagctcggcaacgctgcccatcaccttccgctgc
ctggaggagggcctgggtgtggaccgccgcatcaccaggttcgtcctgcccgtgggcgcc
acggtcaacatggatggcactgccctctacgaggccctggctgccatcttcattgctcaa
gttaacaactacgagctcaacctgggtcagatcacaaccatcagcatcacggccacagca
gccagtgttggggctgctggcatcccccaggcgggtctggtcaccatggtcattgtgctt
acgtcggtcggcttgcccacggaagacatcacgctcatcattgccgtggactggttcctt
gaccggcttcgcacaatgaccaacgtactgggggactcaattggagcggccgtcatcgag
cacttgtctcagcgggagctggagcttcaggaagctgagcttaccctccccagcctgggg
aaaccctacaagtccctcatggcacaggagaagggggcatcccggggacggggaggcaac
gagagtgctatgtga

KEGG   Homo sapiens (human): 6512
Entry
6512              CDS       T01001                                 

Gene name
SLC1A7, AAAT, EAAT5
Definition
(RefSeq) solute carrier family 1 member 7
  KO
K05618  solute carrier family 1 (glutamate transporter), member 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04724  Glutamatergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    6512 (SLC1A7)
   04721 Synaptic vesicle cycle
    6512 (SLC1A7)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6512 (SLC1A7)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC1: High-affinity glutamate and neutral amino acid transporter
   6512 (SLC1A7)
SSDB
Motif
Pfam: SDF DUF2417
Other DBs
NCBI-GeneID: 6512
NCBI-ProteinID: NP_006662
OMIM: 604471
HGNC: 10945
Ensembl: ENSG00000162383
Vega: OTTHUMG00000008937
Pharos: O00341(Tchem)
UniProt: O00341 F1T0D3
Position
1p32.3
AA seq 560 aa
MVPHAILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRM
LKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAA
QKETTEQSGKPIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPR
RILIYGVQEENGSHVQNFALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLGRMG
DSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTV
VCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNH
IDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAA
GIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICRKD
FARDTGTEKLLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVEQDEE
LPAASLNHCTIQISELETNV
NT seq 1683 nt   +upstreamnt  +downstreamnt
atggtgccgcatgccatcttggcacgggggagggacgtgtgcaggcggaatggactcctc
atcctgtctgtgctgtctgtcatcgtgggctgcctcctcggcttcttcttgaggacccgg
cgcctctcaccacaggaaattagttacttccagttccctggagagctcctgatgaggatg
ctgaagatgatgatcctgccactggtggtctccagcttgatgtccggacttgcctccctg
gatgccaagacctctagccgcctgggcgtcctcaccgtggcgtactacctgtggaccacc
ttcatggctgtcatcgtgggcatcttcatggtctccatcatccacccaggcagcgcggcc
cagaaggagaccacggagcagagtgggaagcccatcatgagctcagccgatgccctgttg
gacctcatccggaacatgttcccagccaacctagtagaagccacattcaaacagtaccgc
accaagaccaccccagttgtcaagtcccccaaggtggcaccagaggaggcccctcctcgg
cggatcctcatctacggggtccaggaggagaatggctcccatgtgcagaacttcgccctg
gacctgaccccgccgcccgaggtcgtttacaagtcagagccgggcaccagcgatggcatg
aatgtgctgggcatcgtcttcttctctgccaccatgggcatcatgctgggccgcatgggt
gacagcggggcccccctggtcagcttctgccagtgcctcaatgagtcggtcatgaagatc
gtggcggtggctgtgtggtatttccccttcggcattgtgttcctcattgcgggtaagatc
ctggagatggacgaccccagggccgtcggcaagaagctgggcttctactcagtcaccgtg
gtgtgcgggctggtgctccacgggctctttatcctgcccctgctctacttcttcatcacc
aagaagaatcccatcgtcttcatccgtggcatcctgcaggctctgctcatcgcgctggcc
acctcctccagctcagccacactgcccatcaccttcaagtgcctgctggagaacaaccac
atcgaccggcgcatcgctcgcttcgtgctgcccgtgggtgccaccatcaacatggacggc
actgcgctctacgaggctgtggccgccatcttcatcgcccaggtcaacaactacgagctg
gactttggccagatcatcaccatcagtatcacagccactgcagccagcattggggcagct
ggcatcccccaggccggcctcgtcaccatggtcatcgtgctcacctccgtgggactgccc
accgatgacatcaccctcatcattgccgttgactgggctctggaccgtttccgcaccatg
attaacgtgctgggtgatgcgctggcagcggggatcatggcccatatatgtcggaaggat
tttgcccgggacacaggcaccgagaaactgctgccctgcgagaccaagccagtgagcctc
caggagatcgtggcagcccagcagaatggctgtgtgaagagtgtagccgaggcctccgag
ctcaccctgggccccacctgcccccaccacgtccccgttcaagtggagcaggatgaggag
ctgcccgctgcgagtctgaaccactgcaccatccagatcagtgagctggagaccaatgtc
tga

