KEGG T01001: 6530

Homo sapiens (human): 6530

Entry

6530              CDS       T01001

Symbol

SLC6A2, NAT1, NET, NET1, SLC6A5

Name

(RefSeq) solute carrier family 6 member 2

K05035

solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04082

Neuroactive ligand signaling

hsa04721

Synaptic vesicle cycle

Network

nt06544 Neuroactive ligand signaling

Element

N01920

Transport of norepinephrine into neuron

Disease

H01031

Orthostatic intolerance

Drug target

Amezinium metilsulfate:

D01304<JP>

Amfepramone (DG00104):

D03801<US> D07444

Amfetamine (DG00966):

D02074<US> D07445<US>

Amitifadine (DG01386):

D10088 D10089

Amitriptyline (DG00934):

D00809<JP/US> D07448

Amitriptylinoxide:

D07449

Amoxapine:

D00228<JP/US>

Amphetamine aspartate monohydrate:

D11622

Ampreloxetine (DG03081):

D11688 D11689

Atomoxetine (DG00970):

D02574<JP/US> D07473

Benzfetamine (DG01755):

D07514 D07515<US>

Bupropion (DG00957):

D00817<US> D07591 D07938<US>

Centanafadine (DG01858):

D10697 D10698

Cidoxepin hydrochloride:

D03491

Clomipramine (DG00929):

D00811<JP/US> D07727

Cocaine (DG00808):

D00110 D02182<US>

Dasotraline (DG01989):

D10700 D10870

Desipramine (DG00927):

D00812<US> D07791

Desvenlafaxine (DG00963):

D02570<US> D07793<US> D11619<US>

Dexamfetamine (DG00967):

D02078<US> D03740<US>

Dexmethylphenidate (DG00972):

D03721<US> D07806

Dextroamphetamine saccharate:

D11623

Dosulepin (DG00940):

D01546<JP> D07872

Doxepin (DG00937):

D00814<US> D07875

Duloxetine (DG00962):

D01179<JP/US> D07880

Edivoxetine (DG01310):

D09890 D09891

Esreboxetine (DG01309):

D09340 D09341

Guanethidine (DG00258):

D02237 D04382 D08030

Hydroxyamphetamine hydrobromide:

D04473

Imipramine (DG00928):

D00815<JP/US> D08070 D08071<US>

Imipraminoxide (DG01542):

D07334 D08072

Indeloxazine (DG02869):

D02170 D08077

Levomilnacipran (DG01387):

D10072 D10133<US>

Liafensine:

D10443

Lisdexamfetamine (DG00973):

D04747<JP/US> D08130

Lofepramine (DG00932):

D01285<JP> D08140

Lortalamine:

D04781

Maprotiline (DG00941):

D00818<JP> D02566

Mazindol:

D00367<JP>

Metamfetamine (DG00968):

D02242<JP/US> D08187

Methylphenidate (DG00969):

D01296<JP/US> D04999<US>

Midomafetamine (DG03316):

D11172 D12937

Milnacipran (DG00960):

D01107<JP/US> D08222

Napamezole hydrochloride:

Napitane mesylate:

Nisoxetine:

Nomifensine:

Nortriptyline (DG00935):

D00816<JP/US> D08288

Oxaprotiline hydrochloride:

D05284

Phendimetrazine (DG01537):

D02080<US> D08347 D08348

Phenmetrazine hydrochloride:

D05454

Phentermine (DG00102):

D05458 D05459<US>

Protriptyline (DG00936):

D00484<US> D08447

Pyrovalerone hydrochloride:

D05663

Radafaxine hydrochloride:

D05692

Reboxetine (DG00961):

D02573 D08472

Sibutramine (DG00108):

D02571 D08513

Solriamfetol (DG02989):

D11315 D11328<US>

Talopram hydrochloride:

D05997

Tampramine fumarate:

D02704

Tandamine hydrochloride:

