KEGG   Homo sapiens (human): 6507Help
Entry
6507              CDS       T01001                                 

Gene name
SLC1A3, EA6, EAAT1, GLAST, GLAST1
Definition
(RefSeq) solute carrier family 1 member 3
  KO
K05614  solute carrier family 1 (glial high affinity glutamate transporter), member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04724  Glutamatergic synapse
hsa05016  Huntington disease
Disease
H00749  Episodic ataxias
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    6507 (SLC1A3)
   04721 Synaptic vesicle cycle
    6507 (SLC1A3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    6507 (SLC1A3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6507 (SLC1A3)
   04147 Exosome [BR:hsa04147]
    6507 (SLC1A3)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC1: High-affinity glutamate and neutral amino acid transporter
   6507 (SLC1A3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of cortical neuronal cells
   6507 (SLC1A3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: SDF MT
Motif
Other DBs
NCBI-GeneID: 6507
NCBI-ProteinID: NP_004163
OMIM: 600111
HGNC: 10941
Ensembl: ENSG00000079215
Vega: OTTHUMG00000090793
Pharos: P43003(Tchem)
UniProt: P43003 Q8N169 A0A024R050
Position
5p13.2
AA seq 542 aa AA seqDB search
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
NT seq 1629 nt NT seq  +upstreamnt  +downstreamnt
atgactaaaagcaatggagaagagcccaagatggggggcaggatggagagattccagcag
ggagtccgtaaacgcacacttttggccaagaagaaagtgcagaacattacaaaggaggat
gttaaaagttacctgtttcggaatgcttttgtgctgctcacagtcaccgctgtcattgtg
ggtacaatccttggatttaccctccgaccatacagaatgagctaccgggaagtcaagtac
ttctcctttcctggggaacttctgatgaggatgttacagatgctggtcttaccacttatc
atctccagtcttgtcacaggaatggcggcgctagatagtaaggcatcagggaagatggga
atgcgagctgtagtctattatatgactaccaccatcattgctgtggtgattggcataatc
attgtcatcatcatccatcctgggaagggcacaaaggaaaacatgcacagagaaggcaaa
attgtacgagtgacagctgcagatgccttcctggacttgatcaggaacatgttccctcca
aatctggtagaagcctgctttaaacagtttaaaaccaactatgagaagagaagctttaaa
gtgcccatccaggccaacgaaacgcttgtgggtgctgtgataaacaatgtgtctgaggcc
atggagactcttacccgaatcacagaggagctggtcccagttccaggatctgtgaatgga
gtcaatgccctgggtctagttgtcttctccatgtgcttcggttttgtgattggaaacatg
aaggaacaggggcaggccctgagagagttctttgattctcttaacgaagccatcatgaga
ctggtagcagtaataatgtggtatgcccccgtgggtattctcttcctgattgctgggaag
attgtggagatggaagacatgggtgtgattggggggcagcttgccatgtacaccgtgact
gtcattgttggcttactcattcacgcagtcatcgtcttgccactcctctacttcttggta
acacggaaaaacccttgggtttttattggagggttgctgcaagcactcatcaccgctctg
gggacctcttcaagttctgccaccctacccatcaccttcaagtgcctggaagagaacaat
ggcgtggacaagcgcgtcaccagattcgtgctccccgtaggagccaccattaacatggat
gggactgccctctatgaggctttggctgccattttcattgctcaagttaacaactttgaa
ctgaacttcggacaaattattacaatcagcatcacagccacagctgccagtattggggca
gctggaattcctcaggcgggcctggtcactatggtcattgtgctgacatctgtcggcctg
cccactgacgacatcacgctcatcatcgcggtggactggttcctggatcgcctccggacc
accaccaacgtactgggagactccctgggagctgggattgtggagcacttgtcacgacat
gaactgaagaacagagatgttgaaatgggtaactcagtgattgaagagaatgaaatgaag
aaaccatatcaactgattgcacaggacaatgaaactgagaaacccatcgacagtgaaacc
aagatgtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (13)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (39)   
   RefSeq(nuc) (9)   
   GenBank (15)   
   EMBL (15)   
Protein domain (2)   
   Pfam (2)   
All databases (77)   

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