KEGG   Homo sapiens (human): 6529
Entry
6529              CDS       T01001                                 

Gene name
SLC6A1, GABATHG, GABATR, GAT1, MAE
Definition
(RefSeq) solute carrier family 6 member 1
  KO
K05034  solute carrier family 6 (neurotransmitter transporter, GABA) member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04727  GABAergic synapse
Disease
H02361  Myoclonic-atonic epilepsy
Drug target
Gabapentin (DG01245): D00332 D09539
Tiagabine (DG00850): D02097 D08588
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    6529 (SLC6A1)
   04721 Synaptic vesicle cycle
    6529 (SLC6A1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6529 (SLC6A1)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6529 (SLC6A1)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6529
NCBI-ProteinID: NP_001335179
OMIM: 137165
HGNC: 11042
Ensembl: ENSG00000157103
Vega: OTTHUMG00000044208
Pharos: P30531(Tclin)
UniProt: P30531 A0A024R2K8
Position
3p25.3
AA seq 599 aa
MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
NT seq 1800 nt   +upstreamnt  +downstreamnt
atggcgaccaacggcagcaaggtggccgacgggcagatctccaccgaggtcagcgaggcc
cctgtggccaatgacaagcccaaaaccttggtggtcaaggtgcagaagaaggcggcagac
ctccccgaccgggacacgtggaagggccgcttcgacttcctcatgtcctgtgtgggctat
gccatcggcctgggcaacgtctggaggttcccctatctctgcgggaaaaatggtggggga
gccttcctgatcccctatttcctgacactcatctttgcgggggtcccactcttcctgctg
gagtgctccctgggccagtacacctccatcggggggctaggggtatggaagctggctcct
atgttcaagggcgtgggccttgcggctgctgtgctatcattctggctgaacatctactac
atcgtcatcatctcctgggccatttactacctgtacaactccttcaccacgacactgccg
tggaaacagtgcgacaacccctggaacacagaccgctgcttctccaactacagcatggtc
aacactaccaacatgaccagcgctgtggtggagttctgggagcgcaacatgcatcagatg
acggacgggctggataagccaggtcagatccgctggccactggccatcacgctggccatc
gcctggatccttgtgtatttctgtatctggaagggtgttggctggactggaaaggtggtc
tacttttcagccacatacccctacatcatgctgatcatcctgttcttccgtggagtgacg
ctgcccggggccaaggagggcatcctcttctacatcacacccaacttccgcaagctgtct
gactccgaggtgtggctggatgcggcaacccagatcttcttctcatacgggctgggcctg
gggtccctgatcgctctcgggagctacaactctttccacaacaatgtctacagggactcc
atcatcgtctgctgcatcaattcgtgcaccagcatgttcgcaggattcgtcatcttctcc
atcgtgggcttcatggcccatgtcaccaagaggtccattgctgatgtggcggcctcaggc
cccgggctggcgttcctggcatacccagaggcggtgacccagctgcctatctccccactc
tgggccatcctcttcttctccatgctgttgatgctgggcattgacagccagttctgcact
gtggagggcttcatcacagccctggtggatgagtaccccaggctcctccgcaaccgcaga
gagctcttcattgctgctgtctgcatcatctcctacctgatcggtctctctaacatcact
caggggggtatttatgtcttcaaactctttgactactactctgccagtggcatgagcctg
ctgttcctcgtgttctttgaatgtgtctctatttcctggttttacggtgtcaaccgattc
tatgacaatatccaagagatggttggatccaggccctgcatctggtggaaactctgctgg
tctttcttcacaccaatcattgtggcgggcgtgttcattttcagtgctgtgcagatgacg
ccactcaccatgggaaactatgttttccccaagtggggccagggtgtgggctggctgatg
gctctgtcttccatggtcctcatccccgggtacatggcctacatgttcctcaccttaaag
ggctccctgaagcagcgcatccaagtcatggtccagcccagcgaagacatcgttcgccca
gagaatggtcctgagcagccccaggcgggcagctccaccagcaaggaggcctacatctag

KEGG   Homo sapiens (human): 6530
Entry
6530              CDS       T01001                                 

Gene name
SLC6A2, NAT1, NET, NET1, SLC6A5
Definition
(RefSeq) solute carrier family 6 member 2
  KO
K05035  solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
Disease
H01031  Orthostatic intolerance
Drug target
Amezinium metilsulfate: D01304
Amfepramone (DG00104): D03801 D07444
Amfetamine (DG00966): D02074 D07445
Amitifadine (DG01386): D10088 D10089
Amitriptyline (DG00934): D00809 D07448
Amitriptylinoxide: D07449
Amoxapine: D00228
Amphetamine aspartate monohydrate: D11622
Ampreloxetine (DG03081): D11688 D11689
Atomoxetine (DG00970): D02574 D07473
Benzfetamine (DG01755): D07514 D07515
Bupropion (DG00957): D00817 D07591 D07938
Centanafadine (DG01858): D10697 D10698
Cidoxepin hydrochloride: D03491
Clomipramine (DG00929): D00811 D07727
Cocaine (DG00808): D00110 D02182
Dasotraline (DG01989): D10700 D10870
Desipramine (DG00927): D00812 D07791
Desvenlafaxine (DG00963): D02570 D07793 D11619
Dexamfetamine (DG00967): D02078 D03740
Dexmethylphenidate (DG00972): D03721 D07806
Dextroamphetamine saccharate: D11623
Dosulepin (DG00940): D01546 D07872
Doxepin (DG00937): D00814 D07875
Duloxetine (DG00962): D01179 D07880
Edivoxetine (DG01310): D09890 D09891
Esreboxetine (DG01309): D09340 D09341
Guanethidine (DG00258): D02237 D04382 D08030
Hydroxyamphetamine hydrobromide: D04473
Imipramine (DG00928): D00815 D08070 D08071
Imipraminoxide (DG01542): D07334 D08072
Indeloxazine (DG02869): D02170 D08077
Levomilnacipran (DG01387): D10072 D10133
Liafensine: D10443
Lisdexamfetamine (DG00973): D04747 D08130
Lofepramine (DG00932): D01285 D08140
Lortalamine: D04781
Maprotiline (DG00941): D00818 D02566
Mazindol: D00367
Metamfetamine (DG00968): D02242 D08187
Methylphenidate (DG00969): D01296 D04999
Midomafetamine: D11172
Milnacipran (DG00960): D01107 D08222
Napamezole hydrochloride: D05119
Napitane mesylate: D05120
Nisoxetine: D05173
Nomifensine: D05200
Nortriptyline (DG00935): D00816 D08288
Oxaprotiline hydrochloride: D05284
Phendimetrazine (DG01537): D02080 D08347 D08348
Phenmetrazine hydrochloride: D05454
Phentermine (DG00102): D05458 D05459
Protriptyline (DG00936): D00484 D08447
Pyrovalerone hydrochloride: D05663
Radafaxine hydrochloride: D05692
Reboxetine (DG00961): D02573 D08472
Sibutramine (DG00108): D02571 D08513
Solriamfetol (DG02989): D11315 D11328
Talopram hydrochloride: D05997
Tampramine fumarate: D02704
Tandamine hydrochloride: D06004
Tapentadol (DG00826): D06007 D10199
Trimipramine (DG00931): D00394 D02408
Venlafaxine (DG00959): D00821 D08670
Viloxazine (DG00956): D02572 D08673
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04721 Synaptic vesicle cycle
    6530 (SLC6A2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6530 (SLC6A2)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6530 (SLC6A2)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6530
NCBI-ProteinID: NP_001034
OMIM: 163970
HGNC: 11048
Ensembl: ENSG00000103546
Vega: OTTHUMG00000133208
Pharos: P23975(Tclin)
UniProt: P23975 A0A024R6T9
Position
16q12.2
AA seq 617 aa
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
NT seq 1854 nt   +upstreamnt  +downstreamnt
atgcttctggcgcggatgaacccgcaggtgcagcccgagaacaacggggcggacacgggt
ccagagcagccccttcgggcgcgcaaaactgcggagctgctggtggtgaaggagcgcaac
ggcgtccagtgcctgctggcgccccgcgacggcgacgcgcagccccgggagacctggggc
aagaagatcgacttcctgctgtccgtagtcggcttcgcagtggacctggccaacgtgtgg
cgcttcccctacctctgctacaagaacggcggcggtgccttcttgatcccgtacacactg
ttccttatcatcgcggggatgcccctgttctacatggagctggctctgggacagtacaac
cgggagggggctgccaccgtttggaaaatctgcccattcttcaaaggcgttggctatgct
gtcatcctgatcgccctgtacgttggcttctactacaacgtcatcatcgcctggtcactc
tactacctcttctcctccttcaccctcaacctgccctggaccgactgtggccacacctgg
aacagccccaactgtaccgaccccaagctcctcaatggctccgtgcttggcaaccacacc
aagtactccaagtacaagttcacgccggcagccgagttttatgagcgtggtgtcctgcac
cttcacgagagcagcgggattcatgacatcggcctgccccagtggcagctcttgctctgt
ctgatggtcgtcgtcatcgtcttgtattttagcctctggaaaggggtgaagacatcagga
aaggtggtgtggatcacagccacgctgccttacttcgtgctgttcgtgctcctggtccat
ggcgtcacgctgcccggagcctccaatggcatcaatgcctacctgcacatcgacttctac
cgcttgaaagaggccacggtatggattgatgccgcaactcagatatttttttccttgggg
gctggatttggagtattgattgcatttgccagttacaacaaatttgacaacaactgttac
agggatgccctgctgaccagcagcatcaactgtatcaccagcttcgtctctgggttcgcc
atcttctccatccttggttacatggcccatgaacacaaggtcaacattgaggatgtggcc
acagaaggagctggcctagtgttcatcctgtatccagaggccatttctaccctgtctgga
tctacattctgggctgttgtgtttttcgtcatgctcctggcgctgggccttgacagctca
atgggaggcatggaggctgtcatcacgggcctggcagatgacttccaggtcctgaagcga
caccggaaactcttcacatttggcgtcaccttcagcactttccttctcgccctgttctgc
ataaccaagggtggaatttacgtcttgaccctcctggacacctttgctgcgggcacctcc
atcctttttgctgtcctcatggaagccatcggagtttcctggttttatggagtggacagg
ttcagcaacgacatccagcagatgatggggttcaggccgggtctatactggagactgtgc
tggaagttcgtcagtcctgccttcctcctgttcgtggttgtggtcagcatcatcaacttc
aagccactcacctacgacgactacatcttcccgccctgggccaactgggtggggtggggc
atcgccctgtcctccatggtcctggtgcccatctacgtcatctataagttcctcagcacg
cagggctctctttgggagagactggcctatggcatcacgccagagaacgagcaccacctg
gtggctcagagggacatcagacagttccagttgcaacactggctggccatctga

KEGG   Homo sapiens (human): 6531
Entry
6531              CDS       T01001                                 

Gene name
SLC6A3, DAT, DAT1, PKDYS, PKDYS1
Definition
(RefSeq) solute carrier family 6 member 3
  KO
K05036  solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
Drug target
Amfepramone (DG00104): D03801 D07444
Amfetamine (DG00966): D02074 D07445
Amfonelic acid: D02897
Amitifadine (DG01386): D10088 D10089
Amphetamine aspartate monohydrate: D11622
Armodafinil: D03215
Benzfetamine (DG01755): D07514 D07515
Brasofensine maleate: D03153
Bupropion (DG00957): D00817 D07591 D07938
Centanafadine (DG01858): D10697 D10698
Cocaine (DG00808): D00110 D02182
Dasotraline (DG01989): D10700 D10870
Dexamfetamine (DG00967): D02078 D03740
Dexmethylphenidate (DG00972): D03721 D07806
Dextroamphetamine saccharate: D11623
Iodine ioflupane (123I): D10014
Lisdexamfetamine (DG00973): D04747 D08130
Mazindol: D00367
Metamfetamine (DG00968): D02242 D08187
Methylphenidate (DG00969): D01296 D04999
Midomafetamine: D11172
Napamezole hydrochloride: D05119
Phenmetrazine hydrochloride: D05454
Phentermine (DG00102): D05458 D05459
Pyrovalerone hydrochloride: D05663
Radafaxine hydrochloride: D05692
Sibutramine (DG00108): D02571 D08513
Solriamfetol (DG02989): D11315 D11328
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    6531 (SLC6A3)
   04721 Synaptic vesicle cycle
    6531 (SLC6A3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    6531 (SLC6A3)
  09165 Substance dependence
   05030 Cocaine addiction
    6531 (SLC6A3)
   05031 Amphetamine addiction
    6531 (SLC6A3)
   05034 Alcoholism
    6531 (SLC6A3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6531 (SLC6A3)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6531 (SLC6A3)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6531
NCBI-ProteinID: NP_001035
OMIM: 126455
HGNC: 11049
Ensembl: ENSG00000142319
Vega: OTTHUMG00000131016
Pharos: Q01959(Tclin)
UniProt: Q01959
Position
5p15.33
AA seq 620 aa
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
NT seq 1863 nt   +upstreamnt  +downstreamnt
atgagtaagagcaaatgctccgtgggactcatgtcttccgtggtggccccggctaaggag
cccaatgccgtgggcccgaaggaggtggagctcatccttgtcaaggagcagaacggagtg
cagctcaccagctccaccctcaccaacccgcggcagagccccgtggaggcccaggatcgg
gagacctggggcaagaagatcgactttctcctgtccgtcattggctttgctgtggacctg
gccaacgtctggcggttcccctacctgtgctacaaaaatggtggcggtgccttcctggtc
ccctacctgctcttcatggtcattgctgggatgccacttttctacatggagctggccctc
ggccagttcaacagggaaggggccgctggtgtctggaagatctgccccatactgaaaggt
gtgggcttcacggtcatcctcatctcactgtatgtcggcttcttctacaacgtcatcatc
gcctgggcgctgcactatctcttctcctccttcaccacggagctcccctggatccactgc
aacaactcctggaacagccccaactgctcggatgcccatcctggtgactccagtggagac
agctcgggcctcaacgacacttttgggaccacacctgctgccgagtactttgaacgtggc
gtgctgcacctccaccagagccatggcatcgacgacctggggcctccgcggtggcagctc
acagcctgcctggtgctggtcatcgtgctgctctacttcagcctctggaagggcgtgaag
acctcagggaaggtggtatggatcacagccaccatgccatacgtggtcctcactgccctg
ctcctgcgtggggtcaccctccctggagccatagacggcatcagagcatacctgagcgtt
gacttctaccggctctgcgaggcgtctgtttggattgacgcggccacccaggtgtgcttc
tccctgggcgtggggttcggggtgctgatcgccttctccagctacaacaagttcaccaac
aactgctacagggacgcgattgtcaccacctccatcaactccctgacgagcttctcctcc
ggcttcgtcgtcttctccttcctggggtacatggcacagaagcacagtgtgcccatcggg
gacgtggccaaggacgggccagggctgatcttcatcatctacccggaagccatcgccacg
ctccctctgtcctcagcctgggccgtggtcttcttcatcatgctgctcaccctgggtatc
gacagcgccatgggtggtatggagtcagtgatcaccgggctcatcgatgagttccagctg
ctgcacagacaccgtgagctcttcacgctcttcatcgtcctggcgaccttcctcctgtcc
ctgttctgcgtcaccaacggtggcatctacgtcttcacgctcctggaccattttgcagcc
ggcacgtccatcctctttggagtgctcatcgaagccatcggagtggcctggttctatggt
gttgggcagttcagcgacgacatccagcagatgaccgggcagcggcccagcctgtactgg
cggctgtgctggaagctggtcagcccctgctttctcctgttcgtggtcgtggtcagcatt
gtgaccttcagacccccccactacggagcctacatcttccccgactgggccaacgcgctg
ggctgggtcatcgccacatcctccatggccatggtgcccatctatgcggcctacaagttc
tgcagcctgcctgggtcctttcgagagaaactggcctacgccattgcacccgagaaggac
cgtgagctggtggacagaggggaggtgcgccagttcacgctccgccactggctcaaggtg
tag