D06004

Tapentadol (DG00826):

D06007 D10199<JP/US>

Tenamfetamine:

D12715

Toludesvenlafaxine (DG03141):

D11940 D11941

Trimipramine (DG00931):

D00394 D02408<JP/US>

Venlafaxine (DG00959):

D00821<JP/US> D08670 D12403<US>

Viloxazine (DG00956):

D02572<US> D08673

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    6530 (SLC6A2)
09150 Organismal Systems
  09156 Nervous system
   04721 Synaptic vesicle cycle
    6530 (SLC6A2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6530 (SLC6A2)
Transporters [BR:hsa02000]
Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6530 (SLC6A2)

SSDB

Motif

Pfam:

SNF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

16:55655988..55706192

AA seq 617 aa
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI

NT seq 1854 nt +upstreamnt +downstreamnt
atgcttctggcgcggatgaacccgcaggtgcagcccgagaacaacggggcggacacgggt
ccagagcagccccttcgggcgcgcaaaactgcggagctgctggtggtgaaggagcgcaac
ggcgtccagtgcctgctggcgccccgcgacggcgacgcgcagccccgggagacctggggc
aagaagatcgacttcctgctgtccgtagtcggcttcgcagtggacctggccaacgtgtgg
cgcttcccctacctctgctacaagaacggcggcggtgccttcttgatcccgtacacactg
ttccttatcatcgcggggatgcccctgttctacatggagctggctctgggacagtacaac
cgggagggggctgccaccgtttggaaaatctgcccattcttcaaaggcgttggctatgct
gtcatcctgatcgccctgtacgttggcttctactacaacgtcatcatcgcctggtcactc
tactacctcttctcctccttcaccctcaacctgccctggaccgactgtggccacacctgg
aacagccccaactgtaccgaccccaagctcctcaatggctccgtgcttggcaaccacacc
aagtactccaagtacaagttcacgccggcagccgagttttatgagcgtggtgtcctgcac
cttcacgagagcagcgggattcatgacatcggcctgccccagtggcagctcttgctctgt
ctgatggtcgtcgtcatcgtcttgtattttagcctctggaaaggggtgaagacatcagga
aaggtggtgtggatcacagccacgctgccttacttcgtgctgttcgtgctcctggtccat
ggcgtcacgctgcccggagcctccaatggcatcaatgcctacctgcacatcgacttctac
cgcttgaaagaggccacggtatggattgatgccgcaactcagatatttttttccttgggg
gctggatttggagtattgattgcatttgccagttacaacaaatttgacaacaactgttac
agggatgccctgctgaccagcagcatcaactgtatcaccagcttcgtctctgggttcgcc
atcttctccatccttggttacatggcccatgaacacaaggtcaacattgaggatgtggcc
acagaaggagctggcctagtgttcatcctgtatccagaggccatttctaccctgtctgga
tctacattctgggctgttgtgtttttcgtcatgctcctggcgctgggccttgacagctca
atgggaggcatggaggctgtcatcacgggcctggcagatgacttccaggtcctgaagcga
caccggaaactcttcacatttggcgtcaccttcagcactttccttctcgccctgttctgc
ataaccaagggtggaatttacgtcttgaccctcctggacacctttgctgcgggcacctcc
atcctttttgctgtcctcatggaagccatcggagtttcctggttttatggagtggacagg
ttcagcaacgacatccagcagatgatggggttcaggccgggtctatactggagactgtgc
tggaagttcgtcagtcctgccttcctcctgttcgtggttgtggtcagcatcatcaacttc
aagccactcacctacgacgactacatcttcccgccctgggccaactgggtggggtggggc
atcgccctgtcctccatggtcctggtgcccatctacgtcatctataagttcctcagcacg
cagggctctctttgggagagactggcctatggcatcacgccagagaacgagcaccacctg
gtggctcagagggacatcagacagttccagttgcaacactggctggccatctga

DBGET integrated database retrieval system