KEGG   Homo sapiens (human): 6523
Entry
6523              CDS       T01001                                 
Symbol
SLC5A1, D22S675, NAGT, SGLT-1, SGLT1
Name
(RefSeq) solute carrier family 5 member 1
  KO
K14158  solute carrier family 5 (sodium/glucose cotransporter), member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04973  Carbohydrate digestion and absorption
hsa04976  Bile secretion
hsa04978  Mineral absorption
Disease
H01261  Congenital glucose-galactose malabsorption
Drug target
Sotagliflozin: D10669<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    6523 (SLC5A1)
   04973 Carbohydrate digestion and absorption
    6523 (SLC5A1)
   04978 Mineral absorption
    6523 (SLC5A1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6523 (SLC5A1)
   04147 Exosome [BR:hsa04147]
    6523 (SLC5A1)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC5: Sodium glucose cotransporter
   6523 (SLC5A1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   6523 (SLC5A1)
SSDB
Motif
Pfam: SSF TadF
Other DBs
NCBI-GeneID: 6523
NCBI-ProteinID: NP_000334
OMIM: 182380
HGNC: 11036
Ensembl: ENSG00000100170
UniProt: P13866
Structure
Position
22:32043261..32113029
AA seq 664 aa
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
NT seq 1995 nt   +upstreamnt  +downstreamnt
atggacagtagcacctggagccccaagaccaccgcggtcacccggcctgttgagacccac
gagctcattcgcaatgcagccgatatctccatcatcgttatctacttcgtggtagtgatg
gccgtcggactgtgggctatgttttccaccaatcgtgggactgttggaggcttcttcctg
gcaggccgaagtatggtgtggtggccgattggagcctccctctttgctagtaacattgga
agtggccactttgtggggctggccgggactggggcagcttcaggcatcgccattggaggc
tttgaatggaatgccctggttttggtggttgtgctgggctggctgtttgtccccatctat
attaaggctggggtggtgacaatgccagagtacctgaggaagcggtttggaggccagcgg
atccaggtctacctttcccttctgtccctgctgctctacattttcaccaagatctcggca
gacatcttctcgggggccatattcatcaatctggccttaggcctgaatctgtatttagcc
atctttctcttattggcaatcactgccctttacacaattacagggggcctggcggcggtg
atttacacggacaccttgcagacggtgatcatgctggtggggtctttaatcctgactggg
tttgcttttcacgaagtgggaggctatgacgccttcatggaaaagtacatgaaagccatt
ccaaccatagtgtctgatggcaacaccacctttcaggaaaaatgctacactccaagggcc
gactccttccacatcttccgagatcccctcacgggagacctcccatggcctgggttcatc
tttgggatgtccatccttaccttgtggtactggtgcacagatcaggtcattgtgcagcgc
tgcctctcagccaagaatatgtctcacgtgaagggtggctgcatcctgtgtgggtatcta
aagctgatgcccatgttcatcatggtgatgccaggaatgatcagccgcattctgtacaca
gaaaaaattgcctgtgtcgtcccttcagaatgtgagaaatattgcggtaccaaggttggc
tgtaccaacatcgcctatccaaccttagtggtggagctcatgcccaatggactgcgaggc
ctgatgctatcagtcatgctggcctccctcatgagctccctgacctccatcttcaacagc
gccagcaccctcttcaccatggacatctacgccaaggtccgcaagagagcatctgagaaa
gagctcatgattgccggaaggttgtttatcctggtgctgattggcatcagcatcgcctgg
gtgcccattgtgcagtcagcacaaagtgggcaactcttcgattacatccagtccatcacc
agttacttgggaccacccattgcggctgtcttcctgcttgctattttctggaagagagtc
aatgagccaggagccttttggggactgatcctaggacttctgattgggatttcacgtatg
attactgagtttgcttatggaaccgggagctgcatggagcccagcaactgtcccacgatt
atctgtggggtgcactacttgtactttgccattatcctcttcgccatttctttcatcacc
atcgtggtcatctccctcctcaccaaacccattccggatgtgcatctctaccgtctgtgt
tggagcctgcgcaacagcaaagaggagcgtattgacctggatgcggaagaggagaacatc
caagaaggccctaaggagaccattgaaatagaaacacaagttcctgagaagaaaaaagga
atcttcaggagagcctatgacctattttgtgggctagagcagcacggtgcacccaagatg
actgaggaagaggagaaagccatgaagatgaagatgacggacacctctgagaagcctttg
tggaggacagtgttgaacgtcaatggcatcatcctggtgaccgtggctgtcttttgccat
gcatattttgcctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (11)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (26)   
   RefSeq(nuc) (4)   
   GenBank (11)   
   EMBL (11)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   Pfam (2)   
All databases (51)   

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