KEGG   Homo sapiens (human): 6532
Entry
6532              CDS       T01001                                 

Gene name
SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT
Definition
(RefSeq) solute carrier family 6 member 4
  KO
K05037  solute carrier family 6 (neurotransmitter transporter, serotonin) member 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Disease
H01450  Obsessive-compulsive disorder
Drug target
Alaproclate: D02787
Amitifadine (DG01386): D10088 D10089
Amitriptyline (DG00934): D00809 D07448
Amitriptylinoxide: D07449
Amoxapine: D00228
Ampreloxetine (DG03081): D11688 D11689
Centanafadine (DG01858): D10697 D10698
Cidoxepin hydrochloride: D03491
Citalopram (DG00943): D00822 D07704 D07705
Clomipramine (DG00929): D00811 D07727
Cocaine (DG00808): D00110 D02182
Dapoxetine: D03649
Desipramine (DG00927): D00812 D07791
Desvenlafaxine (DG00963): D02570 D07793 D11619
Dexfenfluramine (DG00105): D03713 D07805
Dexmethylphenidate (DG00972): D03721 D07806
Dosulepin (DG00940): D01546 D07872
Doxepin (DG00937): D00814 D07875
Duloxetine (DG00962): D01179 D07880
Escitalopram (DG00947): D02567 D07913
Fenfluramine (DG00103): D04148 D07945
Fluoxetine (DG00942): D00326 D00823
Fluvoxamine (DG00946): D00824 D07984
Imipramine (DG00928): D00815 D08070 D08071
Imipraminoxide (DG01542): D07334 D08072
Indeloxazine (DG02869): D02170 D08077
Levomilnacipran (DG01387): D10072 D10133
Liafensine: D10443
Lofepramine (DG00932): D01285 D08140
Lubazodone hydrochloride: D04788
Lumateperone (DG02937): D11169 D11170
Mazindol: D00367
Metamfetamine (DG00968): D02242 D08187
Midomafetamine: D11172
Milnacipran (DG00960): D01107 D08222
Nortriptyline (DG00935): D00816 D08288
Paroxetine (DG00944): D02260 D02362 D05374 D05375
Phentermine (DG00102): D05458 D05459
Pirandamine hydrochloride: D05491
Protriptyline (DG00936): D00484 D08447
Sertraline (DG00945): D00825 D02360
Sibutramine (DG00108): D02571 D08513
Trazodone (DG00952): D00820 D08626
Trimipramine (DG00931): D00394 D02408
Venlafaxine (DG00959): D00821 D08670
Vilazodone (DG00964): D09698 D09699
Vortioxetine (DG00965): D10184 D10185
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    6532 (SLC6A4)
   04721 Synaptic vesicle cycle
    6532 (SLC6A4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6532 (SLC6A4)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6532 (SLC6A4)
SSDB
Motif
Pfam: SNF 5HT_transport_N
Other DBs
NCBI-GeneID: 6532
NCBI-ProteinID: NP_001036
OMIM: 182138
HGNC: 11050
Ensembl: ENSG00000108576
Vega: OTTHUMG00000132751
Pharos: P31645(Tclin)
UniProt: P31645 B2R7Y7
Structure
PDB: 

Position
17q11.2
AA seq 630 aa
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
NT seq 1893 nt   +upstreamnt  +downstreamnt
atggagacgacgcccttgaattctcagaagcagctatcagcgtgtgaagatggagaagat
tgtcaggaaaacggagttctacagaaggttgttcccaccccaggggacaaagtggagtcc
gggcaaatatccaatgggtactcagcagttccaagtcctggtgcgggagatgacacacgg
cactctatcccagcgaccaccaccaccctagtggctgagcttcatcaaggggaacgggag
acctggggcaagaaggtggatttccttctctcagtgattggctatgctgtggacctgggc
aatgtctggcgcttcccctacatatgttaccagaatggagggggggcattcctcctcccc
tacaccatcatggccatttttgggggaatcccgctcttttacatggagctcgcactggga
cagtaccaccgaaatggatgcatttcaatatggaggaaaatctgcccgattttcaaaggg
attggttatgccatctgcatcattgccttttacattgcttcctactacaacaccatcatg
gcctgggcgctatactacctcatctcctccttcacggaccagctgccctggaccagctgc
aagaactcctggaacactggcaactgcaccaattacttctccgaggacaacatcacctgg
accctccattccacgtcccctgctgaagaattttacacgcgccacgtcctgcagatccac
cggtctaaggggctccaggacctggggggcatcagctggcagctggccctctgcatcatg
ctgatcttcactgttatctacttcagcatctggaaaggcgtcaagacctctggcaaggtg
gtgtgggtgacagccaccttcccttatatcatcctttctgtcctgctggtgaggggtgcc
accctccctggagcctggaggggtgttctcttctacttgaaacccaattggcagaaactc
ctggagacaggggtgtggatagatgcagccgctcagatcttcttctctcttggtccgggc
tttggggtcctgctggcttttgctagctacaacaagttcaacaacaactgctaccaagat
gccctggtgaccagcgtggtgaactgcatgacgagcttcgtttcgggatttgtcatcttc
acagtgctcggttacatggctgagatgaggaatgaagatgtgtctgaggtggccaaagac
gcaggtcccagcctcctcttcatcacgtatgcagaagcgatagccaacatgccagcgtcc
actttctttgccatcatcttctttctgatgttaatcacgctgggcttggacagcacgttt
gcaggcttggagggggtgatcacggctgtgctggatgagttcccacacgtctgggccaag
cgccgggagcggttcgtgctcgccgtggtcatcacctgcttctttggatccctggtcacc
ctgacttttggaggggcctacgtggtgaagctgctggaggagtatgccacggggcccgca
gtgctcactgtcgcgctgatcgaagcagtcgctgtgtcttggttctatggcatcactcag
ttctgcagggacgtgaaggaaatgctcggcttcagcccggggtggttctggaggatctgc
tgggtggccatcagccctctgtttctcctgttcatcatttgcagttttctgatgagcccg
ccacaactacgacttttccaatataattatccttactggagtatcatcttgggttactgc
ataggaacctcatctttcatttgcatccccacatatatagcttatcggttgatcatcact
ccagggacatttaaagagcgtattattaaaagtattaccccagaaacaccaacagaaatt
ccttgtggggacatccgcttgaatgctgtgtaa

