KEGG   Homo sapiens (human): 6546
Entry
6546              CDS       T01001                                 

Gene name
SLC8A1, NCX1
Definition
(RefSeq) solute carrier family 8 member A1
  KO
K05849  solute carrier family 8 (sodium/calcium exchanger)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04371  Apelin signaling pathway
hsa04740  Olfactory transduction
hsa04961  Endocrine and other factor-regulated calcium reabsorption
hsa04974  Protein digestion and absorption
hsa04978  Mineral absorption
hsa05410  Hypertrophic cardiomyopathy
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    6546 (SLC8A1)
   04020 Calcium signaling pathway
    6546 (SLC8A1)
   04022 cGMP-PKG signaling pathway
    6546 (SLC8A1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    6546 (SLC8A1)
   04261 Adrenergic signaling in cardiomyocytes
    6546 (SLC8A1)
  09154 Digestive system
   04974 Protein digestion and absorption
    6546 (SLC8A1)
   04978 Mineral absorption
    6546 (SLC8A1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    6546 (SLC8A1)
  09157 Sensory system
   04740 Olfactory transduction
    6546 (SLC8A1)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    6546 (SLC8A1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    6546 (SLC8A1)
   05414 Dilated cardiomyopathy
    6546 (SLC8A1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6546 (SLC8A1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    6546 (SLC8A1)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC8: Na+/Ca2+ exchanger
   6546 (SLC8A1)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Others
   6546 (SLC8A1)
SSDB
Motif
Pfam: Calx-beta Na_Ca_ex Na_Ca_ex_C DnaG_DnaB_bind
Other DBs
NCBI-GeneID: 6546
NCBI-ProteinID: NP_066920
OMIM: 182305
HGNC: 11068
Ensembl: ENSG00000183023
Vega: OTTHUMG00000102183
Pharos: P32418(Tbio)
UniProt: P32418
Position
2p22.1
AA seq 973 aa
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE
NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPV
FRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY
EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF
LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF
VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF
KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF
FSSLEAYCHIKGF
NT seq 2922 nt   +upstreamnt  +downstreamnt
atgtacaacatgcggcgattaagtctttcacccaccttttcaatgggatttcatctgtta
gttactgtgagtctcttattttcccatgtggaccatgtaattgctgagacagaaatggaa
ggagaaggaaatgaaactggtgaatgtactggatcatattactgtaagaaaggggtgatt
ttgcccatttgggaaccccaagacccttcttttggggacaaaattgctagagctactgtg
tattttgtggccatggtctacatgtttcttggagtctctatcatagctgatcggttcatg
tcctctatagaagtcatcacatctcaagaaaaagaaataaccataaagaaacccaatgga
gagaccaccaagacaactgtgaggatctggaatgaaacagtttctaacctgaccttgatg
gccctgggatcttctgctcctgagattctcctttcagtaattgaagtgtgtggccataac
ttcactgcaggagacctcggtcctagcaccatcgtgggaagtgctgcattcaatatgttc
atcattattgcactctgtgtttatgtggtgcctgacggagagacaaggaagattaagcat
ttgcgtgtcttctttgtgacagcagcctggagcatctttgcctacacctggctttacatt
attttgtctgtcatatctcctggtgttgtggaggtctgggaaggtttgcttactttcttc
ttctttcccatctgtgttgtgttcgcttgggtagcggataggagacttctgttttacaag
tatgtctacaagaggtatcgagctggcaagcagagggggatgattattgaacatgaagga
gacaggccatcttctaagactgaaattgaaatggacgggaaagtggtcaattctcatgtt
gaaaatttcttagatggtgctctggttctggaggtggatgagagggaccaagatgatgaa
gaagctaggcgagaaatggctaggattctgaaggaacttaagcagaagcatccagataaa
gaaatagagcaattaatagaattagctaactaccaagtcctaagtcagcagcaaaaaagt
agagcattttatcgcattcaagctactcgcctcatgactggagctggcaacattttaaag
aggcatgcagctgaccaagcaaggaaggctgtcagcatgcacgaggtcaacactgaagtg
actgaaaatgaccctgttagtaagatcttctttgaacaagggacatatcagtgtctggag
aactgtggtactgtggcccttaccattatccgcagaggtggtgatttgactaacactgtg
tttgttgacttcagaacagaggatggcacagcaaatgctgggtctgattatgaatttact
gaaggaactgtggtgtttaagcctggtgatacccagaaggaaatcagagtgggtatcata
gatgatgatatctttgaggaggatgaaaatttccttgtgcatctcagcaatgtcaaagta
tcttctgaagcttcagaagatggcatactggaagccaatcatgtttctacacttgcttgc
ctcggatctccctccactgccactgtaactatttttgatgatgaccacgcaggcattttt
acttttgaggaacctgtgactcatgtgagtgagagcattggcatcatggaggtgaaagta
ttgagaacatctggagctcgaggaaatgttatcgttccatataaaaccatcgaagggact
gccagaggtggaggggaggattttgaggacacttgtggagagctcgaattccagaatgat
gaaattgtcaaaacaatatcagtcaaggtaattgatgatgaggagtatgagaaaaacaag
accttcttccttgagattggagagccccgcctggtggagatgagtgagaagaaagccctg
ttattgaatgagcttggtggcttcacaataacaggaaaatacctgtttggccaacctgtc
ttcaggaaggttcatgctagagaacatccgattctctctactgtaatcaccattgcagac
gaatatgatgacaagcagccactgaccagcaaagaggaagaggagaggcgcattgcagaa
atggggcgccccatcctgggagagcacaccaagttggaagtgatcattgaagaatcctat
gaattcaagagtactgtggacaaactcattaagaagacaaacctggcccttgtggttggg
actaacagctggagagaacagttcattgaagctatcactgtcagtgctggggaagatgat
gacgacgatgaatgtggggaagagaagctgccctcctgtttcgattacgtgatgcacttt
ctgactgtgttctggaaggtcctgtttgccttcgtcccccctactgaatactggaatggc
tgggcgtgtttcattgtctccatcctcatgattggcctactgacagctttcattggagac
ctggcttcccactttggctgcaccattggcctgaaagattctgtgactgcagtcgtgttc
gtcgcacttggaacatcagtgccagacacatttgccagcaaagtggcagccacccaggac
cagtatgcagacgcctccataggtaacgtcacgggcagcaacgcggtgaatgtcttcctg
ggaatcggtgtggcctggtccatcgctgccatctaccacgcagccaatggggaacagttc
aaagtgtcccctggcacactagctttctctgtcactctcttcaccatttttgctttcatc
aatgtgggggtgctgctgtatcggcggaggccagaaatcggaggtgagctgggtgggccc
cggactgccaagctcctcacatcctgcctctttgtgctcctatggctcttgtacattttc
ttctcctccctggaggcctactgccacataaaaggcttctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (38)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (36)   
DNA sequence (78)   
   RefSeq(nuc) (36)   
   GenBank (21)   
   EMBL (21)   
Protein domain (4)   
   Pfam (4)   
All databases (155)   

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