KEGG   Homo sapiens (human): 6543Help
Entry
6543              CDS       T01001                                 

Gene name
SLC8A2, NCX2
Definition
(RefSeq) solute carrier family 8 member A2
  KO
K05849  solute carrier family 8 (sodium/calcium exchanger)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04371  Apelin signaling pathway
hsa04740  Olfactory transduction
hsa04961  Endocrine and other factor-regulated calcium reabsorption
hsa04974  Protein digestion and absorption
hsa04978  Mineral absorption
hsa05410  Hypertrophic cardiomyopathy (HCM)
hsa05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    6543 (SLC8A2)
   04020 Calcium signaling pathway
    6543 (SLC8A2)
   04022 cGMP-PKG signaling pathway
    6543 (SLC8A2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    6543 (SLC8A2)
   04261 Adrenergic signaling in cardiomyocytes
    6543 (SLC8A2)
  09154 Digestive system
   04974 Protein digestion and absorption
    6543 (SLC8A2)
   04978 Mineral absorption
    6543 (SLC8A2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    6543 (SLC8A2)
  09157 Sensory system
   04740 Olfactory transduction
    6543 (SLC8A2)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy (HCM)
    6543 (SLC8A2)
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    6543 (SLC8A2)
   05414 Dilated cardiomyopathy (DCM)
    6543 (SLC8A2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6543 (SLC8A2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    6543 (SLC8A2)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC8: Na+/Ca2+ exchanger
   6543 (SLC8A2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Haparin
  Others
   6543 (SLC8A2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Calx-beta Na_Ca_ex Na_Ca_ex_C
Motif
Other DBs
NCBI-GeneID: 6543
NCBI-ProteinID: NP_055878
OMIM: 601901
HGNC: 11069
Ensembl: ENSG00000118160
Vega: OTTHUMG00000183529
Pharos: Q9UPR5(Tbio)
UniProt: Q9UPR5
Position
19q13.32
AA seq 921 aa AA seqDB search
MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEP
DDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGT
VRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC
IYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV
VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGP
GPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRL
MTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQG
GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV
RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT
VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE
YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLE
VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPS
CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLK
DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY
WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFL
GLWLLYILFASLEAYCHIRGF
NT seq 2766 nt NT seq  +upstreamnt  +downstreamnt
atggctcccctggccttggtgggggtcacactcctcctggcggctcccccatgctccggg
gcagccaccccaaccccctccctgccgcctcccccggccaatgacagcgacaccagcaca
gggggctgccaggggtcctaccgctgccagccgggggtgctgctgcccgtgtgggagccc
gacgacccgtcgctgggtgacaaggcggcacgggcagtggtgtactttgtggccatggtc
tacatgtttctgggagtgtccatcatcgccgaccgtttcatggcggccatcgaggtcatc
acgtcaaaagagaaggagatcaccatcaccaaggccaacggtgagaccagcgtgggcacc
gttcgcatctggaatgagacggtgtccaacctcacgctcatggccctgggctcctccgca
cctgagatcctgctgtcagtcatcgaagtctgcggccacaacttccaggcgggtgagctg
ggcccaggcaccatcgtgggcagcgctgccttcaacatgtttgtggtcatcgccgtgtgc
atctacgtcatcccagccggcgagagccgcaagatcaagcacctgagagtcttctttgtc
actgcctcttggagcatcttcgcctatgtctggctttatctcatccttgctgttttttcc
cccggtgtggtccaggtgtgggaggcgctgctgaccctggtcttcttcccggtgtgcgtg
gtattcgcctggatggccgacaagcggctgctcttctacaagtacgtgtacaagcgctac
cgcaccgacccacgcagcggcatcatcataggcgccgagggcgaccccccgaagagcatc
gagctggacggcacgttcgtgggcgccgaggccccaggtgagctgggcggcctgggcccg
ggccccgccgaggcgcgcgagctggacgccagccgccgcgaggtcatccagatcctcaag
gacctcaagcagaagcacccggacaaggatctggagcagctggtgggcatcgccaactac
tacgcgctgctgcaccagcagaagagccgcgccttctaccgcatccaggccacgcggctg
atgaccggcgccgggaacgtgctgcgcagacacgcggcggacgcctcgcgcagggcggcg
ccggccgagggcgcgggcgaggacgaagacgacggcgccagccgcatcttcttcgagcct
agcctctaccactgcctggagaactgcggctccgtgctgctgtccgtcacgtgccagggc
ggcgagggcaacagcaccttctacgtggactaccgcactgaggacggctctgccaaggcg
ggctccgactacgagtacagcgagggcacgctggtgttcaaaccaggcgagacgcagaag
gagctgcgcatcggcatcatcgacgacgacatcttcgaggaggacgagcatttcttcgtg
cggctgctgaacctgcgcgtgggcgacgcgcagggcatgttcgagccggacggcggcggg
cggcccaaggggcggctggtggcgccgctgctggccaccgtcaccatcctggacgacgac
cacgcaggcatcttctccttccaggaccgcctgctgcacgtgagcgagtgcatgggcacc
gtggacgtgcgcgtcgtgcgcagctcgggcgcgcgcggcaccgtgcgccttccctaccgc
acggtggacggcacggcgcgcggcggcggcgtgcactacgaggacgcgtgcggagagctg
gagtttggcgacgacgagaccatgaaaactcttcaggtgaagatagttgatgacgaggaa
tatgagaaaaaggataatttcttcattgagctgggccagccccagtggcttaagcgaggg
atttcagctctgctactcaatcaaggggatggggacaggaagctaacagccgaggaggag
gaggctcggaggatagcagagatgggcaagccagttcttggggagaactgccggctggag
gtcatcatcgaggagtcatatgattttaagaacacggtggataaactcatcaagaaaacg
aacttggccttggtaattgggacccattcatggagggagcagtttttagaggcaattacg
gtgagcgcaggggacgaggaggaggaggaggacgggtcccgggaggagcggctgccgtcg
tgctttgactacgtgatgcacttcctgacggtgttctggaaggtgctcttcgcctgtgtg
ccccccaccgagtactgccacggctgggcctgctttggtgtctccatcctggtcatcggc
ctgctcaccgccctcattggggacctcgcctcccacttcggctgcaccgttggcctcaag
gactctgtcaatgctgttgtcttcgttgccctgggcacctccatccctgacacgttcgcc
agcaaggtggcggcgctgcaggaccagtgcgccgacgcgtccatcggcaacgtgaccggc
tccaacgcggtgaacgtgttccttggcctgggcgtcgcctggtctgtggccgccgtgtac
tgggcggtgcagggccgccccttcgaggtgcgcactggcacgctggccttctccgtcacg
ctcttcaccgtcttcgccttcgtgggcattgccgtgctgctgtaccggcgccggccgcac
atcggcggcgagctgggcggcccgcgcggacccaagctcgccaccaccgcgctcttcctg
ggcctctggctcctgtacatcctcttcgccagcctggaggcgtactgccacatccggggc
ttctag

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