KEGG   Homo sapiens (human): 6534
Entry
6534              CDS       T01001                                 

Gene name
SLC6A7, PROT
Definition
(RefSeq) solute carrier family 6 member 7
  KO
K05040  solute carrier family 6 (neurotransmitter transporter, L-proline) member 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04721 Synaptic vesicle cycle
    6534 (SLC6A7)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6534 (SLC6A7)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6534 (SLC6A7)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6534
NCBI-ProteinID: NP_055043
OMIM: 606205
HGNC: 11054
Ensembl: ENSG00000011083
Vega: OTTHUMG00000130046
Pharos: Q99884(Tchem)
UniProt: Q99884
Position
5q32
AA seq 636 aa
MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV
WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA
AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP
LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG
KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG
VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA
KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR
PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ
RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGI
LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS
PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
NT seq 1911 nt   +upstreamnt  +downstreamnt
atgaagaagctccagggagctcacctccgcaagcctgtcaccccagacctgctgatgacc
cccagtgaccagggcgatgtcgacctggatgtggactttgctgcacaccgggggaactgg
acaggcaagctggacttcctgctgtcctgcattggctactgtgtaggcctggggaatgtc
tggcgcttcccctatcgagcgtacaccaatggaggaggcgccttcctcgtgccctacttc
ctcatgctggccatctgtggcatccccctcttcttcctggagctctccctgggccagttc
tccagcctagggcccctggctgtctggaaaatcagccctctcttcaaaggcgccggcgca
gccatgctgctcatcgtgggcttggtggccatctactacaacatgatcatcgcctacgtg
ctcttctacctcttcgcctccctcaccagcgacctaccctgggagcactgtggcaactgg
tggaacacagaactctgcctggagcacagagtctccaaggacggcaacggggccctgccc
ctcaacctcacctgcaccgtcagccccagcgaggagtactggagccgctacgtcctccac
atccaaggcagccagggcatcggcagccctggggagatccgctggaacctctgcctctgc
ctgctgctggcctgggtcatcgtgttcctctgtatcctcaagggtgtgaagtcttcgggc
aaggtggtgtatttcacggccacgttcccctacctcatcctgctcatgctgctggtccgc
ggagtcaccctcccaggggcctggaagggcatccagttctatctcaccccccagttccac
cacttgttgtcttccaaggtgtggattgaagctgctcttcagatcttctattccctgggt
gtgggcttcggggggctcctcacctttgcctcctacaacacgtttcaccagaacatctat
agagacactttcatcgtcactctgggcaacgccatcaccagcatcctggctggctttgcc
atcttctccgtgctgggctacatgtctcaggagctgggcgtgcctgtggaccaagtagcc
aaagcaggccctggcctggcctttgtcgtctacccacaggccatgaccatgctgcctctg
tcacccttctggtcctttctcttcttcttcatgcttctgactctcggcctagatagccag
tttgcttttctggagaccattgtgacagctgtgacagatgagttcccatactacctgcgg
cccaagaaggcggtgttctcagggctcatctgcgtggccatgtacctgatggggctgatc
ctcaccactgatgggggcatgtactggctggtccttctggatgactacagcgccagcttc
gggctgatggtggtggttatcaccacgtgccttgccgtgacacgggtgtatggcattcag
aggttctgccgagacatccacatgatgctgggcttcaagccgggcctctacttcagggcc
tgctggctgttcctgtccccagccacgctcttggccctcatggtgtatagcatcgtcaag
taccagccctcggagtatggcagttaccgcttcccgccctgggctgagctgctgggcatc
ctgatgggcctgctgtcctgcctcatgatcccagctggcatgctggtggctgtgcttcga
gaagagggctcactctgggagcggctccaacaggccagccggccggccatggactgggga
ccatcgctggaggagaaccggacgggcatgtatgtggccacgctggctgggagccagtca
ccaaagccactgatggtgcacatgcgcaagtacgggggcatcaccagcttcgagaacacg
gccatcgaggtggaccgtgagattgcagaggaggaggagtcgatgatgtga

