KEGG T01001: 6531

Homo sapiens (human): 6531

Entry

6531              CDS       T01001

Symbol

SLC6A3, DAT, DAT1, PKDYS, PKDYS1

Name

(RefSeq) solute carrier family 6 member 3

K05036

solute carrier family 6 (neurotransmitter transporter, dopamine) member 3

Organism

hsa Homo sapiens (human)

Pathway

hsa04082

Neuroactive ligand signaling

hsa04721

Synaptic vesicle cycle

hsa04728

Dopaminergic synapse

hsa05012

Parkinson disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05030

Cocaine addiction

hsa05031

Amphetamine addiction

hsa05034

Alcoholism

Network

nt06028 Dopamine and serotonin metabolism
nt06544 Neuroactive ligand signaling

Element

N01790

Transport of dopamine into the neuron

Disease

H02676

Infantile-onset parkinsonism-dystonia

Drug target

Amfepramone (DG00104):

D03801<US> D07444

Amfetamine (DG00966):

D02074<US> D07445<US>

Amfonelic acid:

D02897

Amitifadine (DG01386):

D10088 D10089

Amphetamine aspartate monohydrate:

D11622

Armodafinil:

D03215<US>

Benzfetamine (DG01755):

D07514 D07515<US>

Brasofensine maleate:

D03153

Bupropion (DG00957):

D00817<US> D07591 D07938<US>

Centanafadine (DG01858):

D10697 D10698

Cocaine (DG00808):

D00110 D02182<US>

Dasotraline (DG01989):

D10700 D10870

Dexamfetamine (DG00967):

D02078<US> D03740<US>

Dexmethylphenidate (DG00972):

D03721<US> D07806

Dextroamphetamine saccharate:

D11623

Iodine ioflupane (123I):

D10014<JP/US>

Lisdexamfetamine (DG00973):

D04747<JP/US> D08130

Mazindol:

D00367<JP>

Mesocarb:

D12716

Metamfetamine (DG00968):

D02242<JP/US> D08187

Methylphenidate (DG00969):

D01296<JP/US> D04999<US>

Midomafetamine (DG03316):

D11172 D12937

Napamezole hydrochloride:

D05119

Phenmetrazine hydrochloride:

D05454

Phentermine (DG00102):

D05458 D05459<US>

Pyrovalerone hydrochloride:

D05663

Radafaxine hydrochloride:

D05692

Sibutramine (DG00108):

D02571 D08513

Solriamfetol (DG02989):

D11315 D11328<US>

Tenamfetamine:

D12715

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    6531 (SLC6A3)
09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    6531 (SLC6A3)
   04721 Synaptic vesicle cycle
    6531 (SLC6A3)
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    6531 (SLC6A3)
   05022 Pathways of neurodegeneration - multiple diseases
    6531 (SLC6A3)
  09165 Substance dependence
   05030 Cocaine addiction
    6531 (SLC6A3)
   05031 Amphetamine addiction
    6531 (SLC6A3)
   05034 Alcoholism
    6531 (SLC6A3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6531 (SLC6A3)
Transporters [BR:hsa02000]
Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6531 (SLC6A3)

SSDB

Motif

Pfam:

SNF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

5:complement(1392794..1445440)

AA seq 620 aa
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV

NT seq 1863 nt +upstreamnt +downstreamnt
atgagtaagagcaaatgctccgtgggactcatgtcttccgtggtggccccggctaaggag
cccaatgccgtgggcccgaaggaggtggagctcatccttgtcaaggagcagaacggagtg
cagctcaccagctccaccctcaccaacccgcggcagagccccgtggaggcccaggatcgg
gagacctggggcaagaagatcgactttctcctgtccgtcattggctttgctgtggacctg
gccaacgtctggcggttcccctacctgtgctacaaaaatggtggcggtgccttcctggtc
ccctacctgctcttcatggtcattgctgggatgccacttttctacatggagctggccctc
ggccagttcaacagggaaggggccgctggtgtctggaagatctgccccatactgaaaggt
gtgggcttcacggtcatcctcatctcactgtatgtcggcttcttctacaacgtcatcatc
gcctgggcgctgcactatctcttctcctccttcaccacggagctcccctggatccactgc
aacaactcctggaacagccccaactgctcggatgcccatcctggtgactccagtggagac
agctcgggcctcaacgacacttttgggaccacacctgctgccgagtactttgaacgtggc
gtgctgcacctccaccagagccatggcatcgacgacctggggcctccgcggtggcagctc
acagcctgcctggtgctggtcatcgtgctgctctacttcagcctctggaagggcgtgaag
acctcagggaaggtggtatggatcacagccaccatgccatacgtggtcctcactgccctg
ctcctgcgtggggtcaccctccctggagccatagacggcatcagagcatacctgagcgtt
gacttctaccggctctgcgaggcgtctgtttggattgacgcggccacccaggtgtgcttc
tccctgggcgtggggttcggggtgctgatcgccttctccagctacaacaagttcaccaac
aactgctacagggacgcgattgtcaccacctccatcaactccctgacgagcttctcctcc
ggcttcgtcgtcttctccttcctggggtacatggcacagaagcacagtgtgcccatcggg
gacgtggccaaggacgggccagggctgatcttcatcatctacccggaagccatcgccacg
ctccctctgtcctcagcctgggccgtggtcttcttcatcatgctgctcaccctgggtatc
gacagcgccatgggtggtatggagtcagtgatcaccgggctcatcgatgagttccagctg
ctgcacagacaccgtgagctcttcacgctcttcatcgtcctggcgaccttcctcctgtcc
ctgttctgcgtcaccaacggtggcatctacgtcttcacgctcctggaccattttgcagcc
ggcacgtccatcctctttggagtgctcatcgaagccatcggagtggcctggttctatggt
gttgggcagttcagcgacgacatccagcagatgaccgggcagcggcccagcctgtactgg
cggctgtgctggaagctggtcagcccctgctttctcctgttcgtggtcgtggtcagcatt
gtgaccttcagacccccccactacggagcctacatcttccccgactgggccaacgcgctg
ggctgggtcatcgccacatcctccatggccatggtgcccatctatgcggcctacaagttc
tgcagcctgcctgggtcctttcgagagaaactggcctacgccattgcacccgagaaggac
cgtgagctggtggacagaggggaggtgcgccagttcacgctccgccactggctcaaggtg
tag

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