KEGG   Homo sapiens (human): 6530
Entry
6530              CDS       T01001                                 
Symbol
SLC6A2, NAT1, NET, NET1, SLC6A5
Name
(RefSeq) solute carrier family 6 member 2
  KO
K05035  solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
Disease
H01031  Orthostatic intolerance
Drug target
Amezinium metilsulfate: D01304<JP>
Amfepramone (DG00104): D03801<US> D07444
Amfetamine (DG00966): D02074<US> D07445<US>
Amitifadine (DG01386): D10088 D10089
Amitriptyline (DG00934): D00809<JP/US> D07448
Amitriptylinoxide: D07449
Amoxapine: D00228<JP/US>
Amphetamine aspartate monohydrate: D11622
Ampreloxetine (DG03081): D11688 D11689
Atomoxetine (DG00970): D02574<JP/US> D07473
Benzfetamine (DG01755): D07514 D07515<US>
Bupropion (DG00957): D00817<US> D07591 D07938<US>
Centanafadine (DG01858): D10697 D10698
Cidoxepin hydrochloride: D03491
Clomipramine (DG00929): D00811<JP/US> D07727
Cocaine (DG00808): D00110 D02182<US>
Dasotraline (DG01989): D10700 D10870
Desipramine (DG00927): D00812<US> D07791
Desvenlafaxine (DG00963): D02570<US> D07793<US> D11619<US>
Dexamfetamine (DG00967): D02078<US> D03740<US>
Dexmethylphenidate (DG00972): D03721<US> D07806
Dextroamphetamine saccharate: D11623
Dosulepin (DG00940): D01546<JP> D07872
Doxepin (DG00937): D00814<US> D07875
Duloxetine (DG00962): D01179<JP/US> D07880
Edivoxetine (DG01310): D09890 D09891
Esreboxetine (DG01309): D09340 D09341
Guanethidine (DG00258): D02237 D04382 D08030
Hydroxyamphetamine hydrobromide: D04473
Imipramine (DG00928): D00815<JP/US> D08070 D08071<US>
Imipraminoxide (DG01542): D07334 D08072
Indeloxazine (DG02869): D02170 D08077
Levomilnacipran (DG01387): D10072 D10133<US>
Liafensine: D10443
Lisdexamfetamine (DG00973): D04747<JP/US> D08130
Lofepramine (DG00932): D01285<JP> D08140
Lortalamine: D04781
Maprotiline (DG00941): D00818<JP> D02566
Mazindol: D00367<JP>
Metamfetamine (DG00968): D02242<JP/US> D08187
Methylphenidate (DG00969): D01296<JP/US> D04999<US>
Midomafetamine: D11172
Milnacipran (DG00960): D01107<JP/US> D08222
Napamezole hydrochloride: D05119
Napitane mesylate: D05120
Nisoxetine: D05173
Nomifensine: D05200
Nortriptyline (DG00935): D00816<JP/US> D08288
Oxaprotiline hydrochloride: D05284
Phendimetrazine (DG01537): D02080<US> D08347 D08348
Phenmetrazine hydrochloride: D05454
Phentermine (DG00102): D05458 D05459<US>
Protriptyline (DG00936): D00484<US> D08447
Pyrovalerone hydrochloride: D05663
Radafaxine hydrochloride: D05692
Reboxetine (DG00961): D02573 D08472
Sibutramine (DG00108): D02571 D08513
Solriamfetol (DG02989): D11315 D11328<US>
Talopram hydrochloride: D05997
Tampramine fumarate: D02704
Tandamine hydrochloride: D06004
Tapentadol (DG00826): D06007 D10199<JP/US>
Toludesvenlafaxine (DG03141): D11940 D11941
Trimipramine (DG00931): D00394 D02408<JP/US>
Venlafaxine (DG00959): D00821<JP/US> D08670 D12403<US>
Viloxazine (DG00956): D02572<US> D08673
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04721 Synaptic vesicle cycle
    6530 (SLC6A2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6530 (SLC6A2)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6530 (SLC6A2)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6530
NCBI-ProteinID: NP_001034
OMIM: 163970
HGNC: 11048
Ensembl: ENSG00000103546
UniProt: P23975 A0A024R6T9
Position
16:55655988..55706192
AA seq 617 aa
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
NT seq 1854 nt   +upstreamnt  +downstreamnt
atgcttctggcgcggatgaacccgcaggtgcagcccgagaacaacggggcggacacgggt
ccagagcagccccttcgggcgcgcaaaactgcggagctgctggtggtgaaggagcgcaac
ggcgtccagtgcctgctggcgccccgcgacggcgacgcgcagccccgggagacctggggc
aagaagatcgacttcctgctgtccgtagtcggcttcgcagtggacctggccaacgtgtgg
cgcttcccctacctctgctacaagaacggcggcggtgccttcttgatcccgtacacactg
ttccttatcatcgcggggatgcccctgttctacatggagctggctctgggacagtacaac
cgggagggggctgccaccgtttggaaaatctgcccattcttcaaaggcgttggctatgct
gtcatcctgatcgccctgtacgttggcttctactacaacgtcatcatcgcctggtcactc
tactacctcttctcctccttcaccctcaacctgccctggaccgactgtggccacacctgg
aacagccccaactgtaccgaccccaagctcctcaatggctccgtgcttggcaaccacacc
aagtactccaagtacaagttcacgccggcagccgagttttatgagcgtggtgtcctgcac
cttcacgagagcagcgggattcatgacatcggcctgccccagtggcagctcttgctctgt
ctgatggtcgtcgtcatcgtcttgtattttagcctctggaaaggggtgaagacatcagga
aaggtggtgtggatcacagccacgctgccttacttcgtgctgttcgtgctcctggtccat
ggcgtcacgctgcccggagcctccaatggcatcaatgcctacctgcacatcgacttctac
cgcttgaaagaggccacggtatggattgatgccgcaactcagatatttttttccttgggg
gctggatttggagtattgattgcatttgccagttacaacaaatttgacaacaactgttac
agggatgccctgctgaccagcagcatcaactgtatcaccagcttcgtctctgggttcgcc
atcttctccatccttggttacatggcccatgaacacaaggtcaacattgaggatgtggcc
acagaaggagctggcctagtgttcatcctgtatccagaggccatttctaccctgtctgga
tctacattctgggctgttgtgtttttcgtcatgctcctggcgctgggccttgacagctca
atgggaggcatggaggctgtcatcacgggcctggcagatgacttccaggtcctgaagcga
caccggaaactcttcacatttggcgtcaccttcagcactttccttctcgccctgttctgc
ataaccaagggtggaatttacgtcttgaccctcctggacacctttgctgcgggcacctcc
atcctttttgctgtcctcatggaagccatcggagtttcctggttttatggagtggacagg
ttcagcaacgacatccagcagatgatggggttcaggccgggtctatactggagactgtgc
tggaagttcgtcagtcctgccttcctcctgttcgtggttgtggtcagcatcatcaacttc
aagccactcacctacgacgactacatcttcccgccctgggccaactgggtggggtggggc
atcgccctgtcctccatggtcctggtgcccatctacgtcatctataagttcctcagcacg
cagggctctctttgggagagactggcctatggcatcacgccagagaacgagcaccacctg
gtggctcagagggacatcagacagttccagttgcaacactggctggccatctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (116)   
   KEGG DRUG (116)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (23)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (42)   
   RefSeq(nuc) (20)   
   GenBank (11)   
   EMBL (11)   
Protein domain (1)   
   Pfam (1)   
All databases (204)   

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