KEGG   Homo sapiens (human): 6536
Entry
6536              CDS       T01001                                 

Gene name
SLC6A9, GCENSG, GLYT1
Definition
(RefSeq) solute carrier family 6 member 9
  KO
K05038  solute carrier family 6 (neurotransmitter transporter, glycine) member 5/9
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
Disease
H02419  Glycine encephalopathy with normal serum glycine
Drug target
Bitopertin: D10186
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04721 Synaptic vesicle cycle
    6536 (SLC6A9)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6536 (SLC6A9)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6536 (SLC6A9)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6536
NCBI-ProteinID: NP_964012
OMIM: 601019
HGNC: 11056
Ensembl: ENSG00000196517
Vega: OTTHUMG00000008294
Pharos: P48067(Tchem)
UniProt: P48067
Position
1p34.1
AA seq 706 aa
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
NT seq 2121 nt   +upstreamnt  +downstreamnt
atgagcggcggagacacgcgggctgcgatcgctcgccccaggatggccgcggctcatgga
cctgtggccccctcttccccagaacaggtgacgcttctccctgttcagagatccttcttc
ctgccacccttttctggagccactccctctacttccctagcagagtctgtcctcaaagtc
tggcatggggcctacaactctggtctccttccccaactcatggcccagcactccctagcc
atggcccagaatggtgctgtgcccagcgaggccaccaagagggaccagaacctcaaacgg
ggcaactggggcaaccagatcgagtttgtactgacgagcgtgggctatgccgtgggcctg
ggcaatgtctggcgcttcccatacctctgctatcgcaacgggggaggcgccttcatgttc
ccctacttcatcatgctcatcttctgcgggatccccctcttcttcatggagctctccttc
ggccagtttgcaagccaggggtgcctgggggtctggaggatcagccccatgttcaaagga
gtgggctatggtatgatggtggtgtccacctacatcggcatctactacaatgtggtcatc
tgcatcgccttctactacttcttctcgtccatgacgcacgtgctgccctgggcctactgc
aataacccctggaacacgcatgactgcgccggtgtactggacgcctccaacctcaccaat
ggctctcggccagccgccttgcccagcaacctctcccacctgctcaaccacagcctccag
aggaccagccccagcgaggagtactggaggctgtacgtgctgaagctgtcagatgacatt
gggaactttggggaggtgcggctgcccctccttggctgcctcggtgtctcctggttggtc
gtcttcctctgcctcatccgaggggtcaagtcttcagggaaagtggtgtacttcacggcc
acgttcccctacgtggtgctgaccattctgtttgtccgcggagtgaccctggagggagcc
tttgacggcatcatgtactacctaaccccgcagtgggacaagatcctggaggccaaggtg
tggggtgatgctgcctcccagatcttctactcactgggctgcgcgtggggaggcctcatc
accatggcttcctacaacaagttccacaataactgttaccgggacagtgtcatcatcagc
atcaccaactgtgccaccagcgtctatgctggcttcgtcatcttctccatcctcggcttc
atggccaatcacctgggcgtggatgtgtcccgtgtggcagaccacggccctggcctggcc
ttcgtggcttaccccgaggccctcacactacttcccatctccccgctgtggtctctgctc
ttcttcttcatgcttatcctgctggggctgggcactcagttctgcctcctggagacgctg
gtcacagccattgtggatgaggtggggaatgagtggatcctgcagaaaaagacctatgtg
accttgggcgtggctgtggctggcttcctgctgggcatccccctcaccagccaggcaggc
atctattggctgctgctgatggacaactatgcggccagcttctccttggtggtcatctcc
tgcatcatgtgtgtggccatcatgtacatctacgggcaccggaactacttccaggacatc
cagatgatgctgggattcccaccacccctcttctttcagatctgctggcgcttcgtctct
cccgccatcatcttctttattctagttttcactgtgatccagtaccagccgatcacctac
aaccactaccagtacccaggctgggccgtggccattggcttcctcatggctctgtcctcc
gtcctctgcatccccctctacgccatgttccggctctgccgcacagacggggacaccctc
ctccagcgtttgaaaaatgccacaaagccaagcagagactggggccctgccctcctggag
caccggacagggcgctacgcccccaccatagccccctctcctgaggacggcttcgaggtc
cagccactgcacccggacaaggcgcagatccccattgtgggcagtaatggctccagccgc
ctccaggactcccggatatga

KEGG   Homo sapiens (human): 6538
Entry
6538              CDS       T01001                                 

Gene name
SLC6A11, GAT-3, GAT3, GAT4
Definition
(RefSeq) solute carrier family 6 member 11
  KO
K05044  solute carrier family 6 (neurotransmitter transporter, GABA) member 11
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04727  GABAergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    6538 (SLC6A11)
   04721 Synaptic vesicle cycle
    6538 (SLC6A11)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6538 (SLC6A11)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6538 (SLC6A11)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6538
NCBI-ProteinID: NP_055044
OMIM: 607952
HGNC: 11044
Ensembl: ENSG00000132164
Vega: OTTHUMG00000129718
Pharos: P48066(Tbio)
UniProt: P48066
Position
3p25.3
AA seq 632 aa
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV
LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT
CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC
VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY
FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV
DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA
YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT
AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA
IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY
NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL
GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
NT seq 1899 nt   +upstreamnt  +downstreamnt
atgacggcggagaaggcgctgcccctgggcaatgggaaggctgctgaggaggcgcgggag
tccgaggcgccgggtggcggctgcagcagcgggggcgcggcgcccgcgcgccacccgcgc
gtcaagcgcgacaaggcggtccacgagcgcggccactggaacaacaaggtggagttcgtg
ctgagcgtggccggggagatcattgggctgggcaacgtgtggcgcttcccctacctgtgc
tacaagaacggaggaggggcattcctgattccctacgtggtgttttttatttgctgtgga
attcctgtttttttcctggagacagctctggggcagttcacaagtgaaggtggcattacg
tgttggaggaaagtttgccctttatttgaaggcattggctatgcaacacaggtgattgag
gcccatctgaatgtgtactacatcatcatcctggcatgggccattttttacctgagcaac
tgcttcactactgagctaccctgggctacctgtgggcatgagtggaacacagagaattgt
gtggagttccagaaactgaatgtgagcaactacagccatgtgtctctgcagaatgccacc
tcccctgtcatggagttttgggagcaccgggtcctggccatctctgacgggatcgagcac
atcgggaaccttcgctgggagctggccttgtgtctcttggcagcctggaccatctgttac
ttctgtatctggaaggggaccaagtctacaggaaaggttgtatacgtgactgcgacattc
ccctacatcatgctgctgatcctcctgatacgaggggtcacgttgcccggggcctcagag
ggcatcaagttctacttgtaccctgacctctcccggctctccgacccccaggtctgggta
gatgctggaacgcagatctttttctcctatgccatttgcctgggctgtctgaccgctctg
ggaagttataacaattataacaacaactgctacagggactgcatcatgctctgttgcctg
aacagcggcaccagcttcgtggctgggtttgccatcttctcagtcctgggttttatggcg
tacgagcagggggtacccattgctgaggtggcagagtcaggccccggcctggcctttatt
gcgtaccccaaggcggtcaccatgatgcctctctccccgctgtgggccaccttgttcttc
atgatgctcatcttcctgggcctggacagccagtttgtgtgtgtggaaagcctggtgacc
gccgtggtggacatgtaccccaaggttttccggaggggttaccggcgggagctgctcatc
ctagccttgtctgttatctcctattttctgggcctcgtgatgttaacagagggtggcatg
tacatcttccagctctttgactcctatgccgccagtgggatgtgccttctcttcgtggcc
atctttgagtgcatctgcatcggctgggtgtatggaagcaaccggttctatgataacatt
gaagacatgattggctaccggccaccgtcgctcattaagtggtgctggatgatcatgacc
cctgggatctgcgcggggatcttcatcttcttcttgatcaagtacaagccactcaagtac
aacaacatctacacctacccagcctggggctatggcattggctggctcatggccctgtcc
tccatgctctgcatcccgctctggatctgcatcacagtgtggaagacggaggggacactg
cccgagaaactccagaagttgacgacccccagcacagatctgaaaatgcggggcaagctt
ggggtgagcccacggatggtgacagttaatgactgtgatgccaaactcaagagtgacggg
accatcgcagccatcacagagaaggagacgcacttctga

KEGG   Homo sapiens (human): 6539
Entry
6539              CDS       T01001                                 

Gene name
SLC6A12, BGT-1, BGT1, GAT2
Definition
(RefSeq) solute carrier family 6 member 12
  KO
K05045  solute carrier family 6 (neurotransmitter transporter, betaine/GABA) member 12
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04727  GABAergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    6539 (SLC6A12)
   04721 Synaptic vesicle cycle
    6539 (SLC6A12)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6539 (SLC6A12)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6539 (SLC6A12)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6539
NCBI-ProteinID: NP_001116319
OMIM: 603080
HGNC: 11045
Ensembl: ENSG00000111181
Vega: OTTHUMG00000090309
Pharos: P48065(Tchem)
UniProt: P48065
Position
12p13.33
AA seq 614 aa
MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGL
ASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTP
FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY
FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR
RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR
FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW
FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP
TREGLIAGEKETHL
NT seq 1845 nt   +upstreamnt  +downstreamnt
atggacgggaaggtggcagtgcaagagtgtgggcctcctgcagtctcctgggtccccgag
gagggagagaagttggaccaggaagacgaggaccaggtgaaggatcggggccaatggacc
aacaagatggagtttgtgctgtcagtggccggggagatcattgggctgggcaatgtctgg
aggtttccctatctctgctacaaaaacggaggtggagccttcttcatcccctacttcatc
ttcttctttgtctgcggcatcccggtgttcttcctggaggtggcgttgggccaatacacc
agccaagggagtgtcacagcctggaggaagatctgccccctcttccagggcattggtctg
gcatctgtggtcatcgagtcatatttgaatgtctactacatcatcatccttgcctgggct
ctcttctacctgttcagctccttcacttctgagctgccctggacgacctgcaacaacttt
tggaacacagagcattgcacggactttctgaaccactcaggagccggcacagtgacccca
tttgagaattttacctcacctgtcatggaattctgggagagacgagttctgggcatcacc
tcgggcatccatgacctgggctccctgcgctgggagctggccctgtgcctcctgctcgcc
tgggtcatctgctatttctgcatctggaagggggtcaagtccacaggcaaggtggtttat
ttcacagccacgtttccgtacctgatgcttgtcattttgctgatcagaggtgtcaccctt
cccggagcctaccagggcatcatctactacttgaagccagatttgttccgcctcaaggac
cctcaggtgtggatggatgcgggcacccagatcttcttctcctttgccatctgccagggg
tgcctgacagccctgggcagctacaacaagtatcacaacaactgctacaaggactgcatc
gccctctgcttcctgaacagtgccaccagctttgtggctgggtttgttgtcttctccatc
ctgggcttcatgtcccaagagcaaggggtgcccatttctgaagtggccgagtcaggtcct
gggctggccttcatcgccttccccaaggctgtgactatgatgcccttatcccagctgtgg
tcctgcctgttctttatcatgctcatattcctagggctggacagccagtttgtctgtgtg
gagtgcctggtgacagcctccatagacatgttccccaggcagctccggaagagcgggcgg
cgcgagctcctcatcctcaccatcgccgtcatgtgctacctgatagggcttttcctggtc
accgagggcgggatgtacatcttccagctgtttgactactatgcttccagtggcatatgc
ctgctgttcctgtcattgtttgaagtggtctgcataagctgggtgtatggggcggaccgt
ttctatgacaacattgaggacatgattggctaccggccatggcccctggtgaagatctcc
tggctcttcctgacccctggactttgcctggccactttcctcttctccttgagcaagtac
acccccctcaagtacaacaacgtctatgtgtacccgccctggggatactccattggctgg
ttcctggctctgtcctccatggtctgtgtcccactcttcgtcgtcatcaccctcctgaag
actcggggtcctttcaggaagcgtctgcgtcagctcatcacccctgactccagtctgcca
cagcccaagcaacatccctgcttggatggcagtgctggccggaactttgggccctcccca
acaagggaaggactgatagccggggagaaggagacccatttgtag

KEGG   Homo sapiens (human): 6540
Entry
6540              CDS       T01001                                 

Gene name
SLC6A13, GAT-2, GAT2, GAT3
Definition
(RefSeq) solute carrier family 6 member 13
  KO
K05046  solute carrier family 6 (neurotransmitter transporter, GABA) member 13
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04727  GABAergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    6540 (SLC6A13)
   04721 Synaptic vesicle cycle
    6540 (SLC6A13)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6540 (SLC6A13)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6540 (SLC6A13)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6540
NCBI-ProteinID: NP_057699
OMIM: 615097
HGNC: 11046
Ensembl: ENSG00000010379
Vega: OTTHUMG00000168053
Pharos: Q9NSD5(Tbio)
UniProt: Q9NSD5
Position
12p13.33
AA seq 602 aa
MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQM
IVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENAT
SPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLI
LGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNI
EDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELES
HC
NT seq 1809 nt   +upstreamnt  +downstreamnt
atggatagcagggtctcaggcacaaccagtaatggagagacaaaaccagtgtatccagtc
atggaaaagaaggaggaagatggcaccctggagcgggggcactggaacaacaagatggag
tttgtgctgtcagtggctggggagatcattggcttaggcaacgtctggaggtttccctat
ctctgctacaaaaatgggggaggtgccttcttcatcccctacctcgtcttcctctttacc
tgtggcattcctgtcttccttctggagacagcactaggccagtacactagccagggaggc
gtcacagcctggaggaagatctgccccatctttgagggcattggctatgcctcccagatg
atcgtcatcctcctcaacgtctactacatcattgtgttggcctgggccctgttctacctc
ttcagcagcttcaccatcgacctgccctggggcggctgctaccatgagtggaacacagaa
cactgtatggagttccagaagaccaacggctccctgaatggtacctctgagaatgccacc
tctcctgtcatcgagttctgggagcggcgggtcttgaagatctctgatgggatccagcac
ctgggggccctgcgctgggagctggctctgtgcctcctgctggcctgggtcatctgctac
ttctgcatctggaagggggtgaagtccacaggcaaggtggtgtacttcacggccacattt
ccttacctcatgctggtggtcctgttaattcgaggggtgacgttgcctggggcagcccaa
ggaattcagttttacctgtacccaaacctcacgcgtctgtgggatccccaggtgtggatg
gatgcaggcacccagatattcttctccttcgccatctgtcttgggtgcctgacagccctg
ggcagctacaacaagtaccacaacaactgctacagggactgcatcgccctctgcttcctc
aacagcggcaccagctttgtggccggctttgccatcttctccatcctgggcttcatgtct
caggagcagggggtgcccatttctgaggtggccgagtcaggccctggcctggctttcatc
gcttacccgcgggctgtggtgatgctgcccttctctcctctctgggcctgctgtttcttc
ttcatggtcgttctcctgggactggatagccagtttgtgtgtgtagaaagcctggtgaca
gcgctggtggacatgtaccctcacgtgttccgcaagaagaaccggagggaagtcctcatc
cttggagtatctgtcgtctccttccttgtggggctgatcatgctcacagagggcggaatg
tacgtgttccagctctttgactactatgcggccagtggcatgtgcctcctgttcgtggcc
atcttcgagtccctctgtgtggcttgggtttacggagccaagcgcttctacgacaacatc
gaagacatgattgggtacaggccatggcctcttatcaaatactgttggctcttcctcaca
ccagctgtgtgcacagccacctttctcttctccctgataaagtacactccgctgacctac
aacaagaagtacacgtacccgtggtggggcgatgccctgggctggctcctggctctgtcc
tccatggtctgcattcctgcctggagcctctacagactcggaaccctcaagggccccttc
agagagagaatccgtcagctcatgtgcccagccgaggacctgccccagcggaacccagca
ggaccctcggctcccgccacccccaggacctcactgctcagactcacagagctagagtct
cactgctag

KEGG   Homo sapiens (human): 9152
Entry
9152              CDS       T01001                                 

Gene name
SLC6A5, GLYT-2, GLYT2, HKPX3, NET1
Definition
(RefSeq) solute carrier family 6 member 5
  KO
K05038  solute carrier family 6 (neurotransmitter transporter, glycine) member 5/9
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
Disease
H00769  Hyperekplexia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04721 Synaptic vesicle cycle
    9152 (SLC6A5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    9152 (SLC6A5)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   9152 (SLC6A5)
SSDB
Motif
Pfam: SNF DUF999
Other DBs
NCBI-GeneID: 9152
NCBI-ProteinID: NP_004202
OMIM: 604159
HGNC: 11051
Ensembl: ENSG00000165970
Vega: OTTHUMG00000166024
Pharos: Q9Y345(Tchem)
UniProt: Q9Y345 Q4VAM6 Q4VAM4
Position
11p15.1
AA seq 797 aa
MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
NT seq 2394 nt   +upstreamnt  +downstreamnt
atggattgcagtgctcccaaggaaatgaataaactgccagccaacagcccggaggcggcg
gcggcgcagggccacccggatggcccatgcgctcccaggacgagcccggagcaggagctt
cccgcggctgccgccccgccgccgccacgtgtgcccaggtccgcttccaccggcgcccaa
actttccagtcagcggacgcgcgagcctgcgaggctgagcggccaggagtggggtcttgc
aaactcagtagcccgcgggcgcaggcggcctctgcagctctgcgggacttgagagaggcg
caaggcgcgcaggcctcgccccctcccgggagctccgggcccggcaacgcgctgcactgt
aagatcccttttctgcgaggcccggagggggatgcgaacgtgagtgtgggcaagggcacc
ctggagcggaacaatacccctgttgtgggctgggtgaacatgagccagagcaccgtggtg
ctggccacggatggaatcacgtccgtgctcccgggcagcgtggccaccgttgccacccag
gaggacgagcaaggggatgagaataaggcccgagggaactggtccagcaaactggacttc
atcctgtccatggtggggtacgcagtggggctgggcaatgtctggaggtttccctacctg
gccttccagaacgggggaggtgctttcctcatcccttacctgatgatgctggctctggct
ggattacccatcttcttcttggaggtgtcgctgggccagtttgccagccagggaccagtg
tctgtgtggaaggccatcccagctctacaaggctgtggcatcgcgatgctgatcatctct
gtcctaatagccatatactacaatgtgattatttgctatacacttttctacctgtttgcc
tcctttgtgtctgtactaccctggggctcctgcaacaacccttggaatacgccagaatgc
aaagataaaaccaaacttttattagattcctgtgttatcagtgaccatcccaaaatacag
atcaagaactcgactttctgcatgaccgcttatcccaacgtgacaatggttaatttcacc
agccaggccaataagacatttgtcagtggaagtgaagagtacttcaagtactttgtgctg
aagatttctgcagggattgaatatcctggcgagatcaggtggccactagctctctgcctc
ttcctggcttgggtcattgtgtatgcatcattggctaaaggaatcaagacttcaggaaaa
gtggtgtacttcacggccacgttcccgtatgtcgtactcgtgatcctcctcatccgagga
gtcaccctgcctggagctggagctgggatctggtacttcatcacacccaagtgggagaaa
ctcacggatgccacggtgtggaaagatgctgccactcagattttcttctctttatctgct
gcatggggaggcctgatcactctctcttcttacaacaaattccacaacaactgctacagg
gacactctaattgtcacctgcaccaacagtgccacaagcatctttgccggcttcgtcatc
ttctccgttatcggcttcatggccaatgaacgcaaagtcaacattgagaatgtggcagac
caagggccaggcattgcatttgtggtttacccggaagccttaaccaggctgcctctctct
ccgttctgggccatcatctttttcctgatgctcctcactcttggacttgacactatgttt
gccaccatcgagaccatagtgacctccatctcagacgagtttcccaagtacctacgcaca
cacaagccagtgtttactctgggctgctgcatttgtttcttcatcatgggttttccaatg
atcactcagggtggaatttacatgtttcagcttgtggacacctatgctgcctcctatgcc
cttgtcatcattgccatttttgagctcgtggggatctcttatgtgtatggcttgcaaaga
ttctgtgaagatatagagatgatgattggattccagcctaacatcttctggaaagtctgc
tgggcatttgtaaccccaaccattttaacctttatcctttgcttcagcttttaccagtgg
gagcccatgacctatggctcttaccgctatcctaactggtccatggtgctcggatggcta
atgctcgcctgttccgtcatctggatcccaattatgtttgtgataaaaatgcatctggcc
cctggaagatttattgagaggctgaagttggtgtgctcgccacagccggactggggccca
ttcttagctcaacaccgcggggagcgttacaagaacatgatcgaccccttgggaacctct
tccttgggactcaaactgccagtgaaggatttggaactgggcactcagtgctag

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