KEGG   Homo sapiens (human): 6531
Entry
6531              CDS       T01001                                 
Symbol
SLC6A3, DAT, DAT1, PKDYS, PKDYS1
Name
(RefSeq) solute carrier family 6 member 3
  KO
K05036  solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
Network
nt06028  Dopamine and serotonin metabolism
  Element
N01790  Transport of dopamine into the neuron
Disease
H02676  Infantile-onset parkinsonism-dystonia
Drug target
Amfepramone (DG00104): D03801<US> D07444
Amfetamine (DG00966): D02074<US> D07445<US>
Amfonelic acid: D02897
Amitifadine (DG01386): D10088 D10089
Amphetamine aspartate monohydrate: D11622
Armodafinil: D03215<US>
Benzfetamine (DG01755): D07514 D07515<US>
Brasofensine maleate: D03153
Bupropion (DG00957): D00817<US> D07591 D07938<US>
Centanafadine (DG01858): D10697 D10698
Cocaine (DG00808): D00110 D02182<US>
Dasotraline (DG01989): D10700 D10870
Dexamfetamine (DG00967): D02078<US> D03740<US>
Dexmethylphenidate (DG00972): D03721<US> D07806
Dextroamphetamine saccharate: D11623
Iodine ioflupane (123I): D10014<JP/US>
Lisdexamfetamine (DG00973): D04747<JP/US> D08130
Mazindol: D00367<JP>
Mesocarb: D12716
Metamfetamine (DG00968): D02242<JP/US> D08187
Methylphenidate (DG00969): D01296<JP/US> D04999<US>
Midomafetamine (DG03316): D11172 D12937
Napamezole hydrochloride: D05119
Phenmetrazine hydrochloride: D05454
Phentermine (DG00102): D05458 D05459<US>
Pyrovalerone hydrochloride: D05663
Radafaxine hydrochloride: D05692
Sibutramine (DG00108): D02571 D08513
Solriamfetol (DG02989): D11315 D11328<US>
Tenamfetamine: D12715
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    6531 (SLC6A3)
   04721 Synaptic vesicle cycle
    6531 (SLC6A3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    6531 (SLC6A3)
   05022 Pathways of neurodegeneration - multiple diseases
    6531 (SLC6A3)
  09165 Substance dependence
   05030 Cocaine addiction
    6531 (SLC6A3)
   05031 Amphetamine addiction
    6531 (SLC6A3)
   05034 Alcoholism
    6531 (SLC6A3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6531 (SLC6A3)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6531 (SLC6A3)
SSDB
Motif
Pfam: SNF
Other DBs
NCBI-GeneID: 6531
NCBI-ProteinID: NP_001035
OMIM: 126455
HGNC: 11049
Ensembl: ENSG00000142319
Pharos: Q01959(Tclin)
UniProt: Q01959
Position
5:complement(1392794..1445440)
AA seq 620 aa
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
NT seq 1863 nt   +upstreamnt  +downstreamnt
atgagtaagagcaaatgctccgtgggactcatgtcttccgtggtggccccggctaaggag
cccaatgccgtgggcccgaaggaggtggagctcatccttgtcaaggagcagaacggagtg
cagctcaccagctccaccctcaccaacccgcggcagagccccgtggaggcccaggatcgg
gagacctggggcaagaagatcgactttctcctgtccgtcattggctttgctgtggacctg
gccaacgtctggcggttcccctacctgtgctacaaaaatggtggcggtgccttcctggtc
ccctacctgctcttcatggtcattgctgggatgccacttttctacatggagctggccctc
ggccagttcaacagggaaggggccgctggtgtctggaagatctgccccatactgaaaggt
gtgggcttcacggtcatcctcatctcactgtatgtcggcttcttctacaacgtcatcatc
gcctgggcgctgcactatctcttctcctccttcaccacggagctcccctggatccactgc
aacaactcctggaacagccccaactgctcggatgcccatcctggtgactccagtggagac
agctcgggcctcaacgacacttttgggaccacacctgctgccgagtactttgaacgtggc
gtgctgcacctccaccagagccatggcatcgacgacctggggcctccgcggtggcagctc
acagcctgcctggtgctggtcatcgtgctgctctacttcagcctctggaagggcgtgaag
acctcagggaaggtggtatggatcacagccaccatgccatacgtggtcctcactgccctg
ctcctgcgtggggtcaccctccctggagccatagacggcatcagagcatacctgagcgtt
gacttctaccggctctgcgaggcgtctgtttggattgacgcggccacccaggtgtgcttc
tccctgggcgtggggttcggggtgctgatcgccttctccagctacaacaagttcaccaac
aactgctacagggacgcgattgtcaccacctccatcaactccctgacgagcttctcctcc
ggcttcgtcgtcttctccttcctggggtacatggcacagaagcacagtgtgcccatcggg
gacgtggccaaggacgggccagggctgatcttcatcatctacccggaagccatcgccacg
ctccctctgtcctcagcctgggccgtggtcttcttcatcatgctgctcaccctgggtatc
gacagcgccatgggtggtatggagtcagtgatcaccgggctcatcgatgagttccagctg
ctgcacagacaccgtgagctcttcacgctcttcatcgtcctggcgaccttcctcctgtcc
ctgttctgcgtcaccaacggtggcatctacgtcttcacgctcctggaccattttgcagcc
ggcacgtccatcctctttggagtgctcatcgaagccatcggagtggcctggttctatggt
gttgggcagttcagcgacgacatccagcagatgaccgggcagcggcccagcctgtactgg
cggctgtgctggaagctggtcagcccctgctttctcctgttcgtggtcgtggtcagcatt
gtgaccttcagacccccccactacggagcctacatcttccccgactgggccaacgcgctg
ggctgggtcatcgccacatcctccatggccatggtgcccatctatgcggcctacaagttc
tgcagcctgcctgggtcctttcgagagaaactggcctacgccattgcacccgagaaggac
cgtgagctggtggacagaggggaggtgcgccagttcacgctccgccactggctcaaggtg
tag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (7)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Drug (48)   
   KEGG DRUG (48)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
Protein domain (1)   
   Pfam (1)   
All databases (100